Results 31 to 40 of about 167,880 (309)
Metformin from mother to unborn child – Are there unwarranted effects?
EBioMedicine, 2018 For more than 40 years, metformin has been used before and during pregnancy. However, it is important to note that metformin can cross the placenta and circulate in the developing foetus.
Linh Nguyen +2 more
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Drugs of Today, 2007 Pioglitazone and metformin have both proven safe and efficacious in the treatment of type 2 diabetes. Their combination into a single tablet seems logical. This article reviews the data that are available for this combination. Because the tablets are not currently widely available, the review examines some aspects of the effects of both agents ...
Hill, N, Matthews, DR
openaire +3 more sources
, 2023 Objectives: This study aimed to evaluate lactic acidosis (LA) risk when using metformin combined with histamine H2 receptor inhibitors (H2RI) in patients with renal failure (RF).
Jianbin Li (312148) +5 more
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Metformin Use beyond Diabetes: Reducing Cardiovascular Events in the Healthy Elderly [PDF]
, 2020 As the global ageing population rises, there is increasing interest and demand for research evaluating anti-ageing strategies. One such strategy involves investigating a drug that may have additional mechanisms and pathways of action to combat ageing ...
Reid, Christopher +3 more
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NeuroSci, 2022 In our previous study, metformin was able to promote nerve regeneration after sciatic nerve crushing in rats under diabetic conditions. However, a crush injury also has a strong ability to spontaneously recover.
Junxiong Ma +4 more
doaj +1 more source
Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes
Cell Reports, 2016 Summary: The therapeutic mechanism of metformin action remains incompletely understood. Whether metformin inhibits glucagon-stimulated endogenous glucose production (EGP), as in preclinical studies, is unclear in humans.
Adam R. Konopka +9 more
doaj +1 more source
Diabetes, Metabolic Syndrome and Obesity, 2021 Thanida Tangjarusritaratorn,1 Watip Tangjittipokin,1,2 Tada Kunavisarut3 1Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 2Siriraj Center of Research Excellence in Diabetes and Obesity, Faculty of ...
Tangjarusritaratorn T +2 more
doaj
Clinical Epigenetics, 2017 Background Given that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance.
Sonia García-Calzón +6 more
doaj +1 more source
JAMA, 2019 Metformin is the first-line pharmacologic treatment for type 2 diabetes and the most commonly prescribed drug for this condition worldwide, either alone or in combination with insulin or other glucose-lowering therapies. Metformin is a biguanide, a drug class of herbal origin that has been widely used to treat diabetes since the 1950s.1,2 Two other ...
James, Flory, Kasia, Lipska
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Effects of metformin on human monocytic THP-1 cells - Implications for type 2 diabetes mellitus [PDF]
, 2010 Metformin is an anti-hyperglycaemic agent widely prescribed for type 2 diabetes (T2D). Despite decades of clinical use, its exact pharmacological mechanism(s) is yet to be definitively determined.
Tsuei, An-Chi
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