Results 21 to 30 of about 3,877 (186)

Impact of Concomitant Metamizole Treatment on the Exposure of Mould-Active Triazoles. [PDF]

Mycoses
ABSTRACT Aim Metamizole is an analgesic drug with moderate cytochrome P450 (CYP) inductive properties. The antifungal triazoles are metabolized by several CYP enzymes, but the interaction with metamizole remains poorly described. We investigated the influence of metamizole on the exposure of voriconazole, isavuconazole, and posaconazole.
Vanneste D, De Booser I, Nadrah K, Somrak M, Gijsen M, Matos A, Kalan K, Morlion B, Rex S, Battelino S, Lagrou K, Maertens J, Spriet I.   +12 more
europepmc   +2 more sources

Tilidine and dipyrone (metamizole) in cold pressor pain: A pooled analysis of efficacy, tolerability, and safety in healthy volunteers

Clinical and Translational Science, 2021
The cold pressor test (CPT) is widely implemented and offers a simple, experimental acute pain model utilizing cold pain. Previous trials have frequently paired the CPT with opioids in order to investigate the mechanisms underlying pharmacological ...
Julian Kleine‐Borgmann, Johannes Wilhelmi, Johannes Kratel, Frederik Baumann, Katharina Schmidt, Matthias Zunhammer, Ulrike Bingel   +6 more
doaj   +1 more source

Excess Mortality in Aspirin and Dipyrone (Metamizole) Co‐Medicated Patients With Cardiovascular Disease: A Nationwide Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Pain is a major issue in our aging society. Dipyrone (metamizole) is one of the most frequently used analgesics. Additionally, it has been shown to impair pharmacodynamic response to aspirin as measured by platelet function tests.
Amin Polzin, Lisa Dannenberg, Carolin Helten, Martin Pöhl, Daniel Metzen, Philipp Mourikis, Christof Dücker, Ursula Marschall, Helmut L’Hoest, Beata Hennig, Saif Zako, Kajetan Trojovsky, Tobias Petzold, Christian Jung, Bodo Levkau, Tobias Zeus, Karsten Schrör, Thomas Hohlfeld, Malte Kelm   +18 more
doaj   +1 more source

Dipyrone has no effects on bone healing of tibial fractures in rats [PDF]

Acta Ortopédica Brasileira, 2014
OBJECTIVE: To evaluate the effect of dipyrone on healing of tibial fractures in rats. METHODS: Fourty-two Wistar rats were used, with mean body weight of 280g.
Julio Cesar Gali, Dennis Sansanovicz, Fernando Carvalho Ventin, Rodrigo Henrique Paes, Francisco Carlos Quevedo, Edie Benedito Caetano   +5 more
doaj   +1 more source

2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties

Pharmaceuticals, 2022
Among the most recent proposals regarding the mechanism of action of dipyrone, the modulation of cannabinoid receptors CB1 and CB2 appears to be a promising hypothesis.
Daniela R. de Oliveira, Rodolfo C. Maia, Patrícia R. de Carvalho França, Patrícia D. Fernandes, Gisele Barbosa, Lídia M. Lima, Carlos A. Manssour Fraga   +6 more
doaj   +1 more source

The Ionic Associate of Metamizole as an Electrode-Active Component of a PVC Plasticized Membrane Electrode

Chemosensors, 2022
The technology for manufacturing a film membrane of the metamizole-selective electrode containing ion associate metamizole-octadecylammonium ODAH+MT− as an electrode active component (EAC) has been proposed. The main potentiometric characteristics of the
Sarizhat D. Tataeva, Kurban E. Magomedov, Ruslan Z. Zeynalov, Naida D. Baygishieva, Viktorya S. Magomedova, Alina A. Rabadanova, Farid F. Orudzhev   +6 more
doaj   +1 more source

Single dose dipyrone for acute postoperative pain.

, 2010
BACKGROUND: Dipyrone (metamizole) is a non-steroidal anti-inflammatory drug used in some countries to treat pain (postoperative, colic, cancer, and migraine); it is banned in others because of an association with life-threatening blood agranulocytosis ...
Henry J McQuay, McQuay, HJ, Sheena Derry, Edwards, J, Moore, RA, R Andrew Moore, Jayne Edwards, Meseguer, F, Derry, Sheena, Clara Faura, Derry, S, Faura, C   +11 more
core   +2 more sources

Active metabolites of dipyrone induce a redox-dependent activation of the ion channels TRPA1 and TRPV1

PAIN Reports, 2019
. Introduction:. The nonopioid analgesic and antipyretic dipyrone (metamizol) is frequently used worldwide. Dipyrone is a prodrug, and the metabolites 4-N-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA) seem to induce analgesia and antipyresia in ...
Stefan Alexander Schenk, Felicia Dick, Christine Herzog, Mirjam Jeanette Eberhardt, Andreas Leffler   +4 more
doaj   +1 more source

EFFECT OF DIPYRONE ON THE RENAL CLEARANCE AND URINARY EXCRETION OF NORFLOXACIN IN SHEEP [PDF]

Pakistan Veterinary Journal, 2005
The effect of dipyrone on the renal clearance and urinary excretion of norfloxacin was investigated in eight healthy female sheep. In each animal, after a single intramuscular administration of norfloxacin, 5 mg/kg body weight, a wash out period of seven
I. Javed, M. Shahzad, T. Khaliq, F. H. Khan, F. Muhammad, B. Aslam and Z. Iqbal
doaj  

Evidence of the effect of dipyrone on the central nervous system as a determinant of delayed gastric emptying observed in rats after its administration

Brazilian Journal of Medical and Biological Research, 2003
Dipyrone administered intravenously (iv) delays gastric emptying (GE) in rats. The objectives of the present study were to assess: 1) the effect of the dose of dipyrone and time after its iv administration on GE in rats, 2) the effect of subdiaphragmatic
E.F. Collares, A.M. Vinagre
doaj   +1 more source