Results 1 to 10 of about 885,175 (334)

Cutaneous melanoma metastasis to the large and small intestine: A case report and review of the literature [PDF]

Acta Stomatologica Naissi, 2023
Introduction: Metastatic melanoma rarely metastasizes to the gastrointestinal tract (GIT). However, melanoma in the gastrointestinal tract is usually of metastatic origin, given that primary melanomas in this location are extremely uncommon.
Denčić Tijana V., Jovičić-Milentijević Maja V., Vidović Nataša T., Petrović Aleksandar S., Mitić Dušan B.   +4 more
doaj   +1 more source

An Evaluation of the Anti-Carcinogenic Response of Major Isothiocyanates in Non-Metastatic and Metastatic Melanoma Cells

Antioxidants, 2021
Malignant melanoma is one of the most deadly types of solid cancers, a property mainly attributed to its highly aggressive metastatic form. On the other hand, different classes of isothiocyanates, a class of phytochemicals, present in cruciferous ...
Melina Mitsiogianni, Sotiris Kyriakou, Ioannis Anestopoulos, Dimitrios T. Trafalis, Maria V. Deligiorgi, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis   +7 more
doaj   +1 more source

Epidemiology, management, and treatment outcomes of metastatic spinal melanoma

World Neurosurgery: X, 2023
Metastatic spinal melanoma is a rare and aggressive disease process with poor prognosis. We review the literature on metastatic spinal melanoma, focusing on its epidemiology, management, and treatment outcomes.
David X. Zheng, Sauson Soldozy, Kathleen M. Mulligan, Melissa A. Levoska, Erin F. Cohn, Ariel Finberg, Peter Alsaloum, Thomas B. Cwalina, Simon J. Hanft, Jeffrey F. Scott, Luke D. Rothermel, Vinod E. Nambudiri   +11 more
doaj   +1 more source

miR-138-5p induces aggressive traits by targeting Trp53 expression in murine melanoma cells, and correlates with poor prognosis of melanoma patients

Neoplasia: An International Journal for Oncology Research, 2021
Deregulation of miRNAs contributes to the development of distinct cancer types, including melanoma, an aggressive form of skin cancer characterized by high metastatic potential and poor prognosis. The expression of a set of 580 miRNAs was investigated in
Adriana Taveira da Cruz, Aline Hunger, Fabiana Henriques Machado de Melo, Ana Carolina Monteiro, Geneviève Catherine Paré, Dulce Lai, Débora Kristina Alves-Fernandes, Ana Luisa Pedroso Ayub, Esteban Mauricio Cordero, José Franco da Silveira Filho, Regine Schneider-Stock, Bryan Eric Strauss, Victor Tron, Miriam Galvonas Jasiulionis   +13 more
doaj   +1 more source

Paired primary and metastatic lesions of patients with ipilimumab-treated melanoma: high variation in lymphocyte infiltration and HLA-ABC expression whereas tumor mutational load is similar and correlates with clinical outcome

Journal for ImmunoTherapy of Cancer, 2022
Background Immune checkpoint inhibitors (ICI) can lead to long-term responses in patients with metastatic melanoma. Still many patients with melanoma are intrinsically resistant or acquire secondary resistance.
Kalijn Bol, Johannes Textor, Carl G Figdor, I Jolanda M de Vries, Lieke L van der Woude, Mark A J Gorris, Kiek Verrijp, Leonie I Kroeze, Avital L Amir, Jelena Meek   +9 more
doaj   +1 more source

MicroRNA-107 is a novel tumor suppressor targeting POU3F2 in melanoma

Biological Research, 2020
Background Melanoma is one of the major types of skin cancer. The metastatic melanoma is among the most lethal forms of malignant skin tumors. We hereby aimed to characterize a novel microRNA (miR) in the metastatic melanoma model.
Guizhi Zhao, Zhili Wei, Yang Guo
doaj   +1 more source

Treatment of Metastatic Melanoma at First Diagnosis: Review of the Literature

Life, 2022
Metastatic melanoma (MM) is a pathological entity with a very poor prognosis that, until a few decades ago, had a low response rate to systemic treatments. Fortunately, in the last few years, new therapies for metastatic melanoma have emerged. Currently,
Miguel-Angel Berciano-Guerrero, Mora Guardamagna, Elisabeth Perez-Ruiz, Jose-Miguel Jurado, Isabel Barragán, Antonio Rueda-Dominguez   +5 more
doaj   +1 more source

Disseminated Melanoma Cells Transdifferentiate into Endothelial Cells in Intravascular Niches at Metastatic Sites

Cell Reports, 2020
Summary: Tumor cell plasticity, including transdifferentiation, is thought to be a key driver of therapy failure, tumor dormancy, and metastatic dissemination.
Xiaoshuang Li, Panagiotis Karras, Raúl Torres, Florian Rambow, Joost van den Oord, Jean-Christophe Marine, Lidia Kos   +6 more
doaj   +1 more source

Extracellular vesicles microRNA-592 of melanoma stem cells promotes metastasis through activation of MAPK/ERK signaling pathway by targeting PTPN7 in non-stemness melanoma cells

Cell Death Discovery, 2022
Melanoma, one of the most aggressive malignancies, its high mortality and low survival rates are associated with effective metastatic colonization. Melanoma metastasis hinges on the bidirectional cell-cell communication within the complex metastatic ...
Yuhan Zhang, Yan Chen, Lei Shi, Jie Li, Wenjuan Wan, Bowen Li, Doudou Liu, Xiaoshuang Li, Yuting Chen, Meng Xiang, Hao Chen, Bin Zeng, H. Rosie Xing, Jianyu Wang   +13 more
doaj   +1 more source

Cardiac metastatic melanoma [PDF]

BMJ Case Reports, 2016
We describe the case of a 55-year-old woman presenting with a recent onset of mild cough and no other specific cardiovascular symptoms, and with a normal examination. Salient past medical history included BRAF-positive melanoma resected from the small bowel with abdominal, left inguinal and pulmonary metastases, 2 years prior.
Jay Ramchand, Geoffrey R Wong, Matias B Yudi, Stephen Sylivris   +3 more
openaire   +2 more sources