Results 81 to 90 of about 118,212 (266)

Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE‐Mediated Renal Drug‐Drug Interactions in Healthy Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Regulatory agencies request the assessment of the potential of new drugs to cause transporter‐mediated drug‐drug interactions (DDI). This assessment can be improved by integrating endogenous biomarkers during drug development. Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin ...
Jana Picurová, Fabian Müller, Daniel Auge, Jörg König, Martin F. Fromm, Arne Gessner   +5 more
wiley   +1 more source

Metformin exhibited anticancer activity by lowering cellular cholesterol content in breast cancer cells.

PLoS ONE, 2019
Metformin, a widely prescribed anti-diabetic drug, shows anticancer activity in various cancer types. Few studies documented that there was a decreased level of LDL and total cholesterol in blood serum of metformin users. Based on these views, this study
Ankit Sharma, Shreetama Bandyopadhayaya, Kaushik Chowdhury, Tanu Sharma, Rekha Maheshwari, Amlan Das, Gopal Chakrabarti, Vipin Kumar, Chandi C Mandal   +8 more
doaj   +1 more source

Buried Interface Engineering via a Bifunctional Guanidino‐Carboxyl Molecular Bridge for Enhanced Performance and Stability in Perovskite Solar Cells

EcoEnergy, EarlyView.
A bifunctional molecular bridge using 4‐guanidinobutanoic acid (GCC) is constructed to comprehensively tailor the buried interface of PSCs. By passivating oxygen vacancies, optimizing energy‐level matching, and regulating perovskite crystallization, this strategy simultaneously boosts the power conversion efficiency to 25.37% (20.01% for 13.4 cm2) and ...
Ying Liang, Wenjing Zhou, Yongxuan Zhou, Jiahao Cheng, Wenjian Shen, Guijie Liang, Bin Li, Yong Peng, Zaifang Li, Liu Liu, Jun Yao, Yi‐Bing Cheng, Wangnan Li   +12 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Plasma metformin concentration as a determinant of metabolic response in adults with type 1 diabetes: a 1-year prospective observational study

Frontiers in Pharmacology
BackgroundMetformin is commonly used as adjunctive therapy in adults with type 1 diabetes (T1DM), although evidence regarding its long-term metabolic effects remains inconsistent.
Małgorzata Bekier, Aleksandra Uruska, Michał Michalak, Andrzej Czyrski, Maja Miętkiewska-Dolecka, Danuta Szkutnik-Fiedler   +5 more
doaj   +1 more source

Meta‐analysis of sotagliflozin, a dual sodium‐glucose‐cotransporter 1/2 inhibitor, for heart failure in type 2 diabetes

ESC Heart Failure, Volume 12, Issue 2, Page 968-979, April 2025.
Abstract Sodium‐glucose co‐transporters (SGLTs) mediate sodium and glucose transport across cell membranes. SGLT2 inhibitors have a recognized place within heart failure (HF) guidelines. We evaluated the effect of sotagliflozin on HF and cardiovascular outcomes in participants with type 2 diabetes. Scopus, Medline, Embase and Central were searched from
Maria Anna Bantounou, Panagiotis Sardellis, Josip Plascevic, Ribeya Awaes‐Mahmood, Justyna Kaczmarek, Daniel Black Boada, Rosa Thuemmler, Sam Philip   +7 more
wiley   +1 more source

Pre-Treatment with Metformin in Comparison with Post-Treatment Reduces Cerebral Ischemia Reperfusion Induced Injuries in Rats [PDF]

Bulletin of Emergency and Trauma, 2018
Objective: To explore the effects of pre versus post ischemic treatment with metformin after global cerebral ischemia in rats.Methods: Male Wister rats underwent forebrain ischemia by bilateral common carotid artery occlusion for 17 min.
Mojtaba Karimipour, Sara Shojaei Zarghani, Majid Mohajer Milani, Hamid Soraya   +3 more
doaj  

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

The Effect of Metformin on Pregnancy Outcome Among Filipino Women with Polycystic Ovary Syndrome

Journal of the ASEAN Federation of Endocrine Societies, 2014
Objective.To determine the effect of metformin on maternal and neonatal outcome among pregnant Filipino women with polycystic ovary syndrome (PCOS).   Methodology.This is a retrospective cohort study of PCOS women who were on metformin treatment prior
May Uyking-Naranjo, Evan Paulo Consencino, Roberto Mirasol, Joan Tan-Garcia   +3 more
doaj  

Short‐term clinical responses in horses and ponies treated with canagliflozin: A clinical field study

Equine Veterinary Journal, EarlyView.
Abstract Background Treatment with the sodium‐glucose co‐transporter 2 (SGLT2) inhibitor canagliflozin in insulin dysregulated (ID) horses has shown promising results in randomised clinical trials. Larger field studies are needed to further evaluate treatment responses and potential adverse effects under real‐world conditions.
Moa Hällbom, Sanna Truelsen Lindåse, Monika Wartel, Johan Bröjer   +3 more
wiley   +1 more source