Results 111 to 120 of about 561,058 (309)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Liver metastases from lung cancer

, 2015
With the improvement of techniques in liver surgery, indications to hepatic resections have been extended in the last decades to liver metastases secondary to non-colorectal, non-neuroendocrine tumors.
PINNA, ANTONIO DANIELE, RAVAIOLI, MATTEO, CESCON, MATTEO, ERCOLANI, GIORGIO, NERI, FLAVIA   +4 more
core  

Efeitos farmacológicos da suplementação dietética com arginina em ratos com tumor sólido de Walker 256

Archivos Latinoamericanos de Nutrición
Os efeitos da suplementação com arginina na dieta de portadores de câncer são controversos. O objetivo deste trabalho é avaliar os efeitos da suplementação dietética com arginina no cresciemnto tumoral, disserninação metastática, metabolismo de ...
M.R.C.G. Novaes, L.A.M. Lima, J.E.G. Ribeiro, A. V. Maga/hães, M. V. Sousa, L. Morhy   +5 more
doaj  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Patterns of CNS metastases in breast cancer patients

, 2016
In den letzten Jahren wurde eine steigende Inzidenz der ZNS-Metastasen beim Mammakarzinom verzeichnet. Diese sind ein limitierender Faktor für die Lebensqualität betroffener Patientinnen und mit einer eingeschränkten Prognose verbunden.
Scriba, Verena
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

International Field Testing of the Reliability and Validity of the EORTC QLQ-BM22 Module to Assess Health-Related Quality of Life in Patients With Bone Metastases

, 2014
BACKGROUND: The objective of this international field study was to test the reliability, validity, and responsiveness of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-BM22 module to assess health-related quality of life ...
Chow, Edward;Nguyen, Janet;Zhang, Liying;Tseng, Ling-Ming;Hou, Ming-Feng;Fairchild, Alysa;Vassiliou, Vassilios;Jesus-Garcia, Reynaldo;El-Din, Mohamed A. Alm;Kumar, Aswin;Forges, Fabien;Chie, Wei-Chu;Bottomley, Andrew, 季瑋珠   +1 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Quality of life measurement in bone metastases: A literature review

, 2008
Sukirtha Tharmalingam, Edward Chow, Kristin Harris, Amanda Hird, Emily SinclairRapid Response Radiotherapy Program, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, CanadaAbstract: Quality of life (QOL) has become ...
Edward Chow, Emily Sinclair, Sukirtha Tharmalingam, Kristin Harris, Amanda Hird   +4 more
core