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Metastatic melanoma [PDF]

CA: A Cancer Journal for Clinicians, 2020
Melanoma is the most serious type of skin cancer1 and many times it is caused by damage to the DNA in skin cells. This damage to the DNA (often called a gene mutation) can cause cancerous tumors to form in the skin.
Ragini R, Kudchadkar, Michael C, Lowe, Mohammad K, Khan, Stephanie M, McBrien   +3 more
semanticscholar   +5 more sources

Lifileucel, a Tumor-Infiltrating Lymphocyte Therapy, in Metastatic Melanoma

Journal of Clinical Oncology, 2021
PURPOSE Effective treatment options are limited for patients with advanced (metastatic or unresectable) melanoma who progress after immune checkpoint inhibitors and targeted therapies.
A. Sarnaik, O. Hamid, N. Khushalani, K. Lewis, T. Medina, H. Kluger, Sajev Thomas, Evidio Domingo-Musibay, A. Pavlick, E. Whitman, S. Martı́n-Algarra, P. Corrie, B. Curti, J. Oláh, J. Lutzky, J. Weber, J. Larkin, W. Shi, T. Takamura, M. Jagasia, Harry Qin, Xiao Wu, C. Chartier, Friedrich Graf Finckenstein, M. Fardis, J. Kirkwood, J. Chesney   +26 more
semanticscholar   +1 more source

Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma.

New England Journal of Medicine, 2021
BACKGROUND Uveal melanoma is a disease that is distinct from cutaneous melanoma, with a low tumor mutational burden and a 1-year overall survival of approximately 50% in patients with metastatic uveal melanoma.
P. Nathan, J. Hassel, P. Rutkowski, J. Baurain, M. Butler, M. Schlaak, R. Sullivan, S. Ochsenreither, R. Dummer, J. Kirkwood, A. Joshua, J. Sacco, A. Shoushtari, M. Orloff, J. Piulats, M. Milhem, A. Salama, B. Curti, L. Demidov, L. Gastaud, C. Mauch, Melinda L. Yushak, R. Carvajal, O. Hamid, S. Abdullah, C. Holland, H. Goodall, S. Piperno-Neumann   +27 more
semanticscholar   +1 more source

Retrograde Balloon-Assisted Deep Enteroscopy in the Diagnosis of Metastatic Melanoma

Case Reports in Gastrointestinal Medicine, 2021
A 74-year-old male with a history of metastatic melanoma presents with persistently abnormal small bowel findings on PET-CT scan. The patient had persistent FDG uptake near the ileocolic junction on imaging, concerning for metastatic melanoma.
William Barge, Mark R. Albertini, Christopher Cold, Daniel Abbott, Deepak Gopal   +4 more
doaj   +1 more source

Mambalgin-2 Inhibits Growth, Migration, and Invasion of Metastatic Melanoma Cells by Targeting the Channels Containing an ASIC1a Subunit Whose Up-Regulation Correlates with Poor Survival Prognosis

Biomedicines, 2021
Melanoma is an aggressive cancer characterized by the acidification of the extracellular environment. Here, we showed for the first time that extracellular media acidification increases proliferation, migration, and invasion of patient-derived metastatic
Maxim L. Bychkov, Artem V. Kirichenko, Mikhail A. Shulepko, Irina N. Mikhaylova, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova   +5 more
doaj   +1 more source

Epidermotropic metastatic melanoma with perilesional depigmentation in an Indian male

Indian Journal of Dermatology, 2013
Melanoma is a rare form of cutaneous malignancy encountered in the dark skin population. Epidermotropic metastatic melanoma is a rare form of cutaneous metastatic melanoma which can mimic primary melanoma on histopathology.
Bhavana Doshi, Sunanda Mahajan, Uday S Khopkar, Vidya Kharkar, Prachi Agarwal   +4 more
doaj   +1 more source

METASTATIC MELANOMA WITHOUT CLINICALLY EVIDENT PRIMARY TUMOR

Сибирский онкологический журнал, 2017
The purpose of the study was to systematize the data available in the modern literature on the diagnosis and treatment of metastatic melanoma without clinically evident primary tumor. Materials and methods.
V. Sh. Rzaeva, G. I. Gafton, V. V. Anisimov, Y. V. Semiletova, M. Yu. Myasnyankin, I. G. Gafton   +5 more
doaj   +1 more source

High-Metastatic Melanoma Cells Promote the Metastatic Capability of Low-Metastatic Melanoma Cells via Exosomal Transfer of miR-411-5p

Frontiers in Oncology, 2022
Melanoma is characterized by high rate of metastasis and mortality. Effective management of metastatic melanoma depends on renewed mechanistic understanding underlying melanoma progression and metastasis.
Hao Chen, Hao Chen, Bin Zeng, Xiaoshuang Li, Xiaoshuang Li, Qiting Zhao, Doudou Liu, Doudou Liu, Yuting Chen, Yuting Chen, Yuhan Zhang, Yuhan Zhang, Jianyu Wang, H. Rosie Xing, H. Rosie Xing   +14 more
doaj   +1 more source

Extracellular Vesicles Derived from Acidified Metastatic Melanoma Cells Stimulate Growth, Migration, and Stemness of Normal Keratinocytes

Biomedicines, 2022
Metastatic melanoma is a highly malignant tumor. Melanoma cells release extracellular vesicles (EVs), which contribute to the growth, metastasis, and malignancy of neighboring cells by transfer of tumor-promoting miRNAs, mRNA, and proteins.
Maxim L. Bychkov, Artem V. Kirichenko, Irina N. Mikhaylova, Alexander S. Paramonov, Evgeny V. Yastremsky, Mikhail P. Kirpichnikov, Mikhail A. Shulepko, Ekaterina N. Lyukmanova   +7 more
doaj   +1 more source

CHRNA1 and its correlated-myogenesis/cell cycle genes are prognosis-related markers of metastatic melanoma

Biochemistry and Biophysics Reports, 2023
Nicotinic acetylcholine receptors (CHRNs) expression and their critical role in various types of cancer have been reported. However, it is still unclear which CHRNs and their associated genes play essential roles in metastasis in melanoma patients. Here,
Mohamed Nabil Bakr, Haruko Takahashi, Yutaka Kikuchi   +2 more
doaj   +1 more source