Results 41 to 50 of about 223,349 (294)

Metformin Promotes Axonal Regeneration and Functional Recovery in Diabetic Rat Model of Sciatic Nerve Transection Injury

NeuroSci, 2022
In our previous study, metformin was able to promote nerve regeneration after sciatic nerve crushing in rats under diabetic conditions. However, a crush injury also has a strong ability to spontaneously recover.
Junxiong Ma, Jun Liu, Yu Chen, Hailong Yu, Liangbi Xiang   +4 more
doaj   +1 more source

Incidence and Survival of Hepatocellular Carcinoma in Type 2 Diabetes Patients with Cirrhosis Who Were Treated with and without Metformin

Diabetes, Metabolic Syndrome and Obesity, 2021
Thanida Tangjarusritaratorn,1 Watip Tangjittipokin,1,2 Tada Kunavisarut3 1Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 2Siriraj Center of Research Excellence in Diabetes and Obesity, Faculty of ...
Tangjarusritaratorn T, Tangjittipokin W, Kunavisarut T   +2 more
doaj  

Differential and Joint Effects of Metformin and Statins on Overall Survival of Elderly Patients with Pancreatic Adenocarcinoma: A Large Population-Based Study. [PDF]

, 2017
Background: Published evidence indicates that individual use of metformin and statin is associated with reduced cancer mortality. However, their differential and joint effects on pancreatic cancer survival are inconclusive.Methods: We identified a large ...
Demissie, Kitaw, E, Jian-Yu, Graber, Judith M., Lin, Yong, Lu, Shou-En, Lu-Yao, Grace, Petersen, Gloria M., Rotter, David, Tan, Xiang-Lin, Zhang, Lanjing   +9 more
core   +2 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes

Cell Reports, 2016
Summary: The therapeutic mechanism of metformin action remains incompletely understood. Whether metformin inhibits glucagon-stimulated endogenous glucose production (EGP), as in preclinical studies, is unclear in humans.
Adam R. Konopka, Raul Ruiz Esponda, Matthew M. Robinson, Matthew L. Johnson, Rickey E. Carter, Michele Schiavon, Claudio Cobelli, Fredric E. Wondisford, Ian R. Lanza, K. Sreekumaran Nair   +9 more
doaj   +1 more source

Towards Understanding the Structure, Dynamics and Bio-activity of Diabetic Drug Metformin

, 2018
Small molecules are often found to exhibit extraordinarily diverse biological activities. Metformin is one of them. It is widely used as anti-diabetic drug for type-two diabetes.
Bagchi, Biman, Bhattacharyya, Aninda J, Mondal, Sayantan, Mukherjee, Saumyak, Samajdar, Rudra N   +4 more
core   +1 more source

Does Metformin combined with Clomiphene Citrate improve fertility related outcomes in Clomiphene resistant women with PCOS : a systematic review [PDF]

, 2014
Peer reviewedPublisher ...
Colleran, Rebecca, Gemmel, Ailsa, Gill, Sabraj, O’Brian, Helen, Poobalan, Amudha, Zanuri, Nurhazwani Bt   +5 more
core   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

Clinical Epigenetics, 2017
Background Given that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance.
Sonia García-Calzón, Alexander Perfilyev, Ville Männistö, Vanessa D. de Mello, Emma Nilsson, Jussi Pihlajamäki, Charlotte Ling   +6 more
doaj   +1 more source

Intracerebroventricular Injection of Metformin Induces Anorexia in Rats [PDF]

Diabetes & Metabolism Journal, 2012
BackgroundMetformin, an oral biguanide insulin-sensitizing agent, is well known to decrease appetite. Although there is evidence that metformin could affect the brain directly, the exact mechanism is not yet known.MethodsTo evaluate whether metformin ...
Chang Koo Lee, Yoon Jung Choi, So Young Park, Jong Yeon Kim, Kyu Chang Won, Yong Woon Kim   +5 more
doaj   +1 more source