EFFECT OF DIPYRONE ON THE RENAL CLEARANCE AND URINARY EXCRETION OF NORFLOXACIN IN SHEEP [PDF]
The effect of dipyrone on the renal clearance and urinary excretion of norfloxacin was investigated in eight healthy female sheep. In each animal, after a single intramuscular administration of norfloxacin, 5 mg/kg body weight, a wash out period of seven
I. Javed, M. Shahzad, T. Khaliq, F. H. Khan, F. Muhammad, B. Aslam and Z. Iqbal
doaj
. Introduction:. The nonopioid analgesic and antipyretic dipyrone (metamizol) is frequently used worldwide. Dipyrone is a prodrug, and the metabolites 4-N-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA) seem to induce analgesia and antipyresia in ...
Stefan Alexander Schenk +4 more
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The long and winding road of non steroidal antinflammatory drugs and paracetamol in cancer pain management: A critical review [PDF]
The aim of this review was to assess the value of NSAIDs and paracetamol in patients with cancer pain to update a previous review performed ten years ago on this topic.
GIARRATANO, Antonino, Mercadante, S
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Do endogenous opioids and nitric oxide participate in the anticonvulsant action of dipyrone?
It was previously reported that systemic administration of dipyrone inhibited the tonic component of generalized tonic-clonic seizures in both the electroshock and the audiogenic seizure models.
G.M.L. Reis +3 more
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Lack of influence of the COX inhibitors metamizol and diclofenac on platelet GPIIb/IIIa and P-selectin expression [PDF]
Background The effect of non-steroidal anti-inflammatory drugs (NSAIDs) for reduced platelet aggregation and thromboxane A2 synthesis has been well documented. However, the influence on platelet function is not fully explained.
Dirk Scheinichen +34 more
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Investigation of pharmaceutical metabolites in environmental waters by LC-MS/MS [PDF]
Pharmaceuticals, once ingested, are commonly metabolized in the body into more polar and soluble forms. These compounds might not be completely removed in the wastewater treatment plants and consequently being discharged into the aquatic ecosystem.
GRACIA LOR, EMMA +4 more
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Atividade antinociceptiva de Ipomoea imperati (Vahl) Griseb., Convolvulaceae [PDF]
Ipomoea imperati (Vahl) Griseb., Convolvulaceae, is used in folk medicine for the treatment of inflammation, swelling and wounds, as well as to treat pains after childbirth and for stomach problems.
AUR, Carlos R. +6 more
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CONTEXT AND OBJECTIVE: Dipyrone is a widely used over-the-counter antipyretic in Latin America, and elsewhere among Latin immigrants. Despite limited evidence, physicians often prescribe oral ibuprofen or intramuscular dipyrone as the most effective ...
Judith Prado +4 more
doaj +1 more source
Dipyrone use in Brazil: clinical conditions, sociodemographic characteristics, population attitudes and perceptions [PDF]
This study aims to analyze self-reported dipyrone use among the Brazilian population. We used data from the Brazilian National Survey on Access, Use, and Promotion of Rational Use of Medicines (PNAUM), conducted from September 2013 to February 2014 in ...
Eloá Fátima Ferreira de Medeiros +7 more
doaj +2 more sources
Fast determination of 40 drugs in water using large volume direct injection liquid chromatography–tandem mass spectrometry [PDF]
This work describes a rapid analytical method based on direct sample injection of water samples for the simultaneous identification/quantification of 40 emerging compounds, including pharmaceuticals and drugs of abuse.
Aranda Mares, José Luis +6 more
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