Use of metamizole and other non-opioid analgesics in Switzerland between 2014 and 2019: an observational study using a large health insurance claims database [PDF]
Swiss Medical WeeklyOBJECTIVE: To investigate claims patterns for metamizole and other non-opioid analgesics in Switzerland. To characterise users of these non-opioid analgesics regarding sex, age, comedications and canton of residence.
Stephan Gut +7 more
doaj +2 more sources
Metamizole induces voriconazole metabolism and results in subtherapeutic voriconazole concentrations [PDF]
Br J Clin PharmacolAIMS: Voriconazole is extensively metabolized via cytochrome P450 (CYP) enzymes, predominantly CYP2C19 and CYP3A4. Drugs influencing the activity or expression of CYP enzymes can cause clinically relevant changes in the metabolism and voriconazole ...
Baan, Simone D +3 more
core +2 more sources
Agranulocytosis induced by metamizole and its management with granulocyte growth factor [PDF]
Vojnosanitetski Pregled, 2005 Drug-induced agranulocytosis was defined as a severe selective neutropenia caused by an unexpected drug reaction. Metamizole was the most common nonopioid analgesic drug associated with agranulocytosis.
Čeleketić Dušica +2 more
doaj +2 more sources
The effect of scheduled metamizole on opioid consumption after cardiac surgery [PDF]
Frontiers in PharmacologyThis retrospective study evaluates the impact of implementing a standardized scheduled metamizole dosing protocol within a multimodal analgesia approach after cardiac surgery.
Chen Seidenberg +7 more
doaj +2 more sources
Animals, 2020 Pain management during in vivo experiments is an animal welfare concern and is in many countries also legally required. In this study, we evaluated C57Bl/6J mice when 3 g/L metamizole or 1 g/L tramadol was provided via drinking water, before and during ...
Guanglin Tang +4 more
doaj +2 more sources
Metamizole does not affect fracture healing in a murine ischemia model [PDF]
Frontiers in PhysiologyMetamizole is a commonly used analgesic drug in clinical fracture management, which does not affect the healing process under physiological conditions.
Christian Schönbeck +13 more
doaj +2 more sources
Risk Factors for Intolerable Postoperative Pain After Vitreoretinal Surgery Under AoA-Guided General Anesthesia with Intravenous COX-3 Inhibitors: A Post Hoc Analysis [PDF]
PharmaceuticalsBackground/Objectives: Intolerable postoperative pain perception (IPPP) may occur in patients undergoing vitreoretinal surgery (VRS), while general anesthesia (GA) is often preferred over regional techniques due to multiple contraindications ...
Michał J. Stasiowski +3 more
doaj +2 more sources
Clinical safety of metamizole [PDF]
, 2016 Metamizole is an old analgesic agent. Its use is highly controversial due to its capacity to induce agranulocytosis, a rapid and severe fall of neutrophil granulocytes with risk of fatal outcome. Despite of this debate and withdrawal from the market in several countries, the use of metamizole increased in the last ten years in Switzerland as well as in
Blaser, Lea-Sara
openaire +3 more sources
Does Metamizole Cause Less Acute Kidney Injury than Non-Steroidal Anti-Inflammatory Drugs When Combined with Diuretics and Antihypertensives? [PDF]
ToxicsThe concurrent use of (a) diuretics, (b) renin–angiotensin–aldosterone system inhibitors (RAASIs), and (c) non-steroidal anti-inflammatory drugs (NSAIDs) or metamizole, known as the triple whammy (TW) combination, increases the risk of acute kidney ...
Dulce Maria Calvo +6 more
doaj +2 more sources
Interference of metamizole in the measurement of serum creatinine concentration
Advances in Laboratory MedicineThere is little literature on the interference of metamizole in measurement creatinine concentration by the enzymatic method. Some studies have postulated that the dipyrone molecule is responsible for interfering in the last reaction of the enzymatic ...
Castro-Castro María-José +3 more
doaj +2 more sources