Synaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapses [PDF]
Neural Plasticity, 2015 The relevance of neuronal and synaptic variability remains unclear. Cellular and synaptic plasticity and neuromodulation are also variable. This could reflect state-dependent effects caused by the variable initial cellular or synaptic properties or ...
David Parker
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Regulation of hippocampal synaptic plasticity thresholds and changes in exploratory and learning behavior in dominant negative NPR-B mutant rats [PDF]
Frontiers in Molecular Neuroscience, 2014 The second messenger cyclic GMP affects synaptic transmission and modulates synaptic plasticity and certain types of learning and memory processes. The impact of the natriuretic peptide receptor B (NPR-B) and its ligand C-type natriuretic peptide (CNP ...
Gleb eBarmashenko +6 more
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Effects of TrkB-related induced metaplasticity within the BLA on anxiety, extinction learning, and plasticity in BLA-modulated brain regions [PDF]
Behavioral and Brain FunctionsBackground Neuronal plasticity within the basolateral amygdala (BLA) is fundamental for fear learning. Metaplasticity, the regulation of plasticity states, has emerged as a key mechanism mediating the subsequent impact of emotional and stressful ...
Joyeeta Dutta Hazra +10 more
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Probabilistic metaplasticity for continual learning with memristors in spiking networks [PDF]
Scientific ReportsEdge devices operating in dynamic environments critically need the ability to continually learn without catastrophic forgetting. The strict resource constraints in these devices pose a major challenge to achieve this, as continual learning entails memory
Fatima Tuz Zohora +3 more
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Systemic pharmacological suppression of neural activity reverses learning impairment in a mouse model of Fragile X syndrome [PDF]
eLifeThe enhancement of associative synaptic plasticity often results in impaired rather than enhanced learning. Previously, we proposed that such learning impairments can result from saturation of the plasticity mechanism (Nguyen-Vu et al., 2017), or, more ...
Amin MD Shakhawat +4 more
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Pathway-specific TNF-mediated metaplasticity in hippocampal area CA1
Scientific Reports, 2022 Long-term potentiation (LTP) is regulated in part by metaplasticity, the activity-dependent alterations in neural state that coordinate the direction, amplitude, and persistence of future synaptic plasticity.
Anurag Singh +3 more
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Frontiers in Synaptic Neuroscience, 2021 The history of neural activity determines the synaptic plasticity mechanisms employed in the brain. Previous studies report a rapid reduction in the strength of excitatory synapses onto layer 2/3 (L2/3) pyramidal neurons of the primary visual cortex (V1)
Varun Chokshi +13 more
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Molecular Brain, 2021 The synaptic tag and capture (STC) hypothesis provides an important theoretical basis for understanding the synaptic basis of associative learning. We recently provided pharmacological evidence that calcium-permeable AMPA receptors (CP-AMPARs) are a ...
Pojeong Park +5 more
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Synaptic plasticity and preliminary-spike-enhanced plasticity in a CMOS-compatible Ta2O5 memristor
Materials & Design, 2020 An artificial synapse that can perform both learning and memory functions was realized using an amorphous Ta2O5 memristor. A Pt/Ta2O5/TiN memristor, with an amorphous Ta2O5 film grown at 100 °C, exhibited reliable bipolar switching properties at the ...
Hyun–Gyu Hwang +6 more
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Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm [PDF]
, 2013 We present a mathematical model which explains and interprets a novel form of short-term potentiation, which was found to be use-, but not time-dependent, in experiments done on Lymnaea neurons.
Luck, Jean-Marc +3 more
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