Results 41 to 50 of about 5,839 (199)

Medication Safety in Intravenous Therapy: A Compatibility Study of Clonidine with Drugs Frequently Used in Intensive Care

Pharmaceutics, 2020
The intravenous pharmacotherapy of critically ill patients is extremely challenging due to the high number of drugs administered. We therefore evaluated the physicochemical compatibility of combinations of clonidine with drugs frequently used in an ...
Anna Katharina Koller, Sabine Krebs, Frank Dörje   +2 more
doaj   +1 more source

Ventral posteromedial nucleus of the thalamus as a neuroanatomical target for the anticephalalgic action of valproic acid and metamizole

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2022
Introduction. Valproic acid and metamizole are widely used in the treatment of primary headaches. However, despite the drugs’ proven clinical efficacy, the neurophysiological mechanisms underlying their therapeutic action are poorly understood.
A. Yu. Sokolov, O. A. Lyubashina
doaj   +1 more source

Adecuación de la seguridad del metamizol y agranulocitosis

Atención Primaria, 2021
Resumen: Objetivo: Analizar si la nota informativa de la Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), de 30 de octubre del 2018, sobre agranulocitosis y metamizol contiene la información precisa y necesaria para proteger a los ...
Cristina Garcia del Campo, Miguel Murcia Soler, Inocencia Martinez-Mir, Vicente Palop Larrea   +3 more
doaj   +1 more source

Significant neutropenia induced by metamizole dependent neutrophil antibodies: Metamizole and neutropenia

Blood Transfusion, 2023
PREVIEW Dear Sir, Neutrophils play an important role for the elimination of pathogens during infections. Neutropenia results either from enhanced peripheral neutrophil destruction or decreased neutrophil production. Based on severity, neutropenia is divided in three categories: mild, absolute neutrophil count (ANC)
Curtis, Brian R, Jehle, Stefanie, Bein, Gregor, Bayat, Behnaz, Sachs, Ulrich J   +4 more
openaire   +1 more source

Effects of metamizole, MAA, and paracetamol on proliferation, apoptosis, and necrosis in the pancreatic cancer cell lines PaTu 8988 t and Panc-1

BMC Pharmacology and Toxicology, 2017
Background Adenocarcinoma of the pancreas is one of the most aggressive cancer diseases affecting the human body. Recent research has shown the importance of the perioperative phase in disease progression.
Manuela Malsy, Bernhard Graf, Anika Bundscherer   +2 more
doaj   +1 more source

Liver Injury Associated with Metamizole Exposure: Features of an Underestimated Adverse Event [PDF]

, 2021
INTRODUCTION AND OBJECTIVE The potential of metamizole to cause drug-induced liver injury (DILI) has received increasing attention. We investigated the distinguishing features of a case series comprising 32 patients with suspected metamizole-induced DILI.
Benesic, Andreas, Neumann, Jens, Gerbes, Alexander L., Weber, Sabine   +3 more
core   +1 more source

Regulation of cyclooxygenase activity by metamizol [PDF]

European Journal of Pharmacology, 1999
The ability of metamizol to inhibit cyclooxygenase-1 and cyclooxygenase-2 activities has been evaluated using different cyclooxygenase sources. Metamizol inhibited purified cyclooxygenase-1 and cyclooxygenase-2 with an IC50 of about 150 microg/ml. A similar IC50 value for cyclooxygenase-2 was obtained in lipopolysaccharide-activated broken murine ...
Campos, Carmen, Gregorio, Rosa de, García Nieto, Raquel, Gago Badenas, Federico, Ortiz Betés, Pablo, Alemany, Susana   +5 more
openaire   +3 more sources

Metamizole (dipyrone) for multimodal analgesia in postoperative pain in adults

Palliative Medicine in Practice
BACKGROUND: Metamizole (dipyrone) is a non-opioid analgesic used in perioperative analgesia in some countries. The drug has analgesic, antipyretic, and spasmolytic effects. The complex mechanism has not been fully explained yet. Presumably, the analgesic
Anna Dizner-Gołąb, Dariusz Kosson, Barbara Lisowska   +2 more
doaj   +1 more source

IgE-Mediated Reaction to Metamizole: Evaluation of a Patient with Severe Anaphylaxis

Eurasian Journal of Medicine, 2019
Metamizole, a non-steroidal anti-inflammatory drug with weak anti-inflammatory and spasmolytic effects, is used as an analgesic and antipyretic agent. Many adverse reactions to metamizole, such as early or late-onset systemic reactions and bone marrow ...
Sevket Arslan, Ramazan Ucar, Ahmet Zafer Caliskaner   +2 more
doaj   +1 more source

Cancer co‐medication quality in older patients with polypharmacy: A large randomized trial testing a medication review versus usual care

Journal of Internal Medicine, EarlyView.
Abstract Background Evidence from randomized controlled trials (RCTs) testing medication reviews in geriatric oncology is sparse. Methods We conducted a single‐blinded RCT in ten rehabilitation clinics across Germany. Patients with common cancers, aged ≥ 65 years, and polypharmacy (regularly ≥ five drugs) were randomly allocated in equal proportions to
Miriam Degen, Annette Kopp‐Schneider, Tomislav Vlaski, Sigrid Carlsson, Peter Hallermann, Ludmilla Jewlanowa, Jana Barinoff, Valentin Goede, Christian Lüders, Thomas Kiefer‐Trendelenburg, Diana Lüftner, Jasmin Doll, Jürgen Wagner, Birgit Leibbrand, Hermann Brenner, Ben Schöttker   +15 more
wiley   +1 more source