Results 171 to 180 of about 309,141 (294)

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Explore the efficacy of microwave ablation combined with fruquintinib and tislelizumab in the treatment of metastatic colorectal cancer. [PDF]

Front Oncol
Qian W, Zhang H, Mo Y, Wu C, Liu J, Pen Y, Fang C, Meng J.   +7 more
europepmc   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

How to Integrate Surgery into the Multidisciplinary Treatment of Liver-Only Metastatic Colorectal Cancer. [PDF]

Cancers (Basel)
Pérez-Santiago L, Huntley Pascual D, Sánchez Lara JS, Huerta M, Dorcaratto D.   +4 more
europepmc   +1 more source

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

Advanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer. [PDF]

Mol Oncol
Siddiqui MT, Cottam MA, Mirza MB, Lewis KB, Ciombor KK, Washington MK, Idrees K.   +6 more
europepmc   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer. [PDF]

Cancer Discov
Avolio M, Leto SM, Sassi F, Lupo B, Grassi E, Catalano I, Zanella ER, Vurchio V, Cottino F, Tsantoulis PK, Lazzari L, Luraghi P, Ferri M, Galimi F, Berrino E, Bellomo SE, Viviani M, Sogari A, Mauri G, Tosi F, Cruciani F, Sartore-Bianchi A, Siena S, Borghi F, Torri V, Élez E, Tabernero J, Nieva M, Montagut C, Tarazona N, Cervantes A, Tejpar S, Bardelli A, Marchiò C, Marsoni S, Bertotti A, Trusolino L.   +36 more
europepmc   +1 more source

Engineered TIGIT‐Blockade Membrane Vesicles Synergize with Microwave Ablation to Mediate Liver Metastases Eradication

Advanced Science, EarlyView.
Microwave ablation (MWA) represents a highly effective and clinically significant therapeutic modality for the treatment of liver metastases. This study develops engineered cell membrane vesicles to specifically target the transition zone of MWA for liver metastases. This strategy can inhibit VEGF‐mediated immunosuppression, block CD155/TIGIT signaling
Shaoyue Li, Weichen Xu, Yuting Shen, Xuexia Shan, Jiawei Sun, Shisi Ding, Xiaodong Hou, Shaoning Zhang, Zhiyuan Niu, Taixia Wang, Xin Guan, Xiao Li, Weiwei Ren, Dou Du, Huixiong Xu, Wenwen Yue, Liping Sun   +16 more
wiley   +1 more source

Current perspectives and guidelines on liver transplantation for metastatic colorectal cancer. [PDF]

World J Transplant
Stoyanova M, Mircheva I, Chulkov I, Karamiteva M, Goranova Z, Simeonova V, Zashev M, Velikova T, Peruhova M.   +8 more
europepmc   +1 more source