Results 71 to 80 of about 885,175 (334)
Chimeric Antigen Receptor (CAR) T Cell Therapy for Metastatic Melanoma: Challenges and Road Ahead [PDF]
, 2021 Tahereh Soltantoyeh +7 more
openalex +1 more source
Metabolic heterogeneity confers differences in melanoma metastatic potential
Nature, 2019 Metastasis requires cancer cells to undergo metabolic changes that are poorly understood1–3. Here we show that metabolic differences among melanoma cells confer differences in metastatic potential as a result of differences in the function of the MCT1 ...
Alpaslan Tasdogan +16 more
semanticscholar +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Melanoma stem cells promote metastasis via exosomal miR-1268a inactivation of autophagy
Biological Research, 2022 Background Metastatic melanoma has a high mortality rate and poor survival. This is associated with efficient metastatic colonization, but the underlying mechanisms remain elusive.
Xiaoshuang Li +8 more
doaj +1 more source
Frontiers in Immunology, 2018 Mounting an effective immune response against cancer requires the activation of innate and adaptive immune cells. Metastatic melanoma is the most aggressive form of skin cancer. While immunotherapies have shown a remarkable success in melanoma treatment,
C. Figueiredo +11 more
semanticscholar +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Metabolomics of primary cutaneous melanoma and matched adjacent extratumoral microenvironment.
PLoS ONE, 2020 BackgroundMelanoma causes the vast majority of deaths attributable to skin cancer, largely due to its propensity for metastasis. To date, few studies have examined molecular changes between primary cutaneous melanoma and adjacent putatively normal skin ...
Nicholas J Taylor +10 more
doaj +1 more source
A protein deep sequencing evaluation of metastatic melanoma tissues. [PDF]
PLoS ONE, 2015 Malignant melanoma has the highest increase of incidence of malignancies in the western world. In early stages, front line therapy is surgical excision of the primary tumor. Metastatic disease has very limited possibilities for cure.
Charlotte Welinder +17 more
doaj +1 more source
Case of Metastatic Malignant Melanoma Simulating Granuloma Annulare [PDF]
, 2021 Haley D. Heibel +3 more
openalex +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source