Results 91 to 100 of about 6,051 (258)

Decarbonising Respiratory Care: The Impact of a Low‐Carbon Salbutamol Pressurised Metered‐Dose Inhalers

Allergy, EarlyView.
Healthcare systems contribute up to 5% of global GHG emissions, with inhalers contributing a proportion of these. The carbon footprint of current salbutamol inhalers (pMDI with HFA‐134a propellant and DPI) and a planned salbutamol pMDI with low‐GWP propellant HFA‐152a was quantified across seven countries.
James King, Ashley Woodcock, Antonio Anzueto, Alexander J. K. Wilkinson, Christer Janson, Richard Henderson, Sourabh Fulmali, Maximilian Plank   +7 more
wiley   +1 more source

Formulation and evaluation of CFC free inhalers for beclomethasone dipropionate

Brazilian Journal of Pharmaceutical Sciences, 2013
Beclomethasone dipropionate CFC free inhalation formulations were developed with a view to treat asthma prophylactically. Dry powder inhalers (DPI) for beclomethasone dipropionate were prepared with different grades of lactose monohydrate.
Gopala Krishna Murthy Talasila, Bala Vishnu Priya Mukkala, Satyanarayana Vattikuri   +2 more
doaj   +1 more source

Patients’ sensory perception and satisfaction with use of metered dose inhalers and dry powder inhalers in moderate persistent asthma

, 2019
Background: Inhalers containing corticosteroid and a long acting β2 agonist (LABA) are widely used in asthma treatment. This study assessed the patient sensory perception and satisfaction of budesonide/formoterol fixed dose combination by pressurized ...
Khanna, Jyoti, Chaudhry, Dhruva, Gupta, Mahesh C.   +2 more
core   +1 more source

In Vitro Performance of Valved Holding Chambers in Paediatric Asthma Controller Therapy

Acta Paediatrica, EarlyView.
ABSTRACT Aim Research on the drug delivery of inhaled corticosteroids and combination medications via valved holding chambers (VHCs) with children's breathing patterns is limited. We aimed to evaluate the in vitro performance of commercially available VHCs without facemasks under preschooler breathing conditions, focusing on total delivered dose and ...
Laura Ojanperä, Lauri Lehtimäki, Péter Csonka   +2 more
wiley   +1 more source

Cystic Fibrosis gene therapy: methods for the optimisation of CFTR gene delivery.

, 2010
Gene therapy potentially holds the key for the treatment and cure of many genetic diseases, including cystic fibrosis. A number of delivery methods have been developed for the integration of a functional gene into the host genome, one of which is the use
Kremer, Karlea Lee
core  

High speed photographic analysis of aerosols produced by metered dose inhalers

, 1988
The design of pressurized metered dose inhalers (MDI) used to assess asthma is variable. We have examined the aerosol spray flumes generated by four commercially available MDI products using high speed video photography. For this purpose a moulded jacket
M Balakrishnan, S K Malik, S R Verma, R Dhand   +3 more
core   +1 more source

Early Intervention With Biologics for Asthma Remission: Promising or Premature?

Respirology, EarlyView.
Santi Nolasco, Jaime Bernaola, Parameswaran Nair   +2 more
wiley   +1 more source

The Agents of Climate Justice in Healthcare

Bioethics, EarlyView.
ABSTRACT This paper addresses the critical issue of decarbonising healthcare systems to help combat climate change. I focus on identifying the ‘agents of justice’ responsible for this transformation. Beginning with the claim that healthcare's greenhouse gas emissions cause injustice, the paper assumes that achieving a net zero healthcare system is ...
Joshua Parker
wiley   +1 more source

Design of Pressurized Metered Dose Inhalers Modeling of Internal Flow and Atomization

, 2010
Pressurized metered-dose inhalers (pMDIs) have been the most effective therapeutic treatment for controlling lung diseases such as asthma and COPD. The flow through a two-orifice system of pMDI is very complex and poorly understood. Previous experimental
Abdul Qaiyum Shaik, Henk Versteeg
core   +1 more source

Neurokinin‐1 receptor activation protects against cardiac fibrosis, inflammation and diastolic dysfunction in type 2 diabetic mice

British Journal of Pharmacology, EarlyView.
Background and Purpose The pathogenesis of type 2 diabetes mellitus (T2DM)‐induced cardiomyopathy involves cardiac fibrosis that leads to diastolic dysfunction. We established that replacement of lost substance P (SP) that occurs in T2DM reduces cardiac fibrosis and decreases inflammation in T2DM mice and non‐human primates.
Alexander Widiapradja, Heather Connery, Brody J. Helmick, Kallie J. Schafner, Vamsi Manchikalapudi, Hannah Horvath, Sophia Gugino, Tamas Kriska, Anja Herrnreiter, Evan DeVallance, William B. Campbell, Scott P. Levick   +11 more
wiley   +1 more source