Results 51 to 60 of about 885,175 (334)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Effects of HMGA2 on migration and proliferation of leptomeningeal metastatic melanoma [PDF]

Zhongguo aizheng zazhi
Background and purpose: Leptomeningeal metastasis is a form of central nervous system metastasis of melanoma. High mobility group A2 (HMGA2) has been proven to play an important role in the occurrence and development of various tumors, but its biological
LI Xiaohui, ZHAO Jiaxu, PENG Haibao, ZHANG Ye, ZENG Rui, CHI Yudan
doaj   +1 more source

Toxicity, Response and Survival in Older Patients with Metastatic Melanoma Treated with Checkpoint Inhibitors [PDF]

, 2021
Nienke A. de Glas, Esther Bastiaannet, Frederiek van den Bos, Simon P. Mooijaart, Astrid A.M. van der Veldt, Karijn P.M. Suijkerbuijk, Maureen J.B. Aarts, Franchette W.P.J. van den Berkmortel, Christian U. Blank, Marye J. Boers‐Sonderen, Alfonsus Johannes Maria van den Eertwegh, Jan‐Willem B. de Groot, John B.A.G. Haanen, Geke A.P. Hospers, Mathilde Jalving, Djura Piersma, Rozemarijn S. van Rijn, Albert J. ten Tije, Gerard Vreugdenhil, Michel W.J.M. Wouters, Johanneke E.A. Portielje, Ellen Kapiteijn   +21 more
openalex   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Metastatic melanoma of the gallbladder [PDF]

Srpski Arhiv za Celokupno Lekarstvo
Introduction. Malignant melanoma is a tumor of the melanocytes and is one of the most aggressive tumors. In most cases, the first symptoms appear in the metastatic phase of the disease. In clinical practice, malignant melanoma very rarely metastasizes to
Ninić Aleksandar, Stankić Dunja, Grubor Nikola, Mitrović-Jovanović Milica, Grubor Nikica   +4 more
doaj   +1 more source

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis

Cell Death and Disease, 2019
The incidence of melanoma is increasing over the years with a still poor prognosis and the lack of a cure able to guarantee an adequate survival of patients.
M. Gagliardi, D. Cotella, C. Santoro, D. Corà, N. Barlev, M. Piacentini, Marco Corazzari   +6 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Construction of competing endogenous RNA interaction networks as prognostic markers in metastatic melanoma [PDF]

, 2021
Zan He, Zijuan Xin, Yongfei Peng, Hua Zhao, Xiangdong Fang   +4 more
openalex   +1 more source

Integrative Analysis of Long Noncoding RNA (lncRNA), microRNA (miRNA) and mRNA Expression and Construction of a Competing Endogenous RNA (ceRNA) Network in Metastatic Melanoma

Medical Science Monitor, 2019
Worldwide, metastatic melanoma of the skin has an aggressive course with high morbidity and mortality. Therefore, an increased understanding of the pathogenesis of metastatic melanoma has gained increasing attention, including the role of epigenetic ...
Li-Xin Wang, C. Wan, Zhengbang Dong, Bai Wang, Hong-Ye Liu, Yang Li   +5 more
semanticscholar   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source