Results 21 to 30 of about 6,507 (223)

Metamizole/dipyrone for the relief of cancer pain: A systematic review and evidence-based recommendations for clinical practice [PDF]

Palliative Medicine, 2017
BACKGROUND Dipyrone (metamizole) is one of the most widely used non-opioid analgesics for the treatment of cancer pain. AIM Because evidence-based recommendations are not yet available, a systematic review was conducted for the German Guideline ...
J. Gaertner, U. Stamer, C. Rémi, R. Voltz, C. Bausewein, R. Sabatowski, S. Wirz, G. Müller-mundt, S. Simon, A. Pralong, F. Nauck, M. Follmann, L. Radbruch, W. Meissner   +13 more
semanticscholar   +2 more sources

Effect of the GABA B agonist baclofen on dipyrone-induced delayed gastric emptying in rats [PDF]

Brazilian Journal of Medical and Biological Research, 2005
Dipyrone administered intravenously (iv) or intracerebroventricularly (icv) delays gastric emptying (GE) in rats. Gamma-aminobutyric acid (GABA) is the most potent inhibitory neurotransmitter of the central nervous system.
E.F. Collares, A.M. Vinagre
doaj   +2 more sources

Maternal Dipyrone Exposure and Risk of Major Congenital Malformations, Adverse Perinatal and Postnatal Outcomes: A Population-Based Cohort Study. [PDF]

Clin Pharmacol Ther
Pain and fever are common in pregnancy. Dipyrone is widely used in Europe, Latin America, and parts of Asia, but is banned in other countries due to concerns about agranulocytosis. Evidence on its safety in pregnancy remains limited and inconsistent. This study aimed to evaluate whether maternal dipyrone use during the first‐ and third‐trimesters is ...
Shitrit IB, Idan D, Hasidim AA, Michael T, Levy A, Pariente G, Lunenfeld E, Daniel S.   +7 more
europepmc   +2 more sources

Influence of Tramadol on the Intravenous Pharmacokinetics of Dipyrone Active Metabolites in Dogs. [PDF]

J Vet Pharmacol Ther
ABSTRACT This study aimed to compare the pharmacokinetic profile of the active dipyrone metabolites 4‐methylaminoantipyrine (MAA) and 4‐aminoantipyrine (AA) administered alone and in combination with tramadol in dogs. Nine mixed‐breed dogs, weighing 15.33 ± 2.25 kg, participated in a two‐treatment crossover design: G1 received intravenous dipyrone (25 ...
Mouta AN, Arcoverde KN, Dos Anjos Honorato R, Fernandes NS, de Oliveira CVA, Mesquita GC, Passos YDB, Araújo-Silva G, de Paula VV.   +8 more
europepmc   +2 more sources

Adverse effects of dipyrone (Metamizole) use during pregnancy on offspring health: a systematic review and meta-analysis. [PDF]

BMC Pregnancy Childbirth
This meta-analysis and systematic review aimed to review the health outcomes of offspring following dipyrone use during pregnancy. A systematic literature search was conducted in MEDLINE, Embase, and the Cochrane Library to identify clinical trials or ...
Lino GM, Ishibashi FS, Conrado GAM, Bresani-Salvi CC, Galvão PVM.   +4 more
europepmc   +2 more sources

Pharmacokinetic Profile of Two Active Dipyrone Metabolites, 4-Methylaminoantipyrine (MAA) and 4-Aminoantipyrine (AA), Following Intravenous Administration in Dogs: A Preliminary Study. [PDF]

Animals (Basel)
Simple Summary Dipyrone is widely used to control pain. However, although the standard dose for routine use is 25 mg·kg−1, no studies addressing the pharmacokinetics of this drug employing ultra-performance liquid chromatography coupled to mass ...
Mouta AN, Arcoverde KN, Fernandes NS, Passos YDB, Oliveira CVA, Honorato RA, Araujo-Silva G, Paula VV.   +7 more
europepmc   +2 more sources

Time course of CYP3A activity during and after metamizole (dipyrone) in healthy volunteers

British Journal of Clinical Pharmacology, 2023
In patients of all ages, metamizole is a frequently used analgesic. Recently, metamizole has been identified as an inducer of, among others, cytochrome P450 (CYP) 3A activity, but the time course of this interaction has not been evaluated.
Mareile H. Breithaupt, Evelyn Krohmer, L. Taylor, Éva Körner, T. Hoppe-Tichy, Juergen Burhenne, K. Foerster, M. Dachtler, Gerald Huber, Rakesh Venkatesh, K. Eggenreich, D. Czock, G. Mikus, A. Blank, W. Haefeli   +14 more
semanticscholar   +1 more source

Effects of phenylbutazone, firocoxib, and dipyrone on the diuretic response to furosemide in horses

Journal of Veterinary Internal Medicine, 2023
Background Treatment with phenylbutazone (nonselective COX inhibitor) decreases the diuretic and natriuretic effects of furosemide by nearly 30% but the effects of COX‐2 specific inhibitors (firocoxib) and atypical NSAIDs (dipyrone) are unknown ...
J. M. White, Aimee C. Colbath, Harold C. Schott   +2 more
semanticscholar   +1 more source

Use of meloxicam with or without dipyrone in non-surgical embryo recovery in hair sheep: effects on animal welfare.

Reproduction in domestic animals = Zuchthygiene, 2023
The aim of this study was to determine the effectiveness of meloxicam with or without dipyrone on the welfare of ewes subjected to non-surgical embryo recovery (NSER). Two studies were carried out using 51 multiparous Santa Inês ewes.
A. C. S. Ribeiro, A. Taira, V. C. Santos, V. Brair, Maria Paula Fassarella Lopes, M. Balaro, J. Souza-Fabjan, J. D. da Fonseca, R. Ungerfeld, F. Brandão   +9 more
semanticscholar   +1 more source

One hundred years of dipyrone (metamizole): the recent evidence on its safety

Peer Review, 2023
Dipyrone is a non-opioid analgesic drug used for fever and many types of pain. Due to the risk of induced agranulocytosis, it was banned in the early 1980s in several countries, but is still widely used in Brazil, Mexico, China and others.
Luciano Hasimoto Malheiro, A. S. Viana, Jéssica Oliveira de Souza Nascimento, Jonathan Santos Apolonio, Ronaldo Teixeira da Silva, K. O. Silva   +5 more
semanticscholar   +1 more source