Results 11 to 20 of about 167,880 (309)

Metformin allergy

Indian Journal of Pharmacology, 2011
Metformin is an important antidiabetic agent that is widely used for diabetic patients. Here, a case of metformin allergy, presenting with skin lesions, is reported.
Wiwanitkit, Viroj
core   +5 more sources

Metformin accelerates zebrafish heart regeneration by inducing autophagy. [PDF]

, 2021
Metformin is one of the most widely used drugs for type 2 diabetes and it also exhibits cardiovascular protective activity. However, the underlying mechanism of its action is not well understood. Here, we used an adult zebrafish model of heart cryoinjury,
Xu, Shisan, Manno, S., Tian, L., Xie, F., Yue, J., Ma, A., Cheng, S., Wong, Kin Fung, Hasan, K., Sun, Lei, Tse, G., Lu, Yingying   +11 more
core   +1 more source

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells [PDF]

, 2014
The anti-diabetic drug metformin regulates T-cell responses to immune activation and is proposed to function by regulating the energy-stress-sensing adenosine-monophosphate-activated protein kinase (AMPK).
Benoit Viollet, David K. Finlay, Doreen A. Cantrell, Finlay David K., Viollet, Benoit, Marc Foretz, Cantrell, Doreen A., Viollet Benoit, FINLAY, DAVID, Marouan Zarrouk, Zarrouk, Marouan, David K Finlay, Doreen A Cantrell, Zarrouk Marouan, Foretz, Marc, Foretz Marc, Cantrell Doreen A., Finlay, David K.   +17 more
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Metformin and Cancer [PDF]

The Review of Diabetic Studies, 2013
Metformin is well-known as an anti-diabetic drug, but it seems to possess anti-cancerous properties as well. Adenosine monophosphate-activated protein kinase (AMPK) is a highly conserved regulator of the cellular response to the presence of low energy in all eukaryotic cells.
Natalia G, Vallianou, Angelos, Evangelopoulos, Christos, Kazazis   +2 more
openaire   +4 more sources

Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose [PDF]

, 2013
Background Diabetes is a risk factor for respiratory infection, and hyperglycaemia is associated with increased glucose in airway surface liquid and risk of Staphylococcus aureus infection.
Garnett, James P, Tregoning, John S, Baines, DL, Baines, Deborah L, Knight, Gwenan M, Naik, S, Lindsay, JA, Tregoning, JS, Naik, Sonam, Garnett, JP, Baker, EH, Lindsay, Jodi A, Gill, S, Baker, Emma H, Gill, Simren, Knight, GM   +15 more
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Preventive Effect of ZnO-Metformin Nanocomposite Against Carbon Tetrachloride-Induced Hepatotoxicity [PDF]

Nanomedicine Research Journal
Objective(s): The protective effect of metformin on liver disorders has been reported . Studies have documented the hepatoprotective benefits of metformin against liver disorders, but due to its low bioavailability and untoward side effects, metformin ...
Fatemeh Adibipour, Mahsa Salehirad, A.Wallace Hayes, Malak Hekmati, Majid Motaghinejad   +4 more
doaj   +1 more source

Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin [PDF]

, 2010
OBJECTIVE The aim of this study was to investigate whether apolipoprotein B100 of LDL suffers increased damage by glycation, oxidation, and nitration in patients with type 2 diabetes, including patients receiving metformin therapy.
Rabbani, Naila, D. Zehnder, A. Ceriello, P. J. Thornalley, N. Rabbani, Zehnder, Daniel, Chittari, Madhu Varma, C. W. Bodmer, Bodmer, Charles W., Ceriello, Antonio, M. V. Chittari, Thornalley, Paul J.   +11 more
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Heritability of variation in glycaemic response to metformin:a genome-wide complex trait analysis [PDF]

, 2014
Background: Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable.
Ahlqvist, Emma,, Deshmukh, Harshal, Pearson, Ewan R., Deshmukh, H, Colhoun, Helen M, Morris, Andrew D., Morris, Andrew D, Groop, Leif,, Colhoun, HM, McCarthy, Mark I, Palmer, Colin N A, Yang, J, Palmer, Colin N.A.; id_orcid, Zuydam, NV, Groop, L, Sham, Pak C, Spencer, Chris C, Donnelly, Lousie, Palmer, Colin N. A., Spencer, Chris C., Zhou, KX, Yang, Jian, Spencer, CC, Lund University., Donnelly, Louise, Li, M, Van Zuydam, Natalie, Palmer, CNA, Zhou, Kaixin, Pearson, Ewan R.; id_orcid, McCarthy, ML, Donnelly, L, Li, Miaoxin, Morris, AD, Groop, Leif, Sham, PC, McCarthy, Mark I., Ahlqvist, E, Groop, Lief, Pearson, Ewan R, Pearson, ER, Colhoun, Helen M., Sham, Pak C., Ahlqvist, Emma   +43 more
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COMPARISON OF BLADDER CANCER CELLS APOPTOSIS INDUCED BY METFORMIN, CISPLATIN, AND COMBINATION OF METFORMIN-CISPLATIN: IN VITRO STUDY

Jurnal Urologi Indonesia, 2020
Objective: To evaluate the effect of metformin, cisplatin, and their combination on apoptosis of bladder cancer cells. Material & Methods: Urothelial cell lines 5637 were cultured until 80% confluence.
Arifai Lumbangaol, Lukman Hakim, Doddy M Soebadi, Tarmono Djojodimedjo   +3 more
doaj   +1 more source

Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities

Clinical and Translational Medicine, 2023
Background The biguanide drug metformin is a safe and widely prescribed drug for type 2 diabetes. Interestingly, hundreds of clinical trials have been set to evaluate the potential role of metformin in the prevention and treatment of cancer including ...
Barbora Salovska, Erli Gao, Sophia Müller‐Dott, Wenxue Li, Carlos Chacon Cordon, Shisheng Wang, Aurelien Dugourd, George Rosenberger, Julio Saez‐Rodriguez, Yansheng Liu   +9 more
doaj   +1 more source