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Potentially curable metastatic colorectal cancer
Current Oncology Reports, 2008Although patients with metastatic colorectal cancer have historically had a uniformly dismal prognosis, recent advances in chemotherapeutics and surgical techniques allow many patients to be treated with the potential for long-term survival and cure.
Matthew, Katz, Jean-Nicolas, Vauthey
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HER2-Positive Metastatic Colorectal Cancer
Current Treatment Options in OncologyTargeted treatment strategies are available for human epidermal growth factor receptor 2 (HER2)-positive (amplified and/or overexpressed) metastatic colorectal cancer (mCRC), and HER2 testing is indicated in patients with mCRC. At present, standard of care first-line treatment for those with HER2-positive mCRC remains chemotherapy in combination with ...
Hannah R, Robinson +2 more
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Laparoscopy for metastatic colorectal cancer
Surgical Oncology, 2007Patients with metastatic disease from colorectal cancer are now living twice as long as they were one decade ago. With this increasing life expectancy, we are beginning to see these patients strive for an acceptable and improved quality of life. Medical advances have led to unanswered questions regarding the role of surgery in metastatic colorectal ...
Bradley J, Champagne, Conor P, Delaney
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Chemotherapy in metastatic colorectal cancer
Techniques in Coloproctology, 2004The treatment of patients with metastatic colorectal cancer (MCRC) has changed dramatically over the years. 5-Fluorouracil (5FU)-based therapies have been routinely included in treatment regimens for colorectal cancer for the past 40 years. A number of options are available to clinicians for the treatment of patients relapsing after surgical excision ...
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Plasticity in metastatic colorectal cancer
Developmental CellGenetic mutations cause colorectal cancer (CRC) initiation, but their contribution to metastasis and therapy resistance is less clear. In a recent issue of Nature, Moorman et al.1 use single-cell transcriptome sequencing to map the changes in cancer cell state (cell phenotypes) that occur through CRC progression.
Frederick J H, Whiting, Trevor A, Graham
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Chemotherapy for metastatic colorectal cancer
Cancer, 1992The systemic management of patients with colorectal cancer continues to focus on the use of 5-fluorouracil (5-FU). In the setting of metastatic disease, parenteral 5-FU has been shown to be superior to oral 5-FU; however, survival duration seems similar whether such parenteral 5-FU is administered in a "loading," weekly, or continuous infusion manner ...
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Colorectal cancer statistics, 2023
Ca-A Cancer Journal for Clinicians, 2023Rebecca L Siegel +2 more
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Clinical management of metastatic colorectal cancer in the era of precision medicine
Ca-A Cancer Journal for Clinicians, 2022Fortunato Ciardiello +2 more
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