Results 21 to 30 of about 5,839 (199)

Metamizole (dipyrone) – cytotoxic and antiproliferative effects on HeLa, HT-29 and MCF-7 cancer cell lines

Biotechnology & Biotechnological Equipment, 2018
Cancer pain treatment is a big challenge for healthcare providers and patients as well. The wide range of non-steroidal anti-inflammatory drugs (NSAIDs) used as painkillers in cancer patients, requires in-depth characterization of their effect on the ...
Irina Nikolova, Lyubomir Marinov, Ani Georgieva, Reneta Toshkova, Martin Malchev, Yulian Voynikov, Ivanka Kostadinova   +6 more
doaj   +2 more sources

Use of metamizole and other non-opioid analgesics in Switzerland between 2014 and 2019: an observational study using a large health insurance claims database [PDF]

Swiss Medical Weekly
OBJECTIVE: To investigate claims patterns for metamizole and other non-opioid analgesics in Switzerland. To characterise users of these non-opioid analgesics regarding sex, age, comedications and canton of residence.
Stephan Gut, Marlene Rauch, Manuel Haschke, Carola A. Huber, Jan Gaertner, Nadine Schur, Christoph R. Meier, Julia Spoendlin   +7 more
doaj   +3 more sources

SCORTEN in Contrast: Two Cases of SJS/TEN Overlap With Divergent Outcomes Highlighting the Role of Renal Dysfunction. [PDF]

Clin Case Rep
ABSTRACT Stevens‐Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) overlap is a rare, life‐threatening mucocutaneous reaction typically induced by medications. Reports from Central America remain scarce. We present two contrasting cases of SJS/TEN overlap from Nicaragua.
Alfaro M, Blandón V, Borge M.
europepmc   +2 more sources

Metamizole: Indications and Risks. [PDF]

Dtsch Arztebl Int
Metamizole is the most commonly prescribed analgesic drug in Germany, with 280 million daily doses prescribed per year. It is generally considered safe, yet it is controversial and not approved for use in many countries because of the very rare, but potentially lethal risk of agranulocytosis.This narrative review is based on pertinent publications ...
Cascorbi I, Baron R.
europepmc   +3 more sources

Adherence of NSAID Administration in Patients with Mild and Moderate Traumatic Brain Injury in Dr. Soetomo General Hospital, Surabaya

Juxta: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga, 2021
Introduction: Traumatic brain injury (TBI) has a concerning incidence rate. One of the therapies for patients with TBI is non-steroidal anti-inflammatory drugs (NSAID) administration as an analgesic with proper adherence to achieve optimal therapy ...
Finna Permata Putri, Agus Turchan, Nurmawati Fatimah, Muhtarum Yusuf   +3 more
doaj   +1 more source

Development of Fourier transform infrared spectrophotometric method for identification and determination of marketed metamizole tablet preparation

Jurnal Natural, 2021
Metamizole is a nonsteroidal antiinflammatory drug (NSAID) that functions as an analgesic, antipyretic, and antiinflammatory. Examination of active substance contents is a requirement that must be met to ensure the quality of drug preparations.
NERDY NERDY, EFFENDY DE LUX PUTRA, NILSYA FEBRIKA ZEBUA, CHRISTICA ILSANNA SURBAKTI, JIHAN SAFIRA   +4 more
doaj   +1 more source

Metamizole is a moderate cytochrome P450 inducer via the constitutive androstane receptor and a weak inhibitor of CYP1A2. [PDF]

, 2021
Metamizole is an analgesic and antipyretic drug used intensively in certain countries. Previous studies have shown that metamizole induces cytochrome (CYP) 2B6 and possibly CYP3A4.
Puchkov, Maxim, Bachmann, Fabio, Maxim Puchkov, Urs Duthaler, Jörg Huwyler, Manuel Haschke, Stephan Krähenbühl, Fabio Bachmann, Meyer Zu Schwabedissen, Henriette E, Henriette E. Meyer zu Schwabedissen, Huwyler, Jörg, Krähenbühl, Stephan, Haschke, Manuel, Duthaler, Urs, Meyer Zu Schwabedissen, Henriette E.   +14 more
core   +2 more sources

Maternal Dipyrone Exposure and Risk of Major Congenital Malformations, Adverse Perinatal and Postnatal Outcomes: A Population-Based Cohort Study. [PDF]

Clin Pharmacol Ther
Pain and fever are common in pregnancy. Dipyrone is widely used in Europe, Latin America, and parts of Asia, but is banned in other countries due to concerns about agranulocytosis. Evidence on its safety in pregnancy remains limited and inconsistent. This study aimed to evaluate whether maternal dipyrone use during the first‐ and third‐trimesters is ...
Shitrit IB, Idan D, Hasidim AA, Michael T, Levy A, Pariente G, Lunenfeld E, Daniel S.   +7 more
europepmc   +2 more sources

Case series: Heinz body formation in 13 multimorbid dogs following metamizole administration

Frontiers in Veterinary Science, 2023
BackgroundHeinz Body (HB) anemia is a result of oxidative damage and is an uncommon condition in dogs relative to cats. In this retrospective case series, clinical features, laboratory values, concurrent diseases, and outcomes of 13 multimorbid dogs that
Vera Geisen, Katrin Hartmann, René Dörfelt   +2 more
doaj   +1 more source

A case of chronic disseminated candidiasis in metamizole-induced neutropaenia [PDF]

, 2022
Chronic disseminated candidiasis (CDC) is a severe complication of a disseminated yeast infection mainly seen after prolonged chemotherapy-induced neutropaenia in the context of haematological malignancy.
Stefan Zimmerli, Kalubi, Malela, Zimmerli, Stefan, Colin-Benoit, Eugénie, Eugénie Colin-Benoit, Zimmerli, Stephan, Malela Kalubi   +6 more
core   +2 more sources