Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm [PDF]
PLoS ONE 8(10): e78056 (2013), 2013 We present a mathematical model which explains and interprets a novel form of short-term potentiation, which was found to be use-, but not time-dependent, in experiments done on Lymnaea neurons.
Luck, Jean-Marc +3 more
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Effects of TrkB-related induced metaplasticity within the BLA on anxiety, extinction learning, and plasticity in BLA-modulated brain regions [PDF]
Behavioral and Brain FunctionsBackground Neuronal plasticity within the basolateral amygdala (BLA) is fundamental for fear learning. Metaplasticity, the regulation of plasticity states, has emerged as a key mechanism mediating the subsequent impact of emotional and stressful ...
Joyeeta Dutta Hazra +10 more
doaj +2 more sources
Synaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapses [PDF]
Neural Plasticity, 2015 The relevance of neuronal and synaptic variability remains unclear. Cellular and synaptic plasticity and neuromodulation are also variable. This could reflect state-dependent effects caused by the variable initial cellular or synaptic properties or ...
Parker, David
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Multiple forms of metaplasticity at a single hippocampal synapse during late postnatal development [PDF]
Developmental Cognitive Neuroscience, 2015 Metaplasticity refers to adjustment in the requirements for induction of synaptic plasticity based on the prior history of activity. Numerous forms of developmental metaplasticity are observed at Schaffer collateral synapses in the rat hippocampus at the
Dumas, Theodore C., McHail, Daniel G.
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Synaptic metaplasticity with multi-level memristive devices [PDF]
, 2023 Deep learning has made remarkable progress in various tasks, surpassing human performance in some cases. However, one drawback of neural networks is catastrophic forgetting, where a network trained on one task forgets the solution when learning a new one.
Arcamone, J +7 more
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Regulation of hippocampal synaptic plasticity thresholds and changes in exploratory and learning behavior in dominant negative NPR-B mutant rats [PDF]
Frontiers in Molecular Neuroscience, 2014 The second messenger cyclic GMP affects synaptic transmission and modulates synaptic plasticity and certain types of learning and memory processes. The impact of the natriuretic peptide receptor B (NPR-B) and its ligand C-type natriuretic peptide (CNP ...
Bader, Michael +6 more
core +7 more sources
Probabilistic metaplasticity for continual learning with memristors in spiking networks [PDF]
Scientific ReportsEdge devices operating in dynamic environments critically need the ability to continually learn without catastrophic forgetting. The strict resource constraints in these devices pose a major challenge to achieve this, as continual learning entails memory
Fatima Tuz Zohora +3 more
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Systemic pharmacological suppression of neural activity reverses learning impairment in a mouse model of Fragile X syndrome [PDF]
eLifeThe enhancement of associative synaptic plasticity often results in impaired rather than enhanced learning. Previously, we proposed that such learning impairments can result from saturation of the plasticity mechanism (Nguyen-Vu et al., 2017), or, more ...
Amin MD Shakhawat +4 more
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Pathway-specific TNF-mediated metaplasticity in hippocampal area CA1
Scientific Reports, 2022 Long-term potentiation (LTP) is regulated in part by metaplasticity, the activity-dependent alterations in neural state that coordinate the direction, amplitude, and persistence of future synaptic plasticity.
Anurag Singh +3 more
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Synaptic metaplasticity in binarized neural networks [PDF]
Computational and Systems Neuroscience (Cosyne) 2021, 2021 Unlike the brain, artificial neural networks, including state-of-the-art deep neural networks for computer vision, are subject to "catastrophic forgetting": they rapidly forget the previous task when trained on a new one. Neuroscience suggests that biological synapses avoid this issue through the process of synaptic consolidation and metaplasticity ...
arxiv +1 more source