Results 111 to 120 of about 148,910 (315)
PLoS ONE, 2012 Metformin inhibits ATP production in mitochondria and this may be involved in the anti-hyperglycemic effects of the drug. Sirtuin 3 (SIRT3) is a mitochondrial protein deacetylase that regulates the function of the electron transport chain and maintains ...
Marcin Buler +3 more
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The Role and Mechanism of Metformin in Inflammatory Diseases
, 2023 Huan Lin,1 Haiyong Ao,2 Guanghua Guo,1 Mingzhuo Liu1 1Medical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China; 2Jiangxi Key Laboratory of Nanobiomaterials & School of ...
Liu M, Guo G, Lin H, Ao H
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Clinical Pharmacology &Therapeutics, EarlyView.Coproporphyrin I (CPI) is an established endogenous biomarker for detecting drug–drug interactions (DDIs) involving the hepatic uptake transporter Organic Anion Transporting Polypeptide 1B1 (OATP1B1, gene SLCO1B1). While CPI has been extensively studied in healthy volunteers using controlled pre‐ and post‐OATP1B1‐inhibitor sampling, its applicability ...
Leila Potzel +9 more
wiley +1 more source
Drugs for diabetes: part 1 metformin
, 2010 Metformin is one of the oldest oral treatments to reduce hyperglycaemia in people with diabetes. Gastrointestinal side effects are common, and metformin should be used with caution in patients with renal impairment because of the slight risk of lactic ...
Fisher, Miles +2 more
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Drug Testing and Analysis, EarlyView.The widespread use of metformin in human medicine coupled with the detection of metformin in blood and urine samples collected from racehorses has raised concern about the potential for exposure from contaminated stalls. This study describes blood and urine concentrations in horses following intentional exposure of horses to metformin contaminated ...
Megan E. Jacobs +5 more
wiley +1 more source
Effect of metformin on apoptosis induction in ovarian cancer cells
, 2014 Introduction: Ovarian cancer is one of the most difficult problems in gynecologic oncology and the search for new drugs effective in the treatment of this kind of cancer, especially in cases resistant to current forms of therapy, remains a challenging ...
Anna Krześlak +5 more
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EcoEnergy, EarlyView.A bifunctional molecular bridge using 4‐guanidinobutanoic acid (GCC) is constructed to comprehensively tailor the buried interface of PSCs. By passivating oxygen vacancies, optimizing energy‐level matching, and regulating perovskite crystallization, this strategy simultaneously boosts the power conversion efficiency to 25.37% (20.01% for 13.4 cm2) and ...
Ying Liang +12 more
wiley +1 more source
, 2020 This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject.
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Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
The Effect of Metformin on Pregnancy Outcome Among Filipino Women with Polycystic Ovary Syndrome
Journal of the ASEAN Federation of Endocrine Societies, 2014 Objective.To determine the effect of metformin on maternal and neonatal outcome among pregnant Filipino women with polycystic ovary syndrome (PCOS). Methodology.This is a retrospective cohort study of PCOS women who were on metformin treatment prior
May Uyking-Naranjo +3 more
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