Results 231 to 240 of about 885,175 (334)

Prognostic factors in metastatic melanoma [PDF]

, 1993
Louise Ryan, Andrew Kramar, Ernest C. Borden   +2 more
openalex   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Immunotherapy to Address Unmet Needs in Oncology; Two Clinical Vignettes of Response in Metastatic Malignant Melanoma and Non-Small Cell Lung Cancer

, 2015
Arafat Tfayli, Mohammad Nami, Atabak Ghotb   +2 more
openalex   +1 more source

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

Advanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu, Yan Gao, Yadong Guo, Junfeng Zhang, Wentao Zhang, Zhuoran Gu, Haotian Chen, Chengqi Jin, Peng Luo, Shiyu Mao, Yajuan Hao, Shuo Shi, Xudong Yao   +12 more
wiley   +1 more source

Combination of SH003 and paclitaxel modulates tumor microenvironment and inhibits metastasis of metastatic melanoma. [PDF]

Med Oncol
Lee SE, Kim MW, Sim YB, Cheon C, Ko SG.
europepmc   +1 more source

Negative immune checkpoint regulation by VISTA: a mechanism of acquired resistance to anti-PD-1 therapy in metastatic melanoma patients

Modern Pathology, 2017
H. Kakavand, L. Jackett, A. Menzies, T. N. Gide, M. Carlino, R. Saw, John F. Thompson, J. Wilmott, G. Long, R. Scolyer   +9 more
semanticscholar   +1 more source

Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation

Advanced Science, EarlyView.
Photoacoustic microscopy (PAM) is a powerful biomedical imaging tool renowned for its non‐invasiveness and high resolution. This review synthesizes recent technological advances and highlights their broad applications from cellular and organ‐level to whole‐animal imaging.
Tingting Wang, Jiali Chen, Liming Nie, Honghui Li   +3 more
wiley   +1 more source

Single-Dose Neoadjuvant Pembrolizumab in Resectable Metastatic Melanoma. [PDF]

Ann Surg Oncol
Shafique N, Farooq MS, Mattfeld V, Vargas GM, Xu X, Schuchter L, Amaravadi R, Mitchell T, Miura JT, Karakousis GC.   +9 more
europepmc   +1 more source

Gomisin A ameliorates metastatic melanoma by inhibiting AMPK and ERK/JNK-mediated cell survival and metastatic phenotypes

, 2019
Yo-Han Han, Jeong-Geon Mun, Hee Dong Jeon, Jin Bong Park, Ji-Ye Kee, Seung‐Heon Hong   +5 more
openalex   +1 more source