Results 11 to 20 of about 5,434 (205)
Metamizole-induced agranulocytosis (MIA): a mini review
Molecular and Cellular Pediatrics, 2023 Metamizole is an analgesic, antipyretic, and spasmolytic drug in Germany only approved for the treatment of severe pain or high fever that does not respond to other measures.
Markos K. Tomidis Chatzimanouil +4 more
doaj +3 more sources
Pharmacological characteristics of metamizole
Polish Journal of Veterinary Sciences, 2014 Abstract Metamizole (dipyrone) is a popular analgetic, non-opioid drug, commonly used in human and veterinary medicine. In some cases, this agent is still incorrectly classified as a non-steroidal anti-inflammatory drug (NSAID). Metamizole is a pro-drug, which spontaneously breaks down after oral administration to structurally related pyrazolone ...
A, Jasiecka +2 more
openaire +3 more sources
Metamizole: Current status of the safety and efficacy [PDF]
Hospital Pharmacology, 2018 Metamizole is a nonsteroidal anti-inflammatory drug, with analgesic, antipyretic, spasmolytic, and weak anti-inflammatory properties. The analgesic effect of metamizole seems to be based on the inhibition of cyclooxygenase enzyme activity and stimulation
Miljković Milijana N. +4 more
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Chemosensors, 2022 The technology for manufacturing a film membrane of the metamizole-selective electrode containing ion associate metamizole-octadecylammonium ODAH+MT− as an electrode active component (EAC) has been proposed. The main potentiometric characteristics of the
Sarizhat D. Tataeva +6 more
doaj +2 more sources
Metamizole: Indications and risks [PDF]
Deutsches Ärzteblatt internationalMetamizole is the most commonly prescribed analgesic drug in Germany, with 280 million daily doses prescribed per year. It is generally considered safe, yet it is controversial and not approved for use in many countries because of the very rare, but potentially lethal risk of agranulocytosis.This narrative review is based on pertinent publications ...
Cascorbi, Ingolf, Baron, Ralf
openaire +3 more sources
Acute renal failure and severe thrombocytopenia associated with metamizole
Saudi Journal of Kidney Diseases and Transplantation, 2014 Metamizole or dipyrone is a pyrazolone derivative that belongs to the non-steroidal anti-inflammatory drugs. Its main side-effect is hematological toxicity.
Maria Dolores Redondo-Pachon +5 more
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Metamizole-induced agranulocytosis from a German intensive care perspective [PDF]
Frontiers in MedicineBackground/objectivesMetamizole (dipyrone) is a non-opioid analgesic and antipyretic widely used in Germany, with prescriptions having increased more than tenfold since 1997.
Laura Hille +5 more
doaj +2 more sources
Biotechnology & Biotechnological Equipment, 2018 Cancer pain treatment is a big challenge for healthcare providers and patients as well. The wide range of non-steroidal anti-inflammatory drugs (NSAIDs) used as painkillers in cancer patients, requires in-depth characterization of their effect on the ...
Irina Nikolova +6 more
doaj +2 more sources
A systematic review and pharmacovigilance analysis of the risk of agranulocytosis associated with metamizole use [PDF]
Scientific ReportsMetamizole is an analgesic widely used after its introduction but later withdrawn in several countries due to the risk of agranulocytosis. Despite this, it remains frequently used worldwide.
Alessia Zinzi +7 more
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Assessing potential risk factors for metamizole-induced leukopenia
Therapeutic Advances in Drug SafetyBackground: Metamizole is a non-opioid analgesic agent that can rarely cause agranulocytosis, a severe form of leukopenia. Objectives: The aim of this study was to assess previously identified potential risk factors for the development of metamizole ...
Birgit Brüne +8 more
doaj +2 more sources