Results 31 to 40 of about 5,434 (205)

Metamizole is a moderate cytochrome P450 inducer via the constitutive androstane receptor and a weak inhibitor of CYP1A2. [PDF]

, 2021
Metamizole is an analgesic and antipyretic drug used intensively in certain countries. Previous studies have shown that metamizole induces cytochrome (CYP) 2B6 and possibly CYP3A4.
Puchkov, Maxim, Bachmann, Fabio, Maxim Puchkov, Urs Duthaler, Jörg Huwyler, Manuel Haschke, Stephan Krähenbühl, Fabio Bachmann, Meyer Zu Schwabedissen, Henriette E, Henriette E. Meyer zu Schwabedissen, Huwyler, Jörg, Krähenbühl, Stephan, Haschke, Manuel, Duthaler, Urs, Meyer Zu Schwabedissen, Henriette E.   +14 more
core   +1 more source

A case of chronic disseminated candidiasis in metamizole-induced neutropaenia [PDF]

, 2022
Chronic disseminated candidiasis (CDC) is a severe complication of a disseminated yeast infection mainly seen after prolonged chemotherapy-induced neutropaenia in the context of haematological malignancy.
Stefan Zimmerli, Kalubi, Malela, Zimmerli, Stefan, Colin-Benoit, Eugénie, Eugénie Colin-Benoit, Zimmerli, Stephan, Malela Kalubi   +6 more
core   +1 more source

Metamizole as a Rare Cause of Drug-Induced Liver Injury

European Journal of Case Reports in Internal Medicine, 2022
Drug-induced liver injury (DILI) is a heterogenous entity with a wide range of pathogenetic mechanisms and clinical manifestations. DILI is a diagnosis of exclusion.
Nevena Preveden, Matthias E Liechti, Tobias Oettl, Stefan Erb   +3 more
doaj   +1 more source

Leucopenia associated with metamizole: a case-control study. [PDF]

, 2017
AIMS OF THE STUDY The aim of this study was to identify possible risk factors for the development of leucopenia associated with metamizole use. METHODS A retrospective case-control study was performed.
Stephan Krhenbhl, Haschke, Manuel Martin, Zeller, Andreas, Andreas Holbro, Hofmann, Sarah, Manuel Haschke, Lea Blaser, Blaser, Lea, Alexandra Rtz Bravo, Rätz Bravo, Alexandra, Holbro, Andreas, Hala Hassna, Anne Taegtmeyer, Krähenbühl, Stephan, Andreas Zeller, Hassna, Hala, Taegtmeyer, Anne, Haschke, Manuel, Sarah Hofmann   +18 more
core   +1 more source

Postoperative analgesia and side effects of oral or injectable metamizole (dipyrone) in dogs and cats

Veterinary Evidence, 2023
PICO Question In dogs and cats after surgery, does the peri-operative administration of injectable or oral metamizole (dipyrone) as opposed to no intervention result in lower postoperative pain scores or higher incidence of side effects?   Clinical
Jakub Stadnicki, Mathieu Raillard
doaj   +1 more source

Comparison of metamizole and paracetamol effects on colonic anastomosis and fibroblast activities in Wistar rats

BMC Pharmacology and Toxicology, 2020
Background Leakage following colorectal anastomosis surgery causes various complications associated with high morbidity and mortality, especially in pediatric patients.
Eko Purnomo, Dwi Aris Agung Nugrahaningsih, Nunik Agustriani, Gunadi   +3 more
doaj   +1 more source

Medication Safety in Intravenous Therapy: A Compatibility Study of Clonidine with Drugs Frequently Used in Intensive Care

Pharmaceutics, 2020
The intravenous pharmacotherapy of critically ill patients is extremely challenging due to the high number of drugs administered. We therefore evaluated the physicochemical compatibility of combinations of clonidine with drugs frequently used in an ...
Anna Katharina Koller, Sabine Krebs, Frank Dörje   +2 more
doaj   +1 more source

Liver Injury Associated with Metamizole Exposure: Features of an Underestimated Adverse Event [PDF]

, 2021
INTRODUCTION AND OBJECTIVE The potential of metamizole to cause drug-induced liver injury (DILI) has received increasing attention. We investigated the distinguishing features of a case series comprising 32 patients with suspected metamizole-induced DILI.
Benesic, Andreas, Neumann, Jens, Gerbes, Alexander L., Weber, Sabine   +3 more
core   +1 more source

Effects of metamizole, MAA, and paracetamol on proliferation, apoptosis, and necrosis in the pancreatic cancer cell lines PaTu 8988 t and Panc-1

BMC Pharmacology and Toxicology, 2017
Background Adenocarcinoma of the pancreas is one of the most aggressive cancer diseases affecting the human body. Recent research has shown the importance of the perioperative phase in disease progression.
Manuela Malsy, Bernhard Graf, Anika Bundscherer   +2 more
doaj   +1 more source

Regulation of cyclooxygenase activity by metamizol [PDF]

European Journal of Pharmacology, 1999
The ability of metamizol to inhibit cyclooxygenase-1 and cyclooxygenase-2 activities has been evaluated using different cyclooxygenase sources. Metamizol inhibited purified cyclooxygenase-1 and cyclooxygenase-2 with an IC50 of about 150 microg/ml. A similar IC50 value for cyclooxygenase-2 was obtained in lipopolysaccharide-activated broken murine ...
Campos, Carmen, Gregorio, Rosa de, García Nieto, Raquel, Gago Badenas, Federico, Ortiz Betés, Pablo, Alemany, Susana   +5 more
openaire   +3 more sources