Results 101 to 110 of about 6,340,743 (257)

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

Metastatic renal cell carcinoma presenting as a circumscribed orbital mass

, 2008
Metastatic renal cell carcinoma presenting as a circumscribed orbital massMudiyanselage SY, Prabhakaran VC, Davis GJ and Selva D.http://www.ncbi.nlm.nih.gov/pubmed ...
D. Selva, V.C. Prabhakaran, G.J. Davis, Prabhakaran, V., Davis, G., Selva-Nayagam, D., S.Y. Mudiyanselage, Mudiyanselage, S.   +7 more
core   +1 more source

Histone Lactylation Drives WNK1 Expression to Promote Esophageal Squamous Cell Carcinoma Progression Through Histone H3 Ser10 Phosphorylation

Advanced Science, EarlyView.
In brief. Yan et al. demonstrated that the excess lactate produced by the enhanced glycolysis pathway in esophageal cancer can lactylate H3K23, H3K23la can be enriched in the WNK1 promoter region to promote WNK1 expression, thereby increasing the phosphorylation of the p‐H3 Ser10 site, and p‐H3S10 can be enriched in the AKT1 promoter region to promote ...
Mingyang Yan, Shaobo Fang, Yanming Song, Lei Zhang, Kexin Zhao, Zhenwei Wang, Yang Shao, Meng Liu, Xinyang Jia, Qinxin Guo, Mee‐Hyun Lee, Guoguo Jin, Zigang Dong   +12 more
wiley   +1 more source

A Case Report of Renal Cell Carcinoma Producing Alpha-Fetoprotein [PDF]

, 1992
We report a rare autopsy case of alpha-fetoprotein producing renal cell carcinoma with multiple metastases to liver, gallbladder, mesenterium, and paraaortic lymphnodes. A 58-year-old male patient was diagnosed as having carcinoma of the right kidney. On
Kiyuna, Masaya, Toda, Takayoshi, Shimajiri, Shouhei, Sasi, Ai Muktafi, Tamamoto, Tooru, Shingaki, Yoshisada, Hayakawa, Masamichi   +6 more
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pH‐Responsive Nanoplatform‐Mediated Lipid Hijacking and Metabolic Collapse for Synergistic Starvation‐Immunotherapy

Advanced Science, EarlyView.
A pH‐responsive ZIF‐8/2‐DG@Cu‐TA nanoplatform orchestrates multifaceted metabolic disruption for synergistic starvation‐immunotherapy. Acid‐triggered 2‐DG release blocks glycolysis, while Zn2+ overload induces mitochondrial dysfunction. Concurrently, Cx43‐mediated gap junctions redirect lipid droplets from tumor cells to cancer‐associated fibroblasts ...
Xianlong Zong, Haochen Yao, Danyang Shen, Furu Gong, Zixuan Wang, Haoyang Qin, Yang Yang, Ruirui Qiao, Yongjuan Li, Rui Li   +9 more
wiley   +1 more source

CircFAM65A/CANX Condensates Sequester FAM134B to Inhibit ER‐phagy and Suppress Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
The novel circRNA circFAM65A suppresses HCC progression. Mechanistically, circFAM65A drives CANX phase separation, which recruits FAM134B into condensates and blocks its interaction with LC3, thereby inhibiting ER‐phagy and HCC progression. Importantly, targeted circFAM65A delivery represents a potential therapeutic strategy for HCC.
Wenxiu Ru, Lunbiao Gan, Yu Lu, Yujing Guo, Qian Huang, Sha Yin, Fengze Nie, Sijia Di, Jiaqi Ning, Siyu Yao, Huanhuan Wan, Le Liu, Zehua Liu, Fa Yang, Weijun Qin, Weihong Wen   +15 more
wiley   +1 more source

Renal Cell Carcinoma Metastasis with Nasal Cavity [PDF]

, 2019
Renal hücreli karsinom, erişkin neoplazilerinin %3’ünü oluşturan agresif bir tümördür. En sık metastaz yaptığı yerler akciğer, adrenal, barsak, beyin ve intraabdominal organlardır.
Sevil KARABAĞ, Öznur, Meltem, Ersözlü, Tolga, Tolga ERSÖZLÜ, Karabağ, Sevil, Arslan, Ayşegül, Meltem ÖZNUR, Ayşegül ARSLAN   +7 more
core  

Differentially expressed miRNAs in metastatic clear cell renal cell carcinoma compared to localized tumor (n = 28).

, 2012
Differentially expressed miRNAs in metastatic clear cell renal cell carcinoma compared to localized tumor (n = 28).
Huiqing Wu (163857), Lihong Weng (163790), Bing Mu (163814), Sharon P. Wilczynski (163833), Hanlin Gao (163838), Sumanta K. Pal (163800), Jeffrey J. Wu (163823), Susan H. Onami (163818), Chao Guo (163795), Nora H. Ruel (163829), Lawrence M. Weiss (163853), Xiwei Wu (136542), Yuping Li (157863), Xuejun Li (133209), Robert A. Figlin (163848), Jennifer M. Jin (163803), Rebecca A. Nelson (163810), Maricela Covarrubias (163843)   +17 more
core   +1 more source

Nanocatalytic Immunotherapy Targeting Tumor‐Resident Intracellular Bacteria for Triple‐Negative Breast Cancer Treatment and Metastasis Suppression

Advanced Science, EarlyView.
Bacteria residing within tumor cells contribute to breast cancer progression, but few therapies target their elimination. FeSe2 nanosheets coated with cancer cell membranes accumulate in tumors and generate reactive oxygen species under ultrasound, killing tumor cells and their harbored bacteria at the same time.
Xiaojing Leng, Tao Jiang, Zhao Guo, Zhimin Zhang, Yihan Chen, Pan Li, Min Ge, Han Lin, Liang Zhang   +8 more
wiley   +1 more source

Case report: Metastatic Renal Cell Carcinoma of the tongue

, 2011
A rare presentation of metastatic renal cell carcinoma of the tongue provides the basis for a discussion of the use of novel therapies, which have significantly improved the outlook for patients with renal cell carcinoma.A rare presentation of metastatic
Herbert, C, Pring, M, Cornes, P, Beresford, M   +3 more
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