Results 101 to 110 of about 148,910 (315)

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Short-Term Metformin Therapy in Clomiphene Citrate Resistant PCOS Patients Improves Fertility Outcome by Regulating Follicular Fluid Redox Balance: A Case-Controlled Study

Diagnostics
Objectives: To determine the effect of short-term metformin administration on follicular fluid (FF) total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and nuclear factor kappa B (NF-kB) in women with clomiphene ...
Mustafa Tas
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Chinese expert consensus statement on metformin in clinical practice

Chinese Medical Journal, 2020
Expert Group of Metformin in Clinical Practice, Li-Shao Guo   +1 more
doaj   +1 more source

OCT1-Mediated Metformin Uptake Regulates Pancreatic Stellate Cell Activity

Cellular Physiology and Biochemistry, 2018
Background/Aims: Metformin treatment is reported to be associated with a lower incidence of and mortality from pancreatic cancer (PC) in type 2 diabetes patients.
Chunhua Wu, Shanhu Qiu, Xiangyun Zhu, Hao Lin, Ling Li   +4 more
doaj   +1 more source

A Case of Venous Tissue Dissection During Transcatheter MitraClip Surgery

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT The MitraClip system has been widely used to treat mitral regurgitation. The complications associated with MitraClip surgery typically include clip detachment and mitral valve injury. However, cases of venous tissue dissection during surgery are relatively rare.
Shumin Ouyang, Yongqiao Zhou, Yongzhao Yao, Guangzhu Liang, Minqi Liao, Suxia Guo   +5 more
wiley   +1 more source

Metformin Inhibits Mouse Islet Insulin Secretion and Alters Intracellular Calcium in a Concentration-Dependent and Duration-Dependent Manner near the Circulating Range

Journal of Diabetes Research, 2018
Metformin is considered the first-line treatment for type 2 diabetes. While metformin primarily increases insulin sensitivity, evidence also suggests that metformin affects the activity of insulin-secreting pancreatic islets.
Lindor Gelin, Jiewen Li, Kathryn L. Corbin, Ishrat Jahan, Craig S. Nunemaker   +4 more
doaj   +1 more source

Effect of Metformin Use on Survival in Resectable Pancreatic Cancer: A Single-Institution Experience and Review of the Literature.

PLoS ONE, 2016
Observational studies have demonstrated that metformin use in diabetic patients is associated with reduced cancer incidence and mortality. Here, we aimed to determine whether metformin use was associated with improved survival in patients with resected ...
Chenwi M Ambe, Amit Mahipal, Jimmy Fulp, Lu Chen, Mokenge P Malafa   +4 more
doaj   +1 more source

Mitigating ibrutinib‐induced ventricular arrhythmia and cardiac dysfunction with metformin [PDF]

BackgroundIbrutinib is a first‐line drug that targets Bruton's tyrosine kinase for the treatment of B cell cancer. However, cardiotoxicity induced by ibrutinib is a major side effect that limits its clinical use.
Yuan, Meng, Liu, Tong, Zhang, Qingling, Zhou, Zandong, Liu, Xing, Tse, Gary, Zhang, Yue, Zhao, Zhiqiang, Gao, P., Li, Guangping, Liu, Daiqi, Yuan, Ming, Li, Pengsha, Bao, Qiankun   +13 more
core   +1 more source

A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation

Clinical Pharmacology &Therapeutics, EarlyView.
The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix, Sam Mostafa, Amin Rostami‐Hodjegan, Thomas M. Polasek, Carl M. J. Kirkpatrick   +4 more
wiley   +1 more source