Results 91 to 100 of about 148,910 (315)

Characterizing metformin response and sensitivity biomarkers in breast cancer

, 2017
The anti-diabetic drug metformin has been shown to exhibit broad in vitro and in vivo anti-neoplastic activity in various cancer types, including breast cancer.
Anthes, Livia Esther
core  

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Mysterious Metformin

The Oncologist, 2009
The article examines the effects of metformin in both diabetes and cancer.
Curtis R, Chong, Bruce A, Chabner
openaire   +2 more sources

Metformin prevents the doxorubicin-induced cardiomyocytes loss

, 2017
Doxorubicin is a strong antineoplastic agent which can affects intensely on cells during the treatment. Metformin were shown to possess cardioprotective effect. This cardiactoxicity can be reduced after we treat these cells with Metformin. The cells were
Pham Le Khanh, Ha
core  

Active surveillance of drug safety in healthcare data: Sequential monitoring of bacterial and serious urinary tract infection risk in sodium‐glucose cotransporter 2 inhibitor users

British Journal of Clinical Pharmacology, EarlyView.
Abstract Introduction Active surveillance of adverse events using healthcare data is emerging as complementary to the monitoring of spontaneous reports and stand‐alone pharmacoepidemiologic studies. The risk of urinary tract infections (UTIs) was listed as a special warning for sodium‐glucose cotransporter‐2 inhibitors (SGLT2is) when marketed in Europe
Haoxin Le, Dilsad Simay Peker, Lukas Frederic Westphal, Nikolai Brun, Christine Erikstrup Hallgreen, Morten Andersen   +5 more
wiley   +1 more source

Impact of metformin, statin, aspirin and insulin on the prognosis of uHCC patients receiving first line Lenvatinib or Atezolizumab plus Bevacizumab

Scientific Reports
Recently, in Hepatocellular carcinoma (HCC) setting, the use of metformin has been associated to a trend toward worse response rate, overall survival and progression free survival in patients who received immunotherapy.
Margherita Rimini, Margarida Montes, Elisabeth Amadeo, Francesco Vitiello, Masatoshi Kudo, Toshifumi Tada, Goki Suda, Shigeo Shimose, Sara Lonardi, Fabian Finkelmeier, Francesca Salani, Lorenzo Antonuzzo, Fabio Marra, Massimo Iavarone, Giuseppe Cabibbo, Francesco Giuseppe Foschi, Marianna Silletta, Rodolfo Sacco, Ilario Giovanni Rapposelli, Mario Scartozzi, Pella Nicoletta, Luca Aldrighetti, Mara Persano, Silvia Camera, Federico Rossari, Silvia Foti, Takashi Kumada, Atsushi Hiraoka, Hideki Iwamoto, Mario Domenico Rizzato, Vera Himmelsbach, Gianluca Masi, Mattia Corradi, Ciro Celsa, Conti Fabio, Giovanni Luca Frassineti, Stefano Cascinu, Andrea Casadei-Gardini, Jose Presa   +38 more
doaj   +1 more source

Therapeutic effects of Metformin

, 2018
This thesis reviews the wide range of therapeutic effects of Metformin, including treating diabetes mellitus type 2 but also for treating PCOS, type 1 diabetes mellitus, cancer, eclampsia and more. as well as it explains its complex mechanism of action,
Fried, Noa
core  

A prospective series of acute rivaroxaban overdose, coagulopathy and bleeding complications (ATOM 11)

British Journal of Clinical Pharmacology, EarlyView.
Aim There is limited research describing rivaroxaban overdose. We aim to describe rivaroxaban overdose, coagulopathy and bleeding complications. Methods This is a prospective series of acute adult (>14 years) rivaroxaban overdose presentations >40 mg enrolled in the Australian Toxicology Monitoring study and presenting to three Australian clinical ...
Katherine Z. Isoardi, Angela L. Chiew, Keith Harris, Geoffrey K. Isbister   +3 more
wiley   +1 more source

A scoping review of quality prescribing indicators, rules and criteria for primary care

British Journal of Clinical Pharmacology, EarlyView.
Medication‐related problems (MRPs) place a substantial burden on the healthcare system, contributing to hospital admissions and significant healthcare costs. Quality prescribing indicators (QPIs), rules and criteria serve to educate prescribers about high risk MRPs and to monitor prescribing behaviours. This study aims to summarize existing indicators,
James Nind, Anna Mackintosh, Emma Maddock, Alana Delaforce, Gregory Peterson, Elizabeth Manias, Johnson George   +6 more
wiley   +1 more source

Comparative effectiveness of combining antidiabetic medications to treat renal impairment in patients with type 2 diabetes mellitus

Scientific Reports
The comparative renoprotective effects of metformin-GLP-1 RA (glucagon-like peptide 1 receptor agonist), metformin-DPP-4i (dipeptidyl peptidase 4 inhibitor) and metformin-oADM (other antidiabetes medication) in patients with DKD (diabetic kidney disease)
Qiu Mo, Terrence J. Adam, Steven G. Johnson, Amir Moheet, David S. Pieczkiewicz   +4 more
doaj   +1 more source