Results 41 to 50 of about 35,325 (238)

An optimized methodology for whole genome sequencing of RNA respiratory viruses from nasopharyngeal aspirates [PDF]

, 2018
Over the last decade, the number of viral genome sequences deposited in available databases has grown exponentially. However, sequencing methodology vary widely and many published works have relied on viral enrichment by viral culture or nucleic acid ...
Goya, Stephanie, Greninger, Alexander L., Marti, Marcelo Adrian, Mistchenko, Alicia Susana, Nabaes Jodar, Mercedes Soledad, Rojo, Gabriel Lihue, Tittarelli, Estefanía, Valinotto, Laura Elena, Viegas, Mariana, Zaiat, Jonathan Javier   +9 more
core   +2 more sources

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Sarcoidosis Presenting as Acute Respiratory Distress Syndrome. [PDF]

, 2018
Sarcoidosis is a multisystem granulomatous disease of unknown origin. It typically involves the lungs and mediastinal lymph nodes in a chronic fashion. However, acute syndrome has been reported possibly in response to systemic release of proinflammatory ...
Chan, Vincent, Lashari, Bilal, Raza, Ahmad, Ward, William   +3 more
core   +2 more sources

Global distribution and contexts of interactions between humans and non‐human primates: A systematic review

People and Nature, EarlyView.
Abstract Understanding the frequency and socio‐ecological drivers of contacts between humans and non‐human primates (NHPs) is crucial for enhancing coexistence that favours NHP conservation, while limiting negative consequences such as aggressions and cross‐species disease transmission.
Cristina Caparrós‐Vallcorba, Filipe Vieira Santos de Abreu, Claudio Azat, Julio A. Benavides   +3 more
wiley   +1 more source

Genome Sequence of a Divergent Avian Metapneumovirus from a Monk Parakeet (Myiopsitta monachus). [PDF]

, 2019
Here, we report the coding-complete genome sequence of an avian metapneumovirus from a monk parakeet (Myiopsitta monachus), identified by metagenomic next-generation sequencing during an investigation into a disease outbreak in a captive parrot breeding ...
Clubb, Susan, DeRisi, Joseph L, Retallack, Hanna   +2 more
core  

Interaction analysis of non‐bacterial respiratory pathogens during and after the coronavirus disease 2019 pandemic in two cities along the eastern coast of China

Pediatric Investigation, EarlyView.
What is Known • Co‐infections can influence pathogen replication, disease severity, and the duration of illness. • Co‐infection patterns and temporal correlations have been characterized among various respiratory viruses and atypical pathogens. What is New • A consistent negative correlation between influenza B and Mycoplasma pneumoniae suggests ...
Wanxian Ye, Jishan Zheng, Yungang Yang, Xinyue Song, Xiang Yuan, Lan Yang, Jian Yu, Hailin Zhang, Shunhang Wen   +8 more
wiley   +1 more source

Medical Gas Plasma Inactivates Adenoviruses via Capsid Oxidation

Small, EarlyView.
Oxidative modification of three adenoviral capsid proteins after gas plasma treatment. Schematic representation of the viral infection process, starting with the initial attachment of the virus via its fiber protein binding to the cellular receptors (CAR and/or CD46). In the secondary attachment step, the penton base binds to integrin structures on the
Anke Schmidt, Meike Heuser, Paul Schulan, Lea Miebach, Alice Martinet, Marcus Frank, Kristian Wende, Sander Bekeschus   +7 more
wiley   +1 more source

Establishment and application of a quadruple real-time RT-PCR for detecting avian metapneumovirus.

PLoS ONE, 2022
In order to develop an appropriate method for high-throughput detection of avian metapneumovirus, a quadruple real-time reverse-transcription polymerase chain reaction assay was established with four pairs of specific primers and four specific probes ...
Suchun Wang, Nan Jiang, Lijian Jiang, Qingye Zhuang, Qiong Chen, Guangyu Hou, Zhiyu Xiao, Ran Zhao, Yang Li, Chenglong Zhao, Fuyou Zhang, Jianmin Yu, Jinping Li, Hualei Liu, Fuliang Sun, Kaicheng Wang   +15 more
doaj   +1 more source

Prevalence and Diagnostic Challenge of Hemophagocytic Lymphohistiocytosis Syndrome in Critically Ill Patients

European Journal of Haematology, EarlyView.
ABSTRACT Background Hemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory syndrome. It is a severe condition with a challenging diagnosis in the intensive care unit (ICU), for which current recommendations rely on fulfilling five of eight HLH‐2004 criteria.
Claire Queffeulou, Mathieu Bellal, Suzanne Goursaud, Sylvain Chantepie, Damien du Cheyron   +4 more
wiley   +1 more source