Results 51 to 60 of about 6,507 (223)

Efeitos antinociceptivos da dipirona e seus principais metabólitos na nocicepção aguda e hiperalgesia mecânica induzidas por endotelina-1 na pata de camundongos [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2014.A dipirona foi introduzida na prática clínica em 1922.
Schroeder, Samilla Driessen
core  

The Role of Cyclooxygenase Enzymes in the Effects of Losartan and Lisinopril on the Contractions of Rat Thoracic Aorta

Eurasian Journal of Medicine, 2019
Objective: It was suggested that prostaglandins which are synthesized by cyclooxygenase (COX) enzymes contribute to the actions of angiotensin-converting enzyme (ACE) inhibition and angiotensin AT1 receptor antagonism and there is an interaction between ...
Fikriye Yasemin Ozatik, Bilgin Kaygisiz, Kevser Erol   +2 more
doaj   +1 more source

Digital workflow to assess healing after acellular dermal matrix exposure in root coverage: A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background This case report describes 18‐month clinical and digital outcomes after bilateral treatment of multiple gingival recessions using coronally advanced flap plus acellular dermal matrix (ADM). Methods A 46‐year‐old woman with multiple maxillary recessions received bilateral surgery.
Edgar Daniel Vargas‐Quiroga, Ana Carolina Duarte Firmino, Débora S. F. Sávio, Rhayssa Tritula Barini, Juliana Jendiroba Faraoni, Mario Taba‐Jr, Bruna S. H. Tonin, Arthur Belém Novaes Junior   +7 more
wiley   +1 more source

Impact of Dipyrone Administration on Postoperative Analgesia and Aspirin Effect in Patients Undergoing Coronary Artery Bypass Grafting: The Prospective Randomized DipASA Study.

Journal of Cardiothoracic and Vascular Anesthesia
OBJECTIVE The aim of the study was to investigate the impact of dipyrone administration on postoperative analgesia and acetylsalicylic acid (ASA) effect in patients undergoing coronary artery bypass grafting (CABG).
Walter Petermichl, Peter-Paul Ellmauer, Anne Benning, Florian Zeman, Christof Schmid, A. Stadlbauer, Susanne Heimerl, T. Seyfried, Sebastian Blecha   +8 more
semanticscholar   +1 more source

CB1 receptor‐dependent desensitisation of TRPV1 channels contributes to the analgesic effect of dipyrone in sensitised primary sensory neurons

British Journal of Pharmacology, 2020
While dipyrone is a widely used analgesic, its mechanism of action is not completely understood. Recently, we have reported that the dipyrone metabolite 4‐aminoantipyrine (4‐AA) reduces PGE2‐induced pain‐related behaviour through cannabinoid CB1 ...
Gilson Gonçalves dos Santos, Ruihui Li, M. P. E. Ng, J. B. P. Lemes, W. Vieira, I. Nagy, C. H. Tambeli, C. Parada   +7 more
semanticscholar   +1 more source

Uterotrophic and in vitro screening for (anti)estrogenic activity of dipyrone.

Toxicology Letters, 2021
Dipyrone is a commonly used analgesic in many countries and there is limited data on its possible endocrine disrupting effects. We performed a screening for in vivo and in vitro anti(estrogenic) activity of dipyrone.
M. Passoni, G. Palu, N. Grechi, Bruna Andreotti da Silva Amaral, C. Gomes, Claudia Rülker, B. van Ravenzwaay, A. Martino-Andrade   +7 more
semanticscholar   +1 more source

“Eco-friendly HPLC method for analysis of dipyrone and hyoscine in different matrices with biomonitoring”

Scientific Reports
A selective, precise, and accurate reversed HPLC method has been developed and validated for simultaneous separation and determination of two veterinary drugs, dipyrone and hyoscine, in their combined dosage form in the presence of their official ...
Reem A. El Kalla, N. S. Ghoniem, H. Zaazaa, A. E. El Gendy, Ghada A. Sedik   +4 more
semanticscholar   +1 more source

Dipyrone is locally hydrolyzed to 4-methylaminoantipyrine and its antihyperalgesic effect depends on CB2 and kappa-opioid receptors activation.

European Journal of Pharmacology, 2020
Dipyrone is an analgesic pro-drug used clinically to control moderate pain with a high analgesic efficacy and low toxicity. Dipyrone is hydrolyzed to 4-methylaminoantipyrine (4-MAA), which is metabolized to 4-aminoantipyrine (4-AA).
Gilson Gonçalves dos Santos, W. Vieira, P. Vendramini, Bianca Bassani da Silva, Silviane Fernandes Magalhães, C. H. Tambeli, C. Parada   +6 more
semanticscholar   +1 more source

Does dipyrone produce anxiolytic-like effects in mice?

, 2019
Purpose: Paracetamol has been shown to exert anxiolytic-like effects mediated by endocannabinoids via cannabinoid CB1 receptors. Dipyrone is an analgesic with similar effects to paracetamol rather than non-steroidal anti-inflammatory drugs.
Karadag, Cetin Hakan, Topuz, Ruhan Deniz, Dokmeci, Dikmen, Ulugol, Ahmet, Gunduz, Ozgur   +4 more
core   +1 more source

Antidepressant-like effects of Dipyrone researched with forced swim test

, 2017
Dipyrone is an analgesic-antipyretic drug with especially COX-3 inhibition on central prostaglandin system, proven effects on opiatergic and cannabinoid systems, cytokine levels, TRP channels and descending serotonergic-noradrenergic pathways.
Kübra Demirkol, KIROĞLU, OLCAY, Aresh Alizadeh Yegani, Yenagi, Aresh Alizadeh, Emine Ekemen, Olcay Kıroğlu, BERKTAŞ, FATİH, Fatih Berktaş, AKSU, FAZİLET, Fazilet Aksu, DEMİRKOL, KÜBRA, EKEMEN, EMİNE, ALİZADE, ARES   +12 more
core   +2 more sources