Results 41 to 50 of about 309,141 (294)

Metastatic Colorectal Cancer 2.0

Cancers
Colorectal cancer (CRC) ranks third in frequency among cancers diagnosed in males and second in females [...]
Alessandro Passardi, Giorgia Marisi, Paola Ulivi   +2 more
openaire   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Update on Targeted Therapy and Immunotherapy for Metastatic Colorectal Cancer

Cells
Metastatic colorectal cancer remains a deadly malignancy and is the third leading cause of cancer-related death. The mainstay of treatment for metastatic colorectal cancer is chemotherapy, but unfortunately, even with recent progress, overall survival is
Patrick W. Underwood, Samantha M. Ruff, Timothy M. Pawlik   +2 more
doaj   +1 more source

Targeted drugs in the second line anticancer therapy of disseminated colorectal cancer

Медицинский совет, 2015
For many years, colorectal cancer has been one of the most common tumor diseases in the world. However, treatment outcomes for patients with metastatic colorectal cancer have long remained quite poor. The development of targeted therapy had a significant
K. A. Vorontsova, E. V. Chernoglazova, G. V. Vyshinskaya   +2 more
doaj   +1 more source

Hepatic resection for metastatic colorectal adenocarcinoma: A proposal of a prognostic scoring system [PDF]

, 1999
Background: Hepatic resection for metastatic colorectal cancer provides excellent longterm results in a substantial proportion of patients. Although various prognostic risk factors have been identified, there has been no dependable staging or prognostic ...
Bonham, AC, Dodson, F, Dvorchik, I, Fung, JJ, Gayowski, TJ, Geller, DA, Iwatsuki, S, Madariaga, JR, Starzl, TE, Wallis Marsh, J   +9 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Multimodal Treatment of Metastatic Rectal Cancer in a Young Patient: Case Report and Literature Review

Medicina
Metastatic colorectal cancer requires a multidisciplinary and individualized approach. Herein, we reported the case of a young woman diagnosed with metastatic rectal cancer who received an individualized multimodal treatment strategy that resulted in a ...
Ionuț Popescu, Ana-Maria Dudău, Simona Dima, Vlad Herlea, Vlad M. Croitoru, Ioana Mihaela Dinu, Monica Miron, Ioana Lupescu, Irina M. Croitoru-Cazacu, Radu Dumitru, Adina Emilia Croitoru   +10 more
doaj   +1 more source

MicroRNA-203 predicts human survival after resection of colorectal liver metastasis. [PDF]

, 2016
BackgroundResection of colorectal liver metastasis (CRLM) can be curative. Predicting which patients may benefit from resection, however, remains challenging. Some microRNAs (miRNAs) become deregulated in cancers and contribute to cancer progression.
D'Angelica, Michael I, Goodarzi, Hani, Jarnagin, William R, Kingham, T Peter, Konstantinidis, Ioannis T, Kuk, Deborah, Nguyen, Hoang CB, Sadot, Eran, Saltz, Leonard, Shia, Jinru, Tavazoie, Sohail F, Zhang, Steven, Zheng, Jian   +12 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Review: Systemic treatment of advanced colorectal cancer: Tailoring therapy to the tumor

Therapeutic Advances in Gastroenterology, 2008
Colorectal cancer is a prevalent disease in Western countries. While prevention through screening is the best approach to combat the development of colorectal cancer through the removal of precursor adenomas, many patients present with advanced disease ...
John M. Carethers
doaj   +1 more source