Results 41 to 50 of about 284,307 (179)

New Insights into the Role of Sphingolipid Metabolism in Melanoma

Cells, 2020
Cutaneous melanoma is a deadly skin cancer whose aggressiveness is directly linked to its metastatic potency. Despite remarkable breakthroughs in term of treatments with the emergence of targeted therapy and immunotherapy, the prognosis for metastatic ...
Lorry Carrié, Mathieu Virazels, Carine Dufau, Anne Montfort, Thierry Levade, Bruno Ségui, Nathalie Andrieu-Abadie   +6 more
doaj   +1 more source

iTRAQ Quantitative Proteomic Comparison of Metastatic and Non-Metastatic Uveal Melanoma Tumors. [PDF]

PLoS ONE, 2015
Uveal melanoma is the most common malignancy of the adult eye. The overall mortality rate is high because this aggressive cancer often metastasizes before ophthalmic diagnosis.
John W Crabb, Bo Hu, John S Crabb, Pierre Triozzi, Yogen Saunthararajah, Raymond Tubbs, Arun D Singh   +6 more
doaj   +1 more source

Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model. [PDF]

, 2017
An excessive requirement for methionine termed methionine dependence, appears to be a general metabolic defect in cancer. We have previously shown that cancer-cell growth can be selectively arrested by methionine deprivation such as with recombinant ...
Chmielowski, Bartosz, Dry, Sarah M, Eilber, Fritz C, Han, Qinghong, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Li, Shukuan, Li, Yunfeng, Miyake, Kentaro, Murakami, Takashi, Nelson, Scott D, Russell, Tara A, Tan, Yuying, Unno, Michiaki   +15 more
core   +2 more sources

Antibody Therapy Targeting CD47 and CD271 Effectively Suppresses Melanoma Metastasis in Patient-Derived Xenografts

Cell Reports, 2016
The high rate of metastasis and recurrence among melanoma patients indicates the existence of cells within melanoma that have the ability to both initiate metastatic programs and bypass immune recognition.
Michael Ngo, Arum Han, Anita Lakatos, Debashis Sahoo, Stephanie J. Hachey, Kipp Weiskopf, Andrew H. Beck, Irving L. Weissman, Alexander D. Boiko   +8 more
doaj   +1 more source

Can the plasma PD-1 levels predict the presence and efficiency of tumor-infiltrating lymphocytes in patients with metastatic melanoma? [PDF]

, 2019
Background: The immune response in melanoma patients is locally affected by presence of tumor-infiltrating lymphocytes (TILs), generally divided into brisk, nonbrisk, and absent.
Badalamenti G., Bazan V., Fanale D., Fulfaro F., Incorvaia L., Iovanna J. L., Olive D., Rinaldi G., Russo A., Swayden M., Terruso L., Vincenzi B.   +11 more
core   +1 more source

Transcription analysis in the MeLiM swine model identifies RACK1 as a potential marker of malignancy for human melanocytic proliferation

Molecular Cancer, 2008
Background Metastatic melanoma is a severe disease. Few experimental animal models of metastatic melanoma exist. MeLiM minipigs exhibit spontaneous melanoma. Cutaneous and metastatic lesions are histologically similar to human's.
Vincent-Naulleau Silvia, Geffrotin Claudine, Bernex Florence, Bossé Philippe, Julé Sophia, Egidy Giorgia, Horak Vratislav, Sastre-Garau Xavier, Panthier Jean-Jacques   +8 more
doaj   +1 more source

Label-free high-throughput photoacoustic tomography of suspected circulating melanoma tumor cells in patients in vivo [PDF]

, 2020
Significance: Detection and characterization of circulating tumor cells (CTCs), a key determinant of metastasis, are critical for determining risk of disease progression, understanding metastatic pathways, and facilitating early clinical intervention.
Cornelius, Lynn A., Hai, Pengfei, Li, Yang, Qu, Yuan, Shmuylovich, Leonid, Wang, Lihong V., Zhu, Liren   +6 more
core   +1 more source

IGFBP-3 inhibits Wnt signaling in metastatic melanoma cells. [PDF]

, 2016
In previous works, we have shown that insulin-like growth factor-binding protein-3 (IGFBP-3), a tissue and circulating protein able to bind to IGFs, decreases drastically in the blood serum of patients with diffuse metastatic melanoma.
Londei, Paola, Martella, M, Naspi, A, Panasiti, Vincenzo, Polinari, Dorina, Rosa Alba, R, Sancillo, L, Zingariello, M   +7 more
core   +1 more source

The cost-effectiveness of nivolumab monotherapy for the treatment of advanced melanoma patients in England [PDF]

, 2018
Background: Nivolumab was the first programmed death receptor 1 (PD-1) immune checkpoint inhibitor to demonstrate long-term survival benefit in a clinical trial setting for advanced melanoma patients.
Ellis, John, Hertel, Nadine, Johnson, Helen, Lee, Dawn, Meng, Yang, Morais, Edith, Philips, Zoe, Roskell, Neil, Walker, Andrew   +8 more
core   +1 more source

Ocular Melanoma Metastasizing to Intra-Abdominal Lymph Nodes

Case Reports in Surgery, 2013
Background. Visceral metastatic spread of ocular melanoma most commonly occurs via hematogenous route to the liver. Lymphatic spread of ocular melanoma into abdominal lymph nodes has not been reported previously. Case Presentation. A 47-year-old man with
David Aranovich, Karen Meir, Michal M. Lotem, Liat Appelbaum, Hadar Merhav   +4 more
doaj   +1 more source