Results 61 to 70 of about 148,910 (315)
Metformin-Induced Apoptosis Is Mediated Through Mitochondrial VDAC1
PharmaceuticalsBackground: Besides diabetes mellitus, metformin has been identified as a potential therapeutic agent for treating various other conditions that include various cancers, cardiovascular diseases, neurodegenerative diseases, and aging. In cancer, metformin
Anna Shteinfer-Kuzmine +6 more
doaj +1 more source
Biomolecular Mode of Action of Metformin in Relation to Its Copper Binding Properties [PDF]
, 2014 Metformin (Metf), the most commonly used type 2 diabetes drug, is known to affect the cellular housekeeping of copper. Recently, we discovered that the structurally closely related propanediimidamide (PDI) shows a cellular behavior different from that of
Paterson, Martin J; id_orcid +5 more
core +1 more source
Advanced Science, EarlyView.Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim +2 more
wiley +1 more source
Hepatology, EarlyView., 2022 NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger +7 more
wiley +1 more source
Metformin alleviates breast cancer through targeting high‐mobility group AT‐hook 2
Thoracic Cancer, 2020 Background As a classic oral drug used in diabetic patients, metformin has exhibited an anticancer role in many types of cancers in recent years. Here, we aimed to investigate the role of metformin in the growth of breast cancer and its novel targets ...
Yang Li, Dan Wang, Hui Ren, Wei Feng
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2022 Background Metformin slows tumor growth and progression in vitro, and in combination with chemoradiotherapy, resulted in high overall survival in patients with head and neck cancer squamous cell carcinoma (HNSCC) in our phase 1 clinical trial ...
Maria A Lehn +14 more
doaj +1 more source
, 2019 Background: Metformin-associated lactic acidosis (MALA) and metformin-induced lactic acidosis (MILA) remain controversial entities. Metformin toxic effect depends on accumulation to lead to lactic acidosis (LA), particularly during an episode of acute ...
Pascal Reboul (11557) +11 more
core +1 more source
Advanced Science, EarlyView.Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung +39 more
wiley +1 more source
‘Massive’ metformin overdose [PDF]
British Journal of Clinical Pharmacology, 2018 Massive metformin overdose can cause metabolic acidosis with hyperlactatemia. A 55‐year‐old woman presented 5 h after multidrug overdose, including 132 g extended‐release metformin. Continuous venovenous haemodiafiltration (CVVHDF) and noradrenaline were commenced due to metabolic acidosis (pH 7.0, lactate 17 mmol l–1) and shock. Despite 3 h of CVVHDF,
Angela L. Chiew +7 more
openaire +5 more sources
Metformin and Micronutrient Status in Type 2 Diabetes: Does Polypharmacy Involving Acid-Suppressing Medications Affect Vitamin B12 Levels? [PDF]
, 2020 Metformin is the first-choice drug in uncomplicated type 2 diabetes (T2DM) and is effective in improving glycaemic control. It is the most widely prescribed oral antidiabetic medicine and has a good safety profile.
Wakeman, Michael, Archer, David
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