Results 101 to 110 of about 885,175 (334)

Managing Metastatic Melanoma in 2022: A Clinical Review.

JCO Oncology Practice, 2022
B. Switzer, I. Puzanov, J. Skitzki, L. Hamad, M. Ernstoff   +4 more
semanticscholar   +1 more source

Nanomaterial‐Integrated Fiber Neural Probes for Deep Brain Monitoring and Modulation: Challenges and Opportunities

Advanced Functional Materials, EarlyView.
The article presents nanomaterial‐integrated fiber neural probes as innovative tools for deep brain molecular sensing, neural stimulation, and temperature monitoring. It examines breakthroughs in SERS‐based biomolecule detection, thermoplasmonic activation, and luminescent thermometry, alongside strategies to overcome stability, specificity, and ...
Di Zheng, Yang Li, Muhammad Fayyaz Kashif, Linda Piscopo, Massimo De Vittorio, Ferruccio Pisanello   +5 more
wiley   +1 more source

Two synchronous lung metastases from malignant melanoma: the same patient but different morphological patterns

European Journal of Radiology Open, 2019
Malignant melanoma is an aggressive cancer with a high metastatic potential. Among the multiple sites of metastatic disease, the lung is one of the most frequently involved sites.
Andrea Borghesi, Andrea Tironi, Silvia Michelini, Alessandra Scrimieri, Diego Benetti, Roberto Maroldi   +5 more
doaj   +1 more source

NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma [PDF]

, 2017
Zili Zhai, Wen-Ting Liu, Manjinder Kaur, Y. Luo, Joanne Domenico, Jenny Mae Samson, Yiqun G. Shellman, David A. Norris, Charles A. Dinarello, Richard A. Spritz, Mayumi Fujita   +10 more
openalex   +1 more source

Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/K-mutant melanoma: long-term survival and safety analysis of a phase 3 study

Annals of Oncology, 2017
Background Previous analysis of COMBI-d (NCT01584648) demonstrated improved progression-free survival (PFS) and overall survival (OS) with combination dabrafenib and trametinib versus dabrafenib monotherapy in BRAF V600E/K-mutant metastatic melanoma ...
G. Long, K. Flaherty, D. Stroyakovskiy, H. Gogas, E. Levchenko, F. D. Braud, J. Larkin, Claus Garbe, T. Jouary, A. Hauschild, V. Chiarion-Sileni, C. Lebbé, M. Mandalà, M. Millward, A. Arance, I. Bondarenko, J. Haanen, J. Hansson, J. Utikal, V. Ferraresi, Peter Mohr, V. Probachai, D. Schadendorf, P. Nathan, C. Robert, A. Ribas, M. Davies, S. Lane, J. Legos, B. Mookerjee, J. Grob   +30 more
semanticscholar   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Single-cell transcriptomics and functional validation revealed PLEKHA5-L as a promoter of growth and migration in brain metastatic melanoma cells

Frontiers in Oncology
BackgroundMelanoma brain metastasis is an lethal event. Investigating the molecules that potentially promoted melanoma metastasis is important for targeted therapy.MethodsThe transcriptional profiles of totaling 7 melanoma samples, including 4 primary ...
Xiaogen Tang, Tingting Lei, Boya Huang, Guangjie Wu, Yizhen Tian, Jian Xiang, Dongwei Fu, Hongyi Zhang   +7 more
doaj   +1 more source

Primary and Metastatic Melanoma With NTRK Fusions

American Journal of Surgical Pathology, 2018
A number of oncogenic driver mutations have been identified in melanocytic nevi and melanoma, but translocations also play a role in tumorigenesis and provide potential therapeutic targets for malignant lesions.
C. Lezcano, A. Shoushtari, C. Ariyan, T. Hollmann, K. Busam   +4 more
semanticscholar   +1 more source

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source