Results 71 to 80 of about 148,910 (315)

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

Steuerung der Rotation eines Guanidiniumkations durch Kation‐π‐Wechselwirkungen

Angewandte Chemie, EarlyView.
Ein Lanthanid‐π‐Container wurde für die Bindung eines Guanidiniumkations in dessen aromatischer Kavität mittels Kation‐π‐Wechselwirkungen verwendet. Röntgenkristallographie und Festkörper‐NMR‐Spektroskopie bei schneller Rotation um den magischen Winkel wurden verwendet, um die zugrundeliegenden Wirt‐Gast‐Interaktionen zu untersuchen.
Hannah Busch, Lennart Günzel, Ettore Bartalucci, Robert Schuster, Christian Zocher, Martin Börner, Chandan K. Das, Florian Taube, Björn Corzilius, Maria Fyta, Matthias Ernst, Berthold Kersting, Thomas Wiegand   +12 more
wiley   +1 more source

Controlling the Guanidinium Cation Rotation by Cation–π Interactions

Angewandte Chemie International Edition, EarlyView.
A lanthanide π‐container has been employed to trap a guanidinium cation inside the aromatic cavity by cation–π interactions. X‐ray crystallography and solid‐state nuclear magnetic resonance (NMR) spectroscopy at fast magic‐angle spinning (MAS) frequencies have been utilized to probe the underlying host–guest interactions.
Hannah Busch, Lennart Günzel, Ettore Bartalucci, Robert Schuster, Christian Zocher, Martin Börner, Chandan K. Das, Florian Taube, Björn Corzilius, Maria Fyta, Matthias Ernst, Berthold Kersting, Thomas Wiegand   +12 more
wiley   +1 more source

Valproic acid sensitizes metformin-resistant human renal cell carcinoma cells by upregulating H3 acetylation and EMT reversal

BMC Cancer, 2018
Background Metformin (Met) is a widely available diabetic drug and shows suppressed effects on renal cell carcinoma (RCC) metabolism and proliferation. Laboratory studies in RCC suggested that metformin has remarkable antitumor activities and seems to be
Muyun Wei, Shaowei Mao, Guoliang Lu, Liang Li, Xiaopeng Lan, Zhongxian Huang, Yougen Chen, Miaoqing Zhao, Yueran Zhao, Qinghua Xia   +9 more
doaj   +1 more source

Long-term metformin adherence in the Diabetes Prevention Program Outcomes Study

BMJ Open Diabetes Research & Care, 2020
Introduction To investigate long-term metformin adherence in the Diabetes Prevention Program Outcomes Study (DPPOS) by examining: (1) predictors of long-term adherence to study metformin and (2) whether metformin adherence was associated with incident ...
Elizabeth Arquin Walker, Jeffrey S Gonzalez, Mark T Tripputi, Margaret J Matulik, Maria G Montez, Sameh Tadros   +5 more
doaj   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonist Use in Obese Patients Is Associated With Decreased Risk of Revision and Retears After Arthroscopic Rotator Cuff Repair

Arthroscopy, EarlyView.
Purpose To evaluate the impact of preoperative glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) use on medical complications, emergency department use, and orthopaedic complications in obese patients undergoing arthroscopic rotator cuff repair. Methods Obese patients (defined by relevant ICD‐10 codes and confirmed by body mass index measurements ...
Argen Omurzakov, Arsen M. Omurzakov, Robert J. Burkhart, James E. Voos, Jacob G. Calcei, John M. Apostolakos   +5 more
wiley   +1 more source

Metformin allergy

Indian Journal of Pharmacology, 2011
Metformin is an important antidiabetic agent that is widely used for diabetic patients. Here, a case of metformin allergy, presenting with skin lesions, is reported.
openaire   +3 more sources

Metformin: Focus on Melanoma [PDF]

Frontiers in Endocrinology, 2018
Metformin is the most common biguanide used in the treatment of diabetes, with 120 million treated patients worldwide. Metformin decreases hyperglycemia without inducing hypoglycemia in diabetic patients and is very well tolerated. The principal effects of metformin are to decrease hepatic gluconeogenesis and increase glucose absorption by skeletal ...
Emilie Jaune, Emilie Jaune, Stéphane Rocchi, Stéphane Rocchi   +3 more
openaire   +5 more sources

In Vitro Evaluation of the Cytotoxicity of Metformin on Human Gingival Fibroblasts

, 2023
ÖZ Amaç: Bu çalışmanın amacı; antiapoptotik, antienflamatuar ve antioksidan etkileri olan, osteoblastik hücre farklılaşması ve mineralizasyon nodülü oluşumunu indükleyen metformin adlı ilacın Primer İnsan Gingival Fibroblast (HGF) hücreleri üzerindeki ...
Bağrıaçık, Emin Ümit, Gündüz Tekin, Necla, Gökay TEKÇAM, Tekçam, Gökay, Emin Ümit BAĞRIAÇIK, Başman, Adil, Adil BAŞMAN, Necla GÜNDÜZ   +7 more
core   +1 more source

Prescribing competence: The pros and cons of different methods for assessment

British Journal of Clinical Pharmacology, EarlyView.
Evaluating a medical graduate’s competence in rational prescribing is challenging. With the aim to guide and inspire teachers, this narrative review explores different methods that can be used to assess prescribing competence. Each method has its own advantages and disadvantages, and thus a mix of different assessment methods is needed throughout the ...
David J. Brinkman, Erik M. Donker, Jelle Tichelaar, on behalf of the CP4T programme   +3 more
wiley   +1 more source