Results 11 to 20 of about 284,307 (179)

Combination immunotherapy induces distinct T-cell repertoire responses when administered to patients with different malignancies. [PDF]

, 2020
BackgroundCTLA-4 blockade with ipilimumab is Food and Drug Administration-approved for melanoma as a monotherapy and has been shown to modulate the circulating T-cell repertoire.
Cham, Jason, Fong, Grant, Fong, Lawrence, He, Tao, Kwek, Serena, Oh, David Y, Paciorek, Alan, Zhang, Li   +7 more
core   +1 more source

Extracellular vesicles microRNA-592 of melanoma stem cells promotes metastasis through activation of MAPK/ERK signaling pathway by targeting PTPN7 in non-stemness melanoma cells

Cell Death Discovery, 2022
Melanoma, one of the most aggressive malignancies, its high mortality and low survival rates are associated with effective metastatic colonization. Melanoma metastasis hinges on the bidirectional cell-cell communication within the complex metastatic ...
Yuhan Zhang, Yan Chen, Lei Shi, Jie Li, Wenjuan Wan, Bowen Li, Doudou Liu, Xiaoshuang Li, Yuting Chen, Meng Xiang, Hao Chen, Bin Zeng, H. Rosie Xing, Jianyu Wang   +13 more
doaj   +1 more source

Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma. [PDF]

, 2017
Patients with metastatic uveal melanoma usually die within 1 year of diagnosis, emphasizing an urgent need to develop new treatment strategies. The liver is the most common site of metastasis.
Aplin, Andrew E., Cheng, Hanyin, Chua, Vivian, Davies, Michael A., Kageyama, Ken, Liao, Connie, Purwin, Timothy J., Sato, Takami, Terai, Mizue   +8 more
core   +2 more sources

Mambalgin-2 Inhibits Growth, Migration, and Invasion of Metastatic Melanoma Cells by Targeting the Channels Containing an ASIC1a Subunit Whose Up-Regulation Correlates with Poor Survival Prognosis

Biomedicines, 2021
Melanoma is an aggressive cancer characterized by the acidification of the extracellular environment. Here, we showed for the first time that extracellular media acidification increases proliferation, migration, and invasion of patient-derived metastatic
Maxim L. Bychkov, Artem V. Kirichenko, Mikhail A. Shulepko, Irina N. Mikhaylova, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova   +5 more
doaj   +1 more source

BRAFV600E mutation positive metastatic melanoma in a young woman treated with anti-BRAF/anti MEK combination: a case report [PDF]

, 2015
The recent Combi-v [1] and Combi-d [2,3], phase III randomized trials, showed, respectively, an OS benefit with Dabrafenib/Trametinib combination versus Vemurafenib and an improvement in PFS and ORR with the same combination versus Dabrafenib alone ...
CORTESI, Enrico, GIOVANNONI, SARA, Giuliana, Caprio, MEZI, Silvia, MODICA, DANIELA, URBANO, FEDERICA, VERKHOVSKAIA, SOFIA   +6 more
core   +2 more sources

METASTATIC MELANOMA WITHOUT CLINICALLY EVIDENT PRIMARY TUMOR

Сибирский онкологический журнал, 2017
The purpose of the study was to systematize the data available in the modern literature on the diagnosis and treatment of metastatic melanoma without clinically evident primary tumor. Materials and methods.
V. Sh. Rzaeva, G. I. Gafton, V. V. Anisimov, Y. V. Semiletova, M. Yu. Myasnyankin, I. G. Gafton   +5 more
doaj   +1 more source

High-Metastatic Melanoma Cells Promote the Metastatic Capability of Low-Metastatic Melanoma Cells via Exosomal Transfer of miR-411-5p

Frontiers in Oncology, 2022
Melanoma is characterized by high rate of metastasis and mortality. Effective management of metastatic melanoma depends on renewed mechanistic understanding underlying melanoma progression and metastasis.
Hao Chen, Hao Chen, Bin Zeng, Xiaoshuang Li, Xiaoshuang Li, Qiting Zhao, Doudou Liu, Doudou Liu, Yuting Chen, Yuting Chen, Yuhan Zhang, Yuhan Zhang, Jianyu Wang, H. Rosie Xing, H. Rosie Xing   +14 more
doaj   +1 more source

Osteopontin and `Melanoma Inhibitory Activity': Comparison of Two Serological Tumor Markers in Metastatic Uveal Melanoma Patients [PDF]

, 2009
Background: Evaluation of the protein osteopontin (OPN) as a potential new marker in comparison to melanoma inhibitory activity (MIA) for screening and detection of metastatic uveal melanoma. Methods: Plasma levels of 32 patients with uveal melanoma were
Haritoglou, Christos, Haritoglou, Ingrid, Hein, Ruediger, Maier, Tanja, Schaller, Ulrich Christoph, Wolf, Armin   +5 more
core   +1 more source

An immunotherapy survivor population: health-related quality of life and toxicity in patients with metastatic melanoma treated with immune checkpoint inhibitors [PDF]

, 2019
© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium ...
Au, L, Chauhan, D, Edmonds, K, Gore, M, Hughes, P, Husson, O, Lai, Z, Larkin, J, Lingard, K, Ludlow, A, Lynch, J, Mann, J, Mclean, E, O'Reilly, A, Pattison, N, Teh, JJ, Turajlic, S, Wiseman, T   +17 more
core   +3 more sources

Epidermotropic metastatic melanoma with perilesional depigmentation in an Indian male

Indian Journal of Dermatology, 2013
Melanoma is a rare form of cutaneous malignancy encountered in the dark skin population. Epidermotropic metastatic melanoma is a rare form of cutaneous metastatic melanoma which can mimic primary melanoma on histopathology.
Bhavana Doshi, Sunanda Mahajan, Uday S Khopkar, Vidya Kharkar, Prachi Agarwal   +4 more
doaj   +1 more source