Results 11 to 20 of about 148,910 (315)

Oral and intravenous pharmacokinetics of metformin with and without oral codeine intake in healthy subjects: A cross‐over study

Clinical and Translational Science, 2021
The aim of the study was to investigate if there is a clinically relevant drug interaction between metformin and codeine. Volunteers were randomized to receive on four separate occasions: (A) orally administered metformin (1 g), (B) intravenously ...
Ida Kuhlmann, Amanda Nøddebo Nyrup, Tore Bjerregaard Stage, Mette Marie Hougaard Christensen, Troels Korshøj Bergmann, Per Damkier, Flemming Nielsen, Kurt Højlund, Kim Brøsen   +8 more
doaj   +1 more source

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells [PDF]

, 2014
The anti-diabetic drug metformin regulates T-cell responses to immune activation and is proposed to function by regulating the energy-stress-sensing adenosine-monophosphate-activated protein kinase (AMPK).
Benoit Viollet, David K. Finlay, Doreen A. Cantrell, Finlay David K., Viollet, Benoit, Marc Foretz, Cantrell, Doreen A., Viollet Benoit, FINLAY, DAVID, Marouan Zarrouk, Zarrouk, Marouan, David K Finlay, Doreen A Cantrell, Zarrouk Marouan, Foretz, Marc, Foretz Marc, Cantrell Doreen A., Finlay, David K.   +17 more
core   +1 more source

Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities

Clinical and Translational Medicine, 2023
Background The biguanide drug metformin is a safe and widely prescribed drug for type 2 diabetes. Interestingly, hundreds of clinical trials have been set to evaluate the potential role of metformin in the prevention and treatment of cancer including ...
Barbora Salovska, Erli Gao, Sophia Müller‐Dott, Wenxue Li, Carlos Chacon Cordon, Shisheng Wang, Aurelien Dugourd, George Rosenberger, Julio Saez‐Rodriguez, Yansheng Liu   +9 more
doaj   +1 more source

Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose [PDF]

, 2013
Background Diabetes is a risk factor for respiratory infection, and hyperglycaemia is associated with increased glucose in airway surface liquid and risk of Staphylococcus aureus infection.
Garnett, James P, Tregoning, John S, Baines, DL, Baines, Deborah L, Knight, Gwenan M, Naik, S, Lindsay, JA, Tregoning, JS, Naik, Sonam, Garnett, JP, Baker, EH, Lindsay, Jodi A, Gill, S, Baker, Emma H, Gill, Simren, Knight, GM   +15 more
core   +1 more source

Biochemical and histopathological evaluation of the effect of metformin and metformin nanoparticles against alloxan-induced diabetes in Rats [PDF]

Benha Veterinary Medical Journal, 2022
Nanoparticles drug delivery systems are nanometric carriers that enhance drugs delivery and therapeutic action. The current study aimed to investigate the effect of daily oral administration of metformin and metformin nanoparticles (45 mg/kg b.
Aya Allah Salem
doaj   +1 more source

Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin [PDF]

, 2010
OBJECTIVE The aim of this study was to investigate whether apolipoprotein B100 of LDL suffers increased damage by glycation, oxidation, and nitration in patients with type 2 diabetes, including patients receiving metformin therapy.
Rabbani, Naila, D. Zehnder, A. Ceriello, P. J. Thornalley, N. Rabbani, Zehnder, Daniel, Chittari, Madhu Varma, C. W. Bodmer, Bodmer, Charles W., Ceriello, Antonio, M. V. Chittari, Thornalley, Paul J.   +11 more
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Metformin promotes anticancer activity of NK cells in a p38 MAPK dependent manner

OncoImmunology, 2021
Metformin, a drug prescribed to treat type 2 diabetes, has been reported to possess antitumor activity via immunity activation. However, the influence of metformin on natural killer (NK) cells is not fully understood.
Wenjiao Xia, Xin Qi, Mingfeng Li, Yu Wu, Lulu Sun, Xinglong Fan, Yuan Yuan, Jing Li   +7 more
doaj   +1 more source

Metformin accelerates zebrafish heart regeneration by inducing autophagy. [PDF]

, 2021
Metformin is one of the most widely used drugs for type 2 diabetes and it also exhibits cardiovascular protective activity. However, the underlying mechanism of its action is not well understood. Here, we used an adult zebrafish model of heart cryoinjury,
Xu, Shisan, Manno, S., Tian, L., Xie, F., Yue, J., Ma, A., Cheng, S., Wong, Kin Fung, Hasan, K., Sun, Lei, Tse, G., Lu, Yingying   +11 more
core   +1 more source

Patient-factors associated with metformin steady-state levels in type 2 diabetes mellitus with therapeutic dosage

Journal of Clinical & Translational Endocrinology, 2018
Aims: This prospective study aimed to analyze metformin steady-state concentration in repeated constant dosage and the influencing patient-factors as well as to correlate them with glycemic control.
Vitarani D.A. Ningrum, Zullies Ikawati, Ahmad H. Sadewa, Mohammad R. Ikhsan   +3 more
doaj   +1 more source

COMPARISON OF BLADDER CANCER CELLS APOPTOSIS INDUCED BY METFORMIN, CISPLATIN, AND COMBINATION OF METFORMIN-CISPLATIN: IN VITRO STUDY

Jurnal Urologi Indonesia, 2020
Objective: To evaluate the effect of metformin, cisplatin, and their combination on apoptosis of bladder cancer cells. Material & Methods: Urothelial cell lines 5637 were cultured until 80% confluence.
Arifai Lumbangaol, Lukman Hakim, Doddy M Soebadi, Tarmono Djojodimedjo   +3 more
doaj   +1 more source