Antipyretic effect of oral dipyrone (Metamizole) compared to oral ibuprofen in febrile children: a systematic review and meta-analysis [PDF]
BMC PediatricsBackground Dipyrone (Metamizole) is a potent pain reliever and fever reducer with muscle relaxant properties, most commonly used as an analgesic and antipyretic agent.
Maged Alnajar +5 more
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Effects of dipyrone on the digestive tract [PDF]
Brazilian Journal of Medical and Biological Research, 2019 Dipyrone (metamizole), acting through its main metabolites 4-methyl-amino-antipyrine and 4-amino-antipyrine, has established analgesic, antipyretic, and spasmolytic pharmacological effects, which are mediated by poorly known mechanisms.
E.F. Collares, L.E.A. Troncon
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A clinical case and pharmacokinetic analysis of an inadvertent overdose of dipyrone (metamizole) without clinical toxicity: A case report [PDF]
SAGE Open Medical Case ReportsDipyrone (metamizole) is a widely used non-opioid analgesic. Its use is restricted due to the risk of side effects such as liver toxicity. We report the case of a patient who accidentally received an oral dose of 12.5 g (132 mg/kg) dipyrone.
Andreas Wehrfritz +6 more
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Dipyrone use in Brazil: clinical conditions, sociodemographic characteristics, population attitudes and perceptions [PDF]
Cadernos de Saúde PúblicaThis study aims to analyze self-reported dipyrone use among the Brazilian population. We used data from the Brazilian National Survey on Access, Use, and Promotion of Rational Use of Medicines (PNAUM), conducted from September 2013 to February 2014 in ...
Eloá Fátima Ferreira de Medeiros +7 more
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São Paulo Medical JournalCONTEXT AND OBJECTIVE: Dipyrone is a widely used over-the-counter antipyretic in Latin America, and elsewhere among Latin immigrants. Despite limited evidence, physicians often prescribe oral ibuprofen or intramuscular dipyrone as the most effective ...
Judith Prado +4 more
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Dipyrone and acetaminophen: correct dosing by parents?
São Paulo Medical JournalCONTEXT AND OBJECTIVE: Several studies in developed countries have documented that a significant percentage of children are given inappropriate doses of acetaminophen and ibuprofen.
João Guilherme Bezerra Alves +3 more
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Tepid sponging plus dipyrone versus dipyrone alone for reducing body temperature in febrile children
São Paulo Medical JournalCONTEXT AND OBJECTIVE: The role of tepid sponging to promote fever control in children is controversial. We did not find any studies reporting on the effectiveness of tepid sponging in addition to dipyrone.
João Guilherme Bezerra Alves +2 more
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Prevalence and predictors of analgesic use during early pregnancy in a Brazilian population [PDF]
Frontiers in PharmacologyIntroductionAlthough the use of analgesics is generally not recommended during pregnancy, several studies have reported a high prevalence of use among pregnant women.
Marcella Tapias Passoni +12 more
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Brazilian Journal of Medical and Biological Research, 2002 Acute headaches are responsible for a significant percentage of the case load at primary care units and emergency rooms in Brazil. Dipyrone (metamizol) is easily available in these settings, being the most frequently used drug. We conducted a randomized,
M.E. Bigal, C.A. Bordini, J.G. Speciali
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Metamizole-induced agranulocytosis from a German intensive care perspective [PDF]
Frontiers in MedicineBackground/objectivesMetamizole (dipyrone) is a non-opioid analgesic and antipyretic widely used in Germany, with prescriptions having increased more than tenfold since 1997.
Laura Hille +5 more
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