Results 11 to 20 of about 5,839 (199)
Metamizole-associated adverse events: a systematic review and meta-analysis. [PDF]
PLoS ONE, 2015 BackgroundMetamizole is used to treat pain in many parts of the world. Information on the safety profile of metamizole is scarce; no conclusive summary of the literature exists.ObjectiveTo determine whether metamizole is clinically safe compared to ...
Thomas Kötter +7 more
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Pharmacological characteristics of metamizole [PDF]
Polish Journal of Veterinary Sciences, 2014 Abstract Metamizole (dipyrone) is a popular analgetic, non-opioid drug, commonly used in human and veterinary medicine. In some cases, this agent is still incorrectly classified as a non-steroidal anti-inflammatory drug (NSAID). Metamizole is a pro-drug, which spontaneously breaks down after oral administration to structurally related pyrazolone ...
A, Jasiecka +2 more
openaire +3 more sources
Metamizole-induced agranulocytosis (MIA): a mini review
Molecular and Cellular Pediatrics, 2023 Metamizole is an analgesic, antipyretic, and spasmolytic drug in Germany only approved for the treatment of severe pain or high fever that does not respond to other measures.
Markos K. Tomidis Chatzimanouil +4 more
doaj +3 more sources
Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group Study [PDF]
Frontiers in Pharmacology, 2021 Aim: The objective was to investigate the effect of metamizole on renal function in healthy, salt-depleted volunteers. In addition, the pharmacokinetics of the four major metamizole metabolites were assessed and correlated with the pharmacodynamic effect
Lea S Blaser +14 more
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Acute Liver Failure in a Patient Treated With Metamizole
Frontiers in Pharmacology, 2019 We report on a patient who developed acute liver failure while being treated with metamizole. After liver transplantation, the patient recovered rapidly. Liver biopsy showed massive necrosis and lobular infiltration of lymphocytes.
Philipp Krisai +6 more
doaj +2 more sources
Metamizole: Current status of the safety and efficacy [PDF]
Hospital Pharmacology, 2018 Metamizole is a nonsteroidal anti-inflammatory drug, with analgesic, antipyretic, spasmolytic, and weak anti-inflammatory properties. The analgesic effect of metamizole seems to be based on the inhibition of cyclooxygenase enzyme activity and stimulation
Miljković Milijana N. +4 more
doaj +2 more sources
Metamizole Utilization and Expenditure During 6-Year Period: Serbia vs. Croatia [PDF]
Frontiers in Public Health, 2018 Background: Metamizole is a medication with analgesic, antipyretic, spasmolytic, and weak anti-inflammatory effects. The aim of our study was to evaluate a six-year trend in the utilization and expenditure of metamizole in comparison to other group of ...
Milijana Miljkovic +6 more
doaj +2 more sources
Chemosensors, 2022 The technology for manufacturing a film membrane of the metamizole-selective electrode containing ion associate metamizole-octadecylammonium ODAH+MT− as an electrode active component (EAC) has been proposed. The main potentiometric characteristics of the
Sarizhat D. Tataeva +6 more
doaj +2 more sources
Acute renal failure and severe thrombocytopenia associated with metamizole
Saudi Journal of Kidney Diseases and Transplantation, 2014 Metamizole or dipyrone is a pyrazolone derivative that belongs to the non-steroidal anti-inflammatory drugs. Its main side-effect is hematological toxicity.
Maria Dolores Redondo-Pachon +5 more
doaj +2 more sources
Clinical safety of metamizole [PDF]
, 2016 Metamizole is an old analgesic agent. Its use is highly controversial due to its capacity to induce agranulocytosis, a rapid and severe fall of neutrophil granulocytes with risk of fatal outcome. Despite of this debate and withdrawal from the market in several countries, the use of metamizole increased in the last ten years in Switzerland as well as in
Blaser, Lea-Sara
openaire +3 more sources