Results 81 to 90 of about 1,138,740 (267)

Air Pollution Quinones Impair Intestinal Barrier Integrity and Endoplasmic Reticulum in Differentiated Caco‐2 Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati, Giulia Trinchera, Alice Casoni, Alessandra Pecorelli, Mascia Benedusi, Maria Chiara Pietrogrande, Giuseppe Valacchi   +6 more
wiley   +1 more source

High‐Content Screening Comparison of 1R6F Cigarette Smoke Extract and Selected Heated Tobacco and Electronic Vapour Product Aerosol Extracts in Endothelial and Bronchial Epithelial Cell Models

Journal of Applied Toxicology, EarlyView.
ABSTRACT Cigarettes induce oxidative stress and DNA damage, processes that contribute to cardiovascular and pulmonary disease. High content screening (HCS) is an increasingly valuable tool for comparative toxicology because it enables simultaneous quantification of multiple mechanistic endpoints at single‐cell resolution. In this study, HCS was used to
Edgar Trelles Sticken, Konstantinos Papikinos, Fiona Chapman, Roman Wieczorek, Sarah Jean Pour, Torge Evenburg, Sandra Otte, Tiandan Wu, Liam Simms, Matthew Stevenson   +9 more
wiley   +1 more source

Easyhaler®: an overview of an inhaler device for day-to-day use in patients with asthma and chronic obstructive pulmonary disease

Drugs in Context, 2019
Inhalation therapy is likely to continue to dominate asthma and chronic obstructive pulmonary disease (COPD) treatment. The pressurised metered-dose inhaler (pMDI) accounts for most of the global inhaler market, but this kind of device is difficult to ...
Federico Lavorini
doaj   +1 more source

Chronic, Environmentally Relevant PM2.5 Exposure Exacerbates Metabolic Dysfunction‐Associated Steatotic Liver Disease and Early‐Stage Renal Dysfunction in a Rodent Model

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT While epidemiological studies link fine particulate matter (PM2.5) exposure to metabolic dysfunction‐associated steatotic liver disease (MASLD) and renal dysfunction, a translational gap exists, as most animal models utilize acute, high‐dose exposures that poorly reflect chronic, moderate‐level human scenarios.
Yi‐Siao Chen, Hugo You‐Hsien Lin, Chien‐Tzu Lin, Si‐Hua Huang, Ming‐Lun Yeh, Ming‐Lung Yu, Jin‐Ching Lee, Yao‐Chi Chung, Wei‐Ming Li, Ching‐Chia Li, Shiu‐Feng Huang, Chia‐Hung Yen   +11 more
wiley   +1 more source

Assessment of Paediatric resident doctors’ knowledge of metered dose inhaler (MDI) device technique and use [PDF]

, 2017
Background: Inhalational therapy is a major component of asthma management, with efficacy dependent on the patient’s inhalation technique. Proper patient education determines technique mastery and inhalation outcomes.
Ngonadi, S, Ndukwu, CI, Elo-Ilo, JC, Ugwu, N, Ayuk, A, Mbachu, C   +5 more
core   +1 more source

Paraben Exposure in the General Taiwanese Population: Reference Values, Personal Care Products, and Cumulative Risk Assessment

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Parabens (parahydroxybenzoates), which are frequently used as preservatives in pharmaceuticals, foodstuffs, and personal care products, have recently attracted considerable attention due to their adverse health effects and endocrine‐disrupting properties.
Jung‐Wei Chang, Yen‐Hsuan Huang, Hsin‐Chang Chen, Vinoth Kumar Ponnusamy, Wan‐Ting Chang, Po‐Chin Huang   +5 more
wiley   +1 more source

Reference Equations for Peak Nasal Inspiratory and Expiratory Flow: A Cross‐Sectional Study

The Laryngoscope, EarlyView.
This study developed reference equations for peak nasal inspiratory flow (PNIF) and peak nasal expiratory flow (PNEF) in clinically healthy adults using sex, height, and weight. PNIF demonstrated lower residual variability and more stable model performance than PNEF, supporting its potential as a complementary tool for individualized interpretation of ...
Gardênia Maria Martins de Oliveira, Gabriel Zorello Laporta, Joao Paulo Duarte Sabiá, Joao Marcos Ferreira, Edigê Felipe de Sousa Santos, Rodrigo Daminello Raimundo   +5 more
wiley   +1 more source

Factors Affecting Patients’ Compliance to Metered-Dose Inhaler Drugs in Two Asthma Clinics in Tehran, Iran

Iranian Journal of Allergy, Asthma and Immunology, 2006
Asthma affects an estimated 300 million people worldwide. Poor compliance with the prescribed medication leads to increased mortality and morbidity. Various determinants of compliance have been described.
Sanaz Tavasoli, Hassan Heidarnazhad, Anooshiravan Kazemnejad   +2 more
doaj  

Combination formoterol and budesonide as maintenance and reliever therapy versus combination inhaler maintenance for chronic asthma in adults and children. [PDF]

, 2013
BACKGROUND: Asthma is characterised by chronic inflammation of the airways and recurrent exacerbations with wheezing, chest tightness and cough. Treatment with inhaled steroids and bronchodilators often results in good control of symptoms, prevention of ...
Mindus, SM, Ferrara, G, Ferrara, G,, Kew, KM, Karner, C   +4 more
core   +1 more source

Breathe, Eat, Talk: Three Essential Ingredients to Quality‐of‐Life Outcomes in Movement Disorders

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Breathing, eating, and talking (BET) impairments are common yet frequently underrecognized features of movement disorders. Deficits in respiration, swallowing, voice, and speech may emerge early in the course of a disease, adversely affecting safety, participation, and quality of life.
John Dean, Lena C. O’Flynn, Michelle Ciucci, Cynthia Fox, Jessica E. Huber, Supraja Anand, Maira Rozenfeld Olchik, Jibrin S. Usman, Adam P. Vogel, Bettina Aguiar, Diana Khasanova, Dharshini Manoharan, Lorraine Ramig, Angela Roberts, Federico Rodriguez‐Porcel, Kristina Simonyan, Julie M. Barkmeier‐Kraemer   +16 more
wiley   +1 more source