Results 301 to 310 of about 297,887 (387)

Effects of metformin on transcriptomic and metabolomic profiles in breast cancer survivors enrolled in the randomized placebo-controlled MetBreCS trial. [PDF]

Sci Rep
Strømland PP, Bertelsen BE, Viste K, Chatziioannou AC, Bellerba F, Robinot N, Trolat A, Flågeng MH, Scalbert A, Keski-Rahkonen P, Sears DD, Bonanni B, Gandini S, Johansson H, Mellgren G.   +14 more
europepmc   +1 more source

Increased PAI-1 and tPA Antigen Levels Are Reduced with Metformin Therapy in HIV-Infected Patients with Fat Redistribution and Insulin Resistance

, 2001
Colleen Hadigan
openalex   +1 more source

Identification of Senomorphic miRNAs in Embryonic Progenitor and Adult Stem Cell‐Derived Extracellular Vesicles

Aging Cell, EarlyView.
A senomorphic miRNA cocktail (E5), consisting of miR‐181a‐5p, miR‐92a‐3p, miR‐21‐5p, and miR‐186‐5p, was identified from a pool of miRNAs enriched in extracellular vesicles (EVs) derived from multiple functional human stem cell types. E5 reduces senescence and SASP markers both in cell culture and in aged mice.
Tianpeng Zhang, Allancer D. C. Nunes, Jieun Lee, Dana Larocca, Giovanni Camussi, Sai Kiang Lim, Vicky U. Bascones, Luise Angelini, Ryan D. O'Kelly, Xiao Dong, Laura J. Niedernhofer, Paul D. Robbins   +11 more
wiley   +1 more source

Modulation of the Antitumor Response to Metformin, Caffeine, and Sodium Dichloroacetate by the Hypoxic Microenvironment in Lung Cancer Cells. [PDF]

Int J Mol Sci
Garcia-Martin MO, Castillejos-Lopez M, Prado-Garcia H, Romero-Garcia S, Huerta-Cruz JC, Choreño-Parra JA, Gonzalez-Avila G, Colín-Godínez LA, Paz-Gomez D, Carlos-Reyes Á, Ruiz V, Romero Y, Flores-Soto E, Rodríguez-Silverio J, Lara-Lemus R, Velázquez-Cruz R, Salinas-Lara C, Torres-Espíndola LM, Gálvez AA.   +18 more
europepmc   +1 more source

Metformin as a Tool to Target Aging.

Cell Metabolism, 2016
N. Barzilai, J. Crandall, S. Kritchevsky, M. Espeland   +3 more
semanticscholar   +1 more source

Identifying Age‐Modulating Compounds Using a Novel Computational Framework for Evaluating Transcriptional Age

Aging Cell, EarlyView.
RNAge is a transcriptional based computational approach to measure changes in cellular age upon experimental manipulation. In silico screening of a database of transcriptional changes from drug perturbations identified a novel aging agent that was applied to an hPSC model of neurodegenerative disease to trigger a late‐onset phenotype.
Chao Zhang, Nathalie Saurat, Daniela Cornacchia, Sun Young Chung, Trisha Sikder, Adrianne Nemchik, Andrew Minotti, Lorenz Studer, Doron Betel   +8 more
wiley   +1 more source

Long-term effects of metformin on offspring health: A review of current evidence and future directions. [PDF]

Diabetes Obes Metab
Mayadunne T, Saadati S, Asmelash D, Mason T, Vanky E, Teede H, Mousa A.   +6 more
europepmc   +1 more source

SGLT2 Inhibition by Enavogliflozin Significantly Reduces Aβ Pathology and Restores Cognitive Function via Upregulation of Microglial AMPK Signaling in 5XFAD Mouse Model of Alzheimer's Disease

Aging Cell, EarlyView.
SGLT2 inhibition with Enavogliflozin significantly improves cognitive function and reduces Aβ pathology in the 5XFAD mouse model of Alzheimer's disease. Through AMPK activation, Enavogliflozin enhances microglial mitochondrial function and Aβ phagocytosis while reducing neuroinflammation.
Jihui Han, Jaehoon Song, Eun Sun Jung, Ji Won Choi, Hye Young Ji, Inhee Mook‐Jung   +5 more
wiley   +1 more source

Metformin use in women with polycystic ovary syndrome (PCOS): Opportunities, benefits, and clinical challenges. [PDF]

Diabetes Obes Metab
Saadati S, Mason T, Godini R, Vanky E, Teede H, Mousa A.   +5 more
europepmc   +1 more source

PDG12: CLINICAL BENEFITS AND COST-OFFSETS OF COMBINATION THERAPY WITH NATEGLINIDE PLUS METFORMIN VERSUS METFORMIN ALONE IN DIABETES IN THE NETHERLANDS

, 2001
Boom G van den, MA Koopmanschap, J. Jaime, Jens Grueger   +3 more
openalex   +1 more source