Results 201 to 210 of about 885,175 (334)

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

Identification of the immune subtypes associated with the prognosis and immunotherapy of metastatic melanoma. [PDF]

Transl Cancer Res
Zhang F, Zhang X, Su H, Hong L, Wu Y, Shu C.   +5 more
europepmc   +1 more source

Phase II trial on nivolumab plus hypofractionated radiotherapy in patients with metastatic mucosal melanoma: PORTER-M3 trial

Motoo Nomura, Michio Yoshimura, Tomoya Yokota, Shogen Boku, Isao Oze, Hideki Ishikawa, Manabu Muto   +6 more
openalex   +1 more source

A Trial of Chemoimmunotherapy Using Paclitaxel, Mitoxantrone, IFN-.ALPHA. and Cepharanthin for Metastatic Malignant Melanoma.

, 2002
安西 三郎, 内林 義知, Toshihiro Sato, Hiroto Terashi, 高安 進, Sakuhei Fujiwara, 在永 光行, 中城 正夫, 三浦 隆, Tomiko Yamaguchi   +9 more
openalex   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

Complete Junctional Scotoma Secondary to Metastatic Melanoma: A Rapidly Progressive Presentation. [PDF]

Cureus
Boguslavskiy R, Tharp M, Gan W, Swerdloff MA.   +3 more
europepmc   +1 more source

Table 3 from Incidence and Management of Adverse Events Associated with Tebentafusp Treatment in Metastatic Uveal Melanoma: Pooled Safety Analysis of 410 Patients

Takami Sato, Marcus O. Butler, Sophie Piperno‐Neumann, Jessica C. Hassel, Paul Nathan, Alexander N. Shoushtari, Piotr Rutkowski, Richard D. Carvajal, Jean‐François Baurain, Max Schlaak, Josep M. Piulats, Ryan J. Sullivan, Sebastian Ochsenreither, Reinhard Dummer, John M. Kirkwood, Alexandra P. Ikeguchi, Anthony M. Joshua, Mark R. Middleton, Ramakrishna Edukulla, Constance Pfeiffer, Joseph J. Sacco   +20 more
openalex   +1 more source

Concordance and Discordance Rates of V-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF) ^V600E Status in Metastatic against Primary Lesion of Melanoma: A Meta-analysis

, 2020
Hiroshi Yokomichi, Takashi Inozume, Makoto Wada, Jun Asai, Hiroshi Igaki, Kenjiro Namikawa, Ayato Hayashi, Satoshi Fukushima, Taku Fujimura, Hiroshi Koga, Yasuhiro Nakamura, M. Mochizuki, Zentaro Yamagata   +12 more
openalex   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

International real-world study of combination immunotherapy sequences in metastatic melanoma. [PDF]

J Immunother Cancer
Guardamagna M, Lochrin SE, Smithy JW, Postow M, Gaudy-Marqueste C, Malissen N, Monestier S, Sullivan RJ, Czapla JA, Lawless AR, Pires da Silva I, Long GV, Menzies AM, Dimitriou F, Dummer R, Marchi C, Chaurand A, Dalle S, Ascierto PA, Paone M, Facchini BA, Warrier G, Lipson EJ, Erdmann M, Berking C, Archambaud B, Roy S, Routier E, Boutros C, Jamme P, Belkadi-Sadou D, Simon-Tillaux N, Robert C.   +32 more
europepmc   +1 more source