Results 51 to 60 of about 15,121 (239)

Dissecting the Spatial and Single‐Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer

Advanced Science, EarlyView.
A single‐cell and spatial transcriptional atlas reveals the architecture of human gastric cancer stem cell (CSC) niche and the developmental trajectory of CSCs. These CSCs interact with immunosuppressive immune cells thereby constructing immune‐suppressive niche, and inflammatory cancer‐associated fibroblast (iCAFs) to enhance stemness through ...
Guangyu Zhang, Xin Zhang, Wenting Pan, Xizhao Chen, Lingfei Wan, Chunjie Liu, Yuting Yong, Yue Zhao, Shuli Sang, Lihua Zhang, Sheng Yao, Yushu Guo, Mingmei Wang, Xinhui Wang, Guangdun Peng, Xinlong Yan, Yanchun Wang, Min Zhang   +17 more
wiley   +1 more source

Regulation of hippocampal synaptic plasticity thresholds and changes in exploratory and learning behavior in dominant negative NPR-B mutant rats

Frontiers in Molecular Neuroscience, 2014
The second messenger cyclic GMP affects synaptic transmission and modulates synaptic plasticity and certain types of learning and memory processes. The impact of the natriuretic peptide receptor B (NPR-B) and its ligand C-type natriuretic peptide (CNP ...
Gleb eBarmashenko, Jens eButtgereit, Cemil eÖzcelik, Neil eHerring, Michael eBader, Denise eManahan-Vaughan, Karl Heinz eBraunewell   +6 more
doaj   +1 more source

Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity

Neural Plasticity, 2016
Alzheimer’s disease (AD) is an irreversible brain disorder characterized by progressive cognitive decline and neurodegeneration of brain regions that are crucial for learning and memory.
Sung-Soo Jang, Hee Jung Chung
doaj   +1 more source

Synaptic lability after experience-dependent plasticity is not mediated by calcium-permeable AMPARs

Frontiers in Molecular Neuroscience, 2012
Activity- or experience-dependent plasticity has been associated with the trafficking of calcium-permeable AMPARs (CP-AMPARs) in a number of experimental systems.
Jing A Wen, Alison L Barth
doaj   +1 more source

Homosynaptic plasticity induction causes heterosynaptic changes at the unstimulated neighbors in an induction pattern and location-specific manner

Frontiers in Cellular Neuroscience, 2023
Dendritic spines are highly dynamic structures whose structural and functional fluctuations depend on multiple factors. Changes in synaptic strength are not limited to synapses directly involved in specific activity patterns.
Ali Özgür Argunsah, Ali Özgür Argunsah, Inbal Israely   +2 more
doaj   +1 more source

Investigating the role of SARM1 in central nervous system

Ibrain, EarlyView.
Sterile‐α and Toll/interleukin 1 receptor (TIR) motif‐containing protein 1 (SARM1) is a pivotal molecule that has garnered extensive attention in neuroscience. As an intracellular molecule, SARM1 possesses various crucial biological functions in the nervous system.
Junjie Wang, Yuhang Shi, Jinglei Tian, Liming Tang, Fang Cao   +4 more
wiley   +1 more source

Extreme Low Frequency Electromagnetic Field Stimulation Induces Metaplastic-Like Effects on LTP/ LTD

IEEE Access, 2019
In modern societies, people are more likely to be exposed to technological devices that emit extreme low frequency (ELF, <; 300 Hz)-electromagnetic fields (EMFs).
Yu Zheng, Chunxiao Tian, Lei Dong, Xiaoxu Ma, Yang Gao, Chan Xiong, Kanghui Zhang, Chengshuang Li   +7 more
doaj   +1 more source

Full imitation of synaptic metaplasticity based on memristor devices.

Nanoscale, 2018
Neuromorphic engineering is a promising technology for developing new computing systems owing to the low-power operation and the massive parallelism similarity to the human brain.
Quantan Wu, Hong Wang, Q. Luo, W. Banerjee, Jingchen Cao, Xumeng Zhang, Facai Wu, Qi Liu, Ling Li, Ming Liu   +9 more
semanticscholar   +1 more source

Human sporadic breast carcinoma histotypes driven by the Human Betaretrovirus homologous to Mouse Mammary Tumor Virus

International Journal of Cancer, EarlyView.
What's New? While estrogens, obesity, and alcohol are recognized risk factors for breast cancer, a viral hypothesis has been suggested based on the murine model of Mouse Mammary Tumor Virus (MMTV)‐induced mammary tumors. This study analyzed sequences of the human homolog of MMTV across human breast carcinoma histotypes, detecting the virus in all types
Prospero Civita, Chiara Maria Mazzanti, Francesca Lessi, Caterina Marchiò, Cristian Scatena, Michele Menicagli, Matteo Ghilli, Manuela Roncella, Antonio Giuseppe Naccarato, Anna Sapino, Jacob Hochman, Mauro Pistello, Generoso Bevilacqua   +12 more
wiley   +1 more source

Metaplasticity in Multistate Memristor Synaptic Networks [PDF]

arXiv, 2020
Recent studies have shown that metaplastic synapses can retain information longer than simple binary synapses and are beneficial for continual learning. In this paper, we explore the multistate metaplastic synapse characteristics in the context of high retention and reception of information.
arxiv