Results 121 to 130 of about 885,175 (334)

Melanoma Development and Progression Are Associated with Rad6 Upregulation and β-Catenin Relocation to the Cell Membrane

Journal of Skin Cancer, 2014
We have previously demonstrated that Rad6 and β-catenin enhance each other's expression through a positive feedback loop to promote breast cancer development/progression. While β-catenin has been implicated in melanoma pathogenesis, Rad6 function has not
Karli Rosner, Darius R. Mehregan, Evangelia Kirou, Judith Abrams, Seongho Kim, Michelle Campbell, Jillian Frieder, Kelsey Lawrence, Brittany Haynes, Malathy P. V. Shekhar   +9 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

Cell, 2016
Willy Hugo, J. Zaretsky, Lu Sun, Chunying Song, B. H. Moreno, S. Hu-Lieskovan, B. Berent-Maoz, Jia Pang, B. Chmielowski, Grace Cherry, E. Seja, Shirley H. Lomeli, X. Kong, M. Kelley, J. Sosman, Douglas B. Johnson, A. Ribas, R. Lo   +17 more
semanticscholar   +2 more sources

Solitary melanoma in the pineal gland: Differentiating primary from metastatic melanoma in the central nervous system

Interdisciplinary Neurosurgery
Primary melanoma of the pineal gland is exceedingly rare. Melanoma in the central nervous system (CNS) is far more likely to be a metastasis from a cutaneous primary; however, in a patient with no known history of melanoma, differentiating metastatic ...
Denesh Selvarajah, Hana Angelia Kawatu, Peter Mews, Elizabeth C Paver   +3 more
doaj   +1 more source

Remote‐Controllable Immune‐Priming Spot Formation Via Nanocomplexed Hydrogel‐Assisted Histotripsy: Immunoasis

Advanced Materials, EarlyView.
A novel immunotherapeutic strategy combines injectable, adjuvant‐loaded hydrogels with externally controlled histotripsy to create immune‐priming sites within tumors. This approach generates millimeter‐sized immune‐activated lesions with flexible, patient‐tailored treatment scheduling, enabling precise immune activation through tumor ablation‐mediated ...
Sung Hoon Kim, Wonseok Choi, Yurim Kim, Hyeongmin Kim, Gu Won Jeong, Hyewon Park, Inchan Youn, Yoon Park, Sungmin Han, Young‐Min Kim   +9 more
wiley   +1 more source

IVC thrombectomy and atrial tumor removal with radical nephrectomy and adrenalectomy for metastatic melanoma with immune checkpoint inhibitor therapy: A case report and literature review

Urology Case Reports
Caval thrombus with intracardiac involvement is a rare condition that is associated with renal cell carcinoma. Few reports in literature describe this presentation with metastatic melanoma.
Michael Raver, Bianca DeAgresta, Alexandra Della Pia, Cara Wong, Grace Basralian, Jennifer Nguyen, Nitin Yerram   +6 more
doaj   +1 more source

Case Report: Development of Hodgkin's Disease in Patient Receiving Long-Term Administration of Dacarbazine and Interleukin-2 for Metastatic Melanoma [PDF]

, 1990
L. E. FLAHERTY, R. C. Schwert, E. L. Mich, Bruce G. Redman   +3 more
openalex   +1 more source

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

Advanced Science, EarlyView.
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang, Siqi Ren, Yuhui Li, Rongxi Chen, Ling Qiu, Yongmei Tan, Suling Chen, Huiqian Wu, Lianxi Mai, Xiao Tan, Xin Liu, Peisheng Liang, Shijia Kuang, Liansheng Wang, Jingkang Liu, Jintao Li, Yanyan Li, Qiuping Xu, Yongzhi Su, Yuehai Luo, Binyan Wu, Zijing Huang, Haotian Cao, Qunxing Li, Jinsong Li, Tianjun Lan   +25 more
wiley   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Science, 2016
I. Tirosh, B. Izar, S. Prakadan, M. Wadsworth, D. Treacy, John J. Trombetta, Asaf Rotem, Christopher Rodman, C. Lian, G. Murphy, M. Fallahi‐Sichani, K. Dutton-Regester, Jia-Ren Lin, Ofir Cohen, Parin Shah, Diana Lu, Alex S Genshaft, T. Hughes, Carly G. K. Ziegler, S. Kazer, A. Gaillard, Kellie E. Kolb, A. Villani, Cory M. Johannessen, A. Andreev, E. V. Van Allen, M. Bertagnolli, P. Sorger, R. Sullivan, K. Flaherty, Dennie T. Frederick, Judit Jané-Valbuena, Charles H. Yoon, O. Rozenblatt-Rosen, A. Shalek, A. Regev, L. Garraway   +36 more
semanticscholar   +1 more source