Results 31 to 40 of about 223,349 (294)
Journal of Pharmacological Sciences, 2021 Introduction: Heart failure is the final pathway for a wide spectrum of myocardial stress, including hypertension and myocardial infarction. However, the potential effects of metformin on cardiac hypertrophy are still unclear.
Yoichi Sunagawa +10 more
doaj +1 more source
Repurposing metformin for cancer treatment: current clinical studies. [PDF]
, 2016 In recent years, several studies have presented evidence suggesting a potential role for metformin in anti-cancer therapy. Preclinical studies have demonstrated several anticancer molecular mechanisms of metformin including mTOR inhibition, cytotoxic ...
Altman, Jessica K +10 more
core +1 more source
The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer. [PDF]
, 2020 The gut barrier separates trillions of microbes from the largest immune system in the body; when compromised, a "leaky" gut barrier fuels systemic inflammation, which hastens the progression of chronic diseases.
Das, Soumita +9 more
core +3 more sources
Combined Treatment with Exendin-4 and Metformin Attenuates Prostate Cancer Growth. [PDF]
PLoS ONE, 2015 Recently, the pleiotropic benefits of incretin-based therapy have been reported. We have previously reported that Exendin-4, a glucagon-like peptide-1 (GLP-1) receptor agonist, attenuates prostate cancer growth.
Yoko Tsutsumi +9 more
doaj +1 more source
Metformin Targets Foxo1 to Control Glucose Homeostasis
Biomolecules, 2021 Metformin is the first-line pharmacotherapy for type 2 diabetes mellitus (T2D). Metformin exerts its glucose-lowering effect primarily through decreasing hepatic glucose production (HGP).
Xiaoqin Guo +13 more
doaj +1 more source
Drugs in R & D, 2005 Metformin extended release [Glumetza, metformin hydrochloride, metformin gastric retention, metformin GR] is a proprietary once-a-day formulation of metformin hydrochloride under development with Depomed for the treatment of diabetes mellitus. In May 2002, Depomed licensed manufacturing and marketing rights for its proprietary formulation of metformin ...
openaire +4 more sources
Metformin from mother to unborn child – Are there unwarranted effects?
EBioMedicine, 2018 For more than 40 years, metformin has been used before and during pregnancy. However, it is important to note that metformin can cross the placenta and circulate in the developing foetus.
Linh Nguyen +2 more
doaj +1 more source
The Oncologist, 2009 The article examines the effects of metformin in both diabetes and cancer.
Curtis R, Chong, Bruce A, Chabner
openaire +2 more sources
Activation of AMP-activated protein kinase by metformin induces protein acetylation in prostate and ovarian cancer cells [PDF]
, 2016 AMP-activated protein kinase (AMPK) is an energy sensor and master regulator of metabolism. AMPK functions as a fuel gauge monitoring systemic and cellular energy status.
Galdieri, Luciano +3 more
core +2 more sources
Editorial:Metformin: Beyond Diabetes [PDF]
, 2019 International ...
Bost +19 more
core +4 more sources