Results 11 to 20 of about 8,597 (225)

Heterosynaptic metaplastic regulation of synaptic efficacy in CA1 pyramidal neurons of rat hippocampus [PDF]

, 2004
International audienceThe induction threshold, and the magnitude and direction of changes in synaptic plasticity may depend on the previous history of neuronal activity.
Buño, Washington, Fernández De Sevilla, David, Fuenzalida, Marco, Le Ray, Didier, Porto, Ana,   +4 more
core   +3 more sources

Naturalistic Spike Trains Drive State-Dependent Homeostatic Plasticity in Superficial Layers of Visual Cortex

Frontiers in Synaptic Neuroscience, 2021
The history of neural activity determines the synaptic plasticity mechanisms employed in the brain. Previous studies report a rapid reduction in the strength of excitatory synapses onto layer 2/3 (L2/3) pyramidal neurons of the primary visual cortex (V1)
Varun Chokshi, Varun Chokshi, Bryce D. Grier, Bryce D. Grier, Andrew Dykman, Crystal L. Lantz, Ernst Niebur, Ernst Niebur, Elizabeth M. Quinlan, Elizabeth M. Quinlan, Hey-Kyoung Lee, Hey-Kyoung Lee, Hey-Kyoung Lee, Hey-Kyoung Lee   +13 more
doaj   +1 more source

Further evidence that CP-AMPARs are critically involved in synaptic tag and capture at hippocampal CA1 synapses

Molecular Brain, 2021
The synaptic tag and capture (STC) hypothesis provides an important theoretical basis for understanding the synaptic basis of associative learning. We recently provided pharmacological evidence that calcium-permeable AMPA receptors (CP-AMPARs) are a ...
Pojeong Park, Heather Kang, John Georgiou, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge   +5 more
doaj   +1 more source

Cortical M1 plasticity and metaplasticity in patients with multiple sclerosis [PDF]

, 2020
Background: Previous studies on patients with Multiple Sclerosis (MS) have reported contrasting findings on cortical plasticity of the primary motor cortex and no study has yet evaluated the regulatory mechanisms of cortical plasticity (i.e ...
Baione, V., Belvisi, D., Berardelli, A., Cetta, I., Conte, A., Cortese, A., Millefiorini, E., Tartaglia, M.   +7 more
core   +1 more source

A Systematic Review of the Safety and Tolerability of Theta Burst Stimulation in Children and Adolescents

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Theta burst stimulation (TBS) is often used in clinical practice and research protocols for adults with neuropsychiatric disorders. There are substantial knowledge gaps related to the application of TBS in children and adolescents.
Rana Elmaghraby, Qi Sun, Can Ozger, Julia Shekunov, Magdalena Romanowicz, Paul E. Croarkin   +5 more
wiley   +1 more source

Neurogranin Regulates Metaplasticity

Frontiers in Molecular Neuroscience, 2020
Long-term potentiation (LTP) and long-term depression (LTD) are two major forms of synaptic plasticity that are widely accepted as cellular mechanisms involved in learning and memory.
Ling Zhong, Nashaat Z. Gerges
doaj   +1 more source

Train duration and inter-train interval determine the direction and intensity of high-frequency rTMS after-effects

Frontiers in Neuroscience, 2023
Background and objectiveIt has been proved that repetitive transcranial magnetic stimulation (rTMS) triggers the modulation of homeostatic metaplasticity, which causes the effect of rTMS to disappear or even reverse, and a certain length of interval ...
Jingna Jin, Xin Wang, He Wang, Ying Li, Zhipeng Liu, Tao Yin, Tao Yin   +6 more
doaj   +1 more source

Morphological Responses of Excitatory Prelimbic and Orbitofrontal Cortical Neurons to Excess Corticosterone in Adolescence and Acute Stress in Adulthood

Frontiers in Neuroanatomy, 2020
Considerable evidence indicates that chronic stress and excess glucocorticoids induce neuronal remodeling in prefrontal cortical (PFC) regions. Adolescence is also characterized by a structural reorganization of PFC neurons, yet interactions between ...
Elizabeth T. Barfield, Michelle K. Sequeira, Michelle K. Sequeira, Ryan G. Parsons, Shannon L. Gourley, Shannon L. Gourley   +5 more
doaj   +1 more source

Statistical mechanics of continual learning: variational principle and mean-field potential [PDF]

Phys. Rev. E 108, 014309 (2023), 2022
An obstacle to artificial general intelligence is set by continual learning of multiple tasks of different nature. Recently, various heuristic tricks, both from machine learning and from neuroscience angles, were proposed, but they lack a unified theory ground.
arxiv   +1 more source

Enhanced polychronisation in a spiking network with metaplasticity

Frontiers in Computational Neuroscience, 2015
Computational models of metaplasticity have usually focused on the modeling of single synapses (Shouval et al., 2002). In this paper we study the effect of metaplasticity on network behavior.
Mira eGuise, Alistair eKnott, Lubica eBenuskova   +2 more
doaj   +1 more source