Results 81 to 90 of about 8,597 (225)

Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress

open access: yeseLife, 2018
Glucocorticoid receptor (GR) is crucial for signaling mediated by stress-induced high levels of glucocorticoids. The lateral nucleus of the amygdala (LA) is a key structure underlying auditory-cued fear conditioning.
Ran Inoue   +6 more
doaj   +1 more source

A Role for High Mobility Group Box 1 (HMGB1) Release in the Pathogenesis of Gastroesophageal Reflux Disease

open access: yesNeurogastroenterology &Motility, EarlyView.
Incubation of esophageal epithelial cells with a weakly acidic (pH 5) bile salt (deoxycholic acid) induces translocation of HMGB1 from the nucleus to the cytosol, and its subsequent release from the cell. This process can be ameliorated by pre‐treatment with the antioxidant, curcumin.
Tom Leech   +4 more
wiley   +1 more source

Temperoammonic stimulation depotentiates Schaffer collateral LTP via p38 MAPK downstream of adenosine A1 receptors [PDF]

open access: yes, 2019
We previously found that low-frequency stimulation of direct temperoammonic (TA) inputs to hippocampal area CA1 depotentiates previously established long-term potentiation in the Schaffer collateral (SC) pathway through complex signaling involving ...
Izumi, Yukitoshi, Zorumski, Charles F
core   +1 more source

Proposal for a New Classification of Rare Cancers Adopting Updated Histological Tumor Types

open access: yesPathology International, EarlyView.
We propose a new rare cancer classification system using the updated International Classification of Diseases for Oncology 3.2 coding system and the World Health Organization Classification of Tumors 5th edition. This list could serve as a diagnostic classifier to reliably distinguish various rare cancers for clinical applications.
Ryoko Rikitake   +8 more
wiley   +1 more source

Stress time-dependently influences the acquisition and retrieval of unrelated information by producing a memory of its own

open access: yesFrontiers in Psychology, 2015
Stress induces several temporally-guided waves of psychobiological responses that differentially influence learning and memory. One way to understand how the temporal dynamics of stress influence these cognitive processes is to consider stress, itself ...
Chelsea E Cadle, Phillip R Zoladz
doaj   +1 more source

Impairments of Synaptic Plasticity Induction Threshold and Network Oscillatory Activity in the Hippocampus Underlie Memory Deficits in a Non-Transgenic Mouse Model of Amyloidosis

open access: yesBiology, 2020
In early Alzheimer disease (AD) models synaptic failures and upstreaming aberrant patterns of network synchronous activity result in hippocampal-dependent memory deficits. In such initial stage, soluble forms of Amyloid-β (Aβ) peptides have been shown to
Jennifer Mayordomo-Cava   +9 more
doaj   +1 more source

Thinking Materially: Cognition as Extended and Enacted [PDF]

open access: yes, 2017
Human cognition is extended and enacted. Drawing the boundaries of cognition to include the resources and attributes of the body and materiality allows an examination of how these components interact with the brain as a system, especially over cultural ...
Overmann, Karenleigh A.
core  

Short-term immobilization influences use-dependent cortical plasticity and fine motor performance [PDF]

open access: yes, 2016
Short-term immobilization that reduces muscle use for 8-10h is known to influence cortical excitability and motor performance. However, the mechanisms through which this is achieved, and whether these changes can be used to modify cortical plasticity and
Evans, A.   +3 more
core   +1 more source

Olmesartan‐induced gastritis with no lower gastrointestinal symptoms: A case report

open access: yesDEN Open, Volume 6, Issue 1, April 2026.
Abstract A 74‐year‐old man with decreased appetite, weight, and heartburn was referred to our hospital. His medications included olmesartan. Esophagogastroduodenoscopy (EGD) revealed antral‐dominant erosive gastritis and nodular mucosa. A gastric biopsy revealed inflammatory cell infiltration.
Satoshi Kosaka   +2 more
wiley   +1 more source

Quantifying Hidden Architectural Patterns in Metaplastic Tumors by Calculating the Quadrant-Slope Index (QSI) [PDF]

open access: yesarXiv, 2017
The Quadrant-Slope Index (QSI) method was created in order to detect subtle patterns of organization in tumor images that have metaplastic elements, such as streams of spindle cells [1]. However, metaplastic tumors also have nuclei that may be aligned like a stream but are not obvious to the pathologist because the shape of the cytoplasm is unclear ...
arxiv  

Home - About - Disclaimer - Privacy