Results 81 to 90 of about 15,121 (239)

Impaired Motor Learning Following a Pain Episode in Intact Rats

Frontiers in Neurology, 2019
Motor learning and pain are important factors influencing rehabilitation. Despite being mostly studied independently from each other, important interactions exist between them in the context of spinal cord injury, whether to the spinal cord or the body ...
Maxime Huot-Lavoie, Windsor Kwan-Chun Ting, Maxime Demers, Catherine Mercier, Christian Ethier   +4 more
doaj   +1 more source

Convergent Neuronal Plasticity and Metaplasticity Mechanisms of Stress, Nicotine, and Alcohol.

Annual Review of Pharmacology and Toxicology, 2018
Stress and tobacco smoking are risk factors for alcoholism, but the underlying neural mechanisms are not well understood. Although stress, nicotine, and alcohol have broad, individual effects in the brain, some of their actions converge onto the same ...
A. Ostroumov, J. Dani
semanticscholar   +1 more source

Quantifying Hidden Architectural Patterns in Metaplastic Tumors by Calculating the Quadrant-Slope Index (QSI) [PDF]

arXiv, 2017
The Quadrant-Slope Index (QSI) method was created in order to detect subtle patterns of organization in tumor images that have metaplastic elements, such as streams of spindle cells [1]. However, metaplastic tumors also have nuclei that may be aligned like a stream but are not obvious to the pathologist because the shape of the cytoplasm is unclear ...
arxiv  

Voltage Gated Calcium Channel Activation by Backpropagating Action Potentials Downregulates NMDAR Function

Frontiers in Cellular Neuroscience, 2018
The majority of excitatory synapses are located on dendritic spines of cortical glutamatergic neurons. In spines, compartmentalized Ca2+ signals transduce electrical activity into specific long-term biochemical and structural changes.
Anne-Kathrin Theis, Balázs Rózsa, Balázs Rózsa, Gergely Katona, Dietmar Schmitz, Dietmar Schmitz, Dietmar Schmitz, Dietmar Schmitz, Dietmar Schmitz, Friedrich W. Johenning, Friedrich W. Johenning, Friedrich W. Johenning   +11 more
doaj   +1 more source

A Deep Intronic Splice Variant in COL1A1 Causing Osteogenesis Imperfecta Type II

American Journal of Medical Genetics Part A, Volume 197, Issue 5, May 2025.
ABSTRACT Osteogenesis imperfecta (OI) is a rare disease, hallmarked by bone fragility, multiple fractures, and deformities, and is commonly caused by pathogenic variants in the genes encoding type I collagen. Type II OI is the most severe form and is lethal in the perinatal period. Here, we report recurrence of perinatal lethal OI in two fetuses due to
Mackenna E. Schouw, Claudia A. L. Ruivenkamp, Tamara T. Koopmann, Gijs W. E. Santen, Peter G. J. Nikkels, Karin van der Tuin   +5 more
wiley   +1 more source

Diversity of Astroglial Effects on Aging- and Experience-Related Cortical Metaplasticity

Frontiers in Molecular Neuroscience, 2018
Activity-dependent regulation of synaptic plasticity, or metaplasticity, plays a key role in the adaptation of neuronal networks to physiological and biochemical changes in aging brain.
U. Lalo, Alexander Bogdanov, Y. Pankratov   +2 more
semanticscholar   +1 more source

Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy

MedComm, Volume 6, Issue 5, May 2025.
Reactive astrocytes release various molecules, which play a role in maintaining central nervous system (CNS) homeostasis. (1) Gliotransmitters, such as glutamate, γ‐aminobutyric acid (GABA), ATP, and D‐serine, are secreted by vesicular exocytosis. In addition, astrocytes can also release ATP and glutamate through (2) P2X7Rs, (3) connexin‐43 (Cx43 ...
Peter Illes, Patrizia Rubini, Henning Ulrich, Hai‐Yan Yin, Yong Tang   +4 more
wiley   +1 more source

A unifying theory of synaptic long-term plasticity based on a sparse distribution of synaptic strength

Frontiers in Synaptic Neuroscience, 2014
Long-term synaptic plasticity is fundamental to learning and network function. It has been studied under various induction protocols and depends on firing rates, membrane voltage, and precise timing of action potentials.These protocols show different ...
Daniel eKrieg, Jochen eTriesch
doaj   +1 more source

Cellular origins of mucinous ovarian carcinoma

The Journal of Pathology, Volume 266, Issue 1, Page 9-25, May 2025.
Abstract Mucinous ovarian carcinoma (MOC) is a rare histotype of epithelial ovarian cancer. Its origins are obscure: while many mucinous tumours in the ovary are metastases from the gastrointestinal tract, MOC can occur as an ovarian primary; however, the cell of origin is not well established.
Nicola S Meagher, Martin Köbel, Anthony N Karnezis, Aline Talhouk, Michael S Anglesio, Andrew Berchuck, Simon A Gayther, Paul PD Pharoah, Penelope M Webb, Susan J Ramus, Kylie L Gorringe   +10 more
wiley   +1 more source

Treatment-Resistant Major Depression:Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy

Frontiers in Psychiatry, 2015
Major depressive disorder (MDD) remains a huge personal and societal encumbrance. Particularly burdensome is a virulent subtype of MDD, treatment resistant major depression (TMRD), which afflicts 15-30% of MDD patients. There has been recent interest in
Charles eZorumski, Peter eNagele, Stephen James Mennerick, Charles eConway   +3 more
doaj   +1 more source