Results 71 to 80 of about 40,631 (231)

Amphiregulin-Deficient Mice Develop Spasmolytic Polypeptide Expressing Metaplasia and Intestinal Metaplasia [PDF]

Gastroenterology, 2009
The loss of parietal cells from the fundic mucosa leads to the emergence of metaplastic lineages associated with an increased susceptibility to neoplastic transformation. Both intestinal metaplasia (IM) and spasmolytic polypeptide (TFF2/SP) expressing metaplasia (SPEM) have been identified in human stomach, but only SPEM is present in most mouse models
Ki Taek, Nam, Hyuk-Joon, Lee, Hoyin, Mok, Judith, Romero-Gallo, James E, Crowe, Richard M, Peek, James R, Goldenring   +6 more
openaire   +3 more sources

Enhancement of immune checkpoint inhibitor efficacy by DHX58+ SELL+ T cells in advanced gastric cancer

VIEW, EarlyView.
We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen, Youdong Liu, Hongda Pan, Tianyi Cai, Mingde Zang, Xiaowen Liu, Ziwen Long, Xin Fan, Jun Lu, Fenglin Liu   +9 more
wiley   +1 more source

Role of transcription factor Cdx2 in the development of gastric intestinal metaplasia

Patologìâ, 2012
The role of intestinal differentiation transcription factor Cdx2 in the development of gastric intestinal metaplasia was established on the basis of its expression in material of gastric mucosa biopsies.
S. V. Vernygorodskiy, L. V. Degtyaryova
doaj   +1 more source

Loss of pancreas upon activated Wnt signaling is concomitant with emergence of gastrointestinal identity [PDF]

, 2016
Organ formation is achieved through the complex interplay between signaling pathways and transcriptional cascades. The canonical Wnt signaling pathway plays multiple roles during embryonic development including patterning, proliferation and ...
Cano, David A., Flores Martínez, Álvaro, Hebrok, Matthias, Herrero Martín, Griselda, Muñoz Bravo, José Luis, Puri, Sapna, Rojas González, Anabel, Taketo, Makoto Mark   +7 more
core   +4 more sources

Endoscopic Classification of Intestinal Metaplasia [PDF]

The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2013
Intestinal metaplasia (IM) is recognized as a precancerous condition for intestinal type gastric cancer. Therefore, endoscopic diagnosis of IM is valuable for patients undergoing surveillance endoscopy. However, there are no standard endoscopic findings that distinguish it from the normal mucosa.
Byoung Wook Bang, Hyung Gil Kim
openaire   +1 more source

Inhibition of PHF1 promotes ferroptosis via IRES‐dependent Snail translation regulation in pancreatic ductal adenocarcinoma

VIEW, EarlyView.
PHF1 is a known epigenetic regulator involved in transcriptional silencing in cancer. In this study, we identified PHF1 as an oncogene that promotes PDAC progression and demonstrated that its inhibition induces ferroptosis. Mechanistically, PHF1 physically interacts with the FBL/NOP56/NOP58 snoRNP complex to enhance the IRES‐dependent translation of ...
Yujiao Xie, Shan Jin, Yao Zhan, Tiantian Du, Yaqi Dong, Peilong Li, Xiaoshi Zhang, Qiuchen Qi, Jie Gao, Chuanxin Wang   +9 more
wiley   +1 more source

Murine Models of Gastric Corpus PreneoplasiaSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Intestinal-type gastric adenocarcinoma evolves in a field of pre-existing metaplasia. Over the past 20 years, a number of murine models have been developed to address aspects of the physiology and pathophysiology of metaplasia induction. Although none of
Christine P. Petersen, Jason C. Mills, James R. Goldenring   +2 more
doaj   +1 more source

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan, Karen Hon, Ruby E. Dawson, Teresa Weng, Jelena Solujic, Yu C. J. Chey, James D. Zuiani, Griffith B. Perkins, P. Toby Coates, Chris Drogemuller, Eddie Sanderlin, Lulu Huang, John Finnie, Stefan Rose‐John, Arash Badiei, Phan Nguyen, Brendan J. Jenkins, Mohamed I. Saad   +17 more
wiley   +1 more source

hTERT, MYC and TP53 deregulation in gastric preneoplastic lesions

BMC Gastroenterology, 2012
Background Gastric cancer is a serious public health problem in Northern Brazil and in the world due to its high incidence and mortality. Despite the severity of the disease, more research is needed to better understand the molecular events involved in ...
Silva Tanielly Cristina, Leal Mariana, Calcagno Danielle, de Souza Carolina Rosal, Khayat André, dos Santos Ney Pereira, Montenegro Raquel, Rabenhorst Silvia Helena, Nascimento Mayara, Assumpção Paulo, de Arruda Cardoso Smith Marília, Burbano Rommel   +11 more
doaj   +1 more source

Eccrine Squamous Syringometaplasia Mimicking Acute Cutaneous GVHD in a Pediatric HSCT Recipient: Case Report and Brief Review of the Indexed Literature

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Eccrine squamous syringometaplasia (ESS) is an uncommon reactive alteration of eccrine ducts, most often reported in oncologic and transplant settings, where it may clinically mimic acute cutaneous graft‐versus‐host disease (GVHD). We describe a 3‐year‐old boy with chronic granulomatous disease who developed a diffuse erythematous eruption 6 ...
Benedetta Galli, Cecilia Catapano, Iacopo Ghini, Mariateresa Rossi, Marina Venturini, Valeria Boccaletti   +5 more
wiley   +1 more source