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Markers of metastatic colorectal cancer

open access: yesGastroenterology Review, 2019
Metastatic colorectal cancer (CRC) is a major cause of cancer-related death. However, early diagnosis of CRC metastases offers a chance of long-term survival in as much as 40% of patients after curative treatment. Current guidelines are based on clinical
Piotr Myśliwiec   +2 more
doaj   +3 more sources

Metastatic Colorectal Cancer [PDF]

open access: yesCancers, 2021
International experts in the study of metastatic colorectal cancer (mCRC) present this series of 14 articles (eleven original articles and three literature reviews) [...]
Alessandro Passardi   +2 more
openaire   +2 more sources

Exosome-Derived ADAM17 Promotes Liver Metastasis in Colorectal Cancer

open access: yesFrontiers in Pharmacology, 2021
Exosomes derived from cancer cells are deemed important drivers of pre-metastatic niche formation at distant organs, but the underlying mechanisms of their effects remain largely unknow.
Jinbing Sun   +9 more
doaj   +1 more source

Clinical significance of frizzled homolog 3 protein in colorectal cancer patients. [PDF]

open access: yesPLoS ONE, 2013
Frizzled homolog 3 receptor was up-regulated in several gastrointestinal cancers such as esophageal and gastric cancers. Moreover, frizzled homolog 3 has recently reported to be expressed in colorectal adenoma specimens.
Sze Chuen Cesar Wong   +10 more
doaj   +1 more source

Interleukin-1 receptor antagonist inhibits metastatic potential by down-regulating CXCL12/CXCR4 signaling axis in colorectal cancer

open access: yesCell Communication and Signaling, 2021
Background The aim of this study was to investigate the co-operative role of CXCR4/CXCL12 axis and IL-1Ra in metastatic processes mechanism by interactions between colorectal cancer cells and stromal cells in their microenvironment. Methods Expression of
Jiachi Ma   +9 more
doaj   +1 more source

Metastatic colon cancer of an ovarian cancer origin mimicking primary colon cancer: A case report [PDF]

open access: yesKorean Journal of Clinical Oncology, 2018
Metastatic colorectal cancer is rare and its origins are difficult to define if the gross features of colorectal cancer mimic primary colorectal cancer.
Ji-Hyeon Park   +2 more
doaj   +1 more source

Clinical Response to Sorafenib in a Patient with Metastatic Colorectal Cancer and FLT3 Amplification

open access: yesCase Reports in Oncology, 2015
Background: A considerable number of patients with metastatic colorectal cancer progress after exhausting all approved standard therapies but maintain an adequate performance status and could be candidates for further treatment.
Raphael Brandão Moreira   +2 more
doaj   +1 more source

Bevacizumab plus Irinotecan-Based Regimens in the Treatment of Metastatic Colorectal Cancer [PDF]

open access: yes, 2010
Objectives: Bevacizumab is a monoclonal antibody that directly inhibits vascular endothelial growth factor, a key regulator of angiogenesis. Bevacizumab significantly improves progression-free and/or overall survival in metastatic colorectal cancer in ...
Heinemann, Volker, Hoff, Paulo M.
core   +1 more source

Leptin receptor (Ob-R) mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer

open access: yesBrazilian Journal of Medical and Biological Research, 2013
The objective of the present study was to investigate the effect of leptin on the progression of colorectal carcinoma to metastatic disease by analyzing the serum leptin concentration and Ob-R gene expression in colon cancer tissues.
N. Erkasap   +8 more
doaj   +3 more sources

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