Results 131 to 140 of about 167,880 (309)

Trust, but Verify: Translating Dosing Evidence to Understudied Populations in Low‐ and Middle‐Income Countries

Clinical Pharmacology &Therapeutics, EarlyView.
Drug dosing recommendations derived from healthy volunteers and selected preregistration populations may not translate reliably to physiologically distinct or understudied groups, particularly in low‐ and middle‐income countries. Using a metformin–dolutegravir drug interaction study and colistin pharmacokinetic study from South Africa, we illustrate ...
Roland van Rensburg, Veshni Pillay‐Fuentes Lorente, Eric Decloedt   +2 more
wiley   +1 more source

Effects of Metformin on JNK Signaling Pathway and PD-L1 Expression in Triple Negative Breast Cancer [PDF]

Ruibin Wang,1,* Yanjie Zhao2,* 1Department of Emergency, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Medical Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing ...
Wang R, Zhao Y
core  

Urogenital Infection Risk Associated With SGLT2 Inhibitors Versus DPP‐4 Inhibitors in Type 2 Diabetes and Chronic Kidney Disease: A Nationwide Target Trial Emulation

Clinical Pharmacology &Therapeutics, EarlyView.
Although sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are recommended for patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD), concerns regarding urogenital infections persist. Therefore, we evaluated the risk of urinary tract infection (UTI) and genital tract infection (GTI) after SGLT2i initiation in this population ...
Young‐Mi Ah, Junsung Nam, Jung Wook Youn, Yun Mi Yu, Soyoung Kang   +4 more
wiley   +1 more source

Metformin inhibits melanin synthesis and melanosome transfer through the cAMP pathway

Scientific Reports
Several studies have demonstrated the inhibitory effect of metformin on pigmentation. However, the effect of metformin on melanosome transfer remains unknown.
Xing Liu, Xiaojie Sun, Yunyao Liu, Wenzhu Wang, Hedan Yang, Yiping Ge, Yin Yang, Xu Chen, Tong Lin   +8 more
doaj   +1 more source

Fixed-dose combination of sitagliptin and metformin for the treatment of type 2 diabetes

, 2009
Jonathan K ReynoldsWashington State University, College of Pharmacy, Pullman, WA, USAAbstract: JanumetTM, a fixed dose combination of sitagliptin/metformin HCL manufactured by Merck Pharmaceuticals, has received US Food and Drug Administration approval ...
Jonathan K Reynolds
core  

Cognitive Behavioral Therapy for Binge‐Eating Disorder in Individuals With Type 2 Diabetes: A Pilot Randomized Controlled Trial

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective To evaluate the feasibility of a randomized pilot trial of group‐based cognitive behavioral therapy (CBT) for binge eating disorder (BED) in individuals with type 2 diabetes, and to estimate exploratory clinical outcomes to inform the design of a future efficacy trial. Method Thirty‐four participants with type 2 diabetes and BED were
Pernille Fiil Nybo, Michael Einar Røder, Mia Beck Lichtenstein, René Klinkby Støving, Jakob Linnet   +4 more
wiley   +1 more source

A rare side effect of metformin: Metformin-induced hepatotoxicity

, 2007
Metformin is an oral hypoglycemic agent that is commonly used in the treatment of type 2 diabetes mellitus. While metformin-associated metabolic acidosis is a widely recognized side effect of this drug, metformin-induced hepatotoxicity has been rarely ...
Kiyan, Selahattin, BAYRAM, BAŞAK, YANTURALI, SEDAT, Aksay, Ersin, HOCAOĞLU AKSAY, NİL   +4 more
core   +1 more source

Buried Interface Engineering via a Bifunctional Guanidino‐Carboxyl Molecular Bridge for Enhanced Performance and Stability in Perovskite Solar Cells

EcoEnergy, EarlyView.
A bifunctional molecular bridge using 4‐guanidinobutanoic acid (GCC) is constructed to comprehensively tailor the buried interface of PSCs. By passivating oxygen vacancies, optimizing energy‐level matching, and regulating perovskite crystallization, this strategy simultaneously boosts the power conversion efficiency to 25.37% (20.01% for 13.4 cm2) and ...
Ying Liang, Wenjing Zhou, Yongxuan Zhou, Jiahao Cheng, Wenjian Shen, Guijie Liang, Bin Li, Yong Peng, Zaifang Li, Liu Liu, Jun Yao, Yi‐Bing Cheng, Wangnan Li   +12 more
wiley   +1 more source

Mitigating ibrutinib‐induced ventricular arrhythmia and cardiac dysfunction with metformin [PDF]

BackgroundIbrutinib is a first‐line drug that targets Bruton's tyrosine kinase for the treatment of B cell cancer. However, cardiotoxicity induced by ibrutinib is a major side effect that limits its clinical use.
Yuan, Meng, Liu, Tong, Zhang, Qingling, Zhou, Zandong, Liu, Xing, Tse, Gary, Zhang, Yue, Zhao, Zhiqiang, Gao, P., Li, Guangping, Liu, Daiqi, Yuan, Ming, Li, Pengsha, Bao, Qiankun   +13 more
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source