Results 311 to 320 of about 302,269 (383)

A geriatrician's approach to managing the complex older adult with obesity

Obesity, EarlyView.
Abstract The prevalence of obesity in older adults is rapidly increasing due to the demographic shift occurring globally. Older adults with obesity face health care challenges due to multimorbidity, functional dependency, and disability. This population often has prior history of struggles through weight‐loss attempts during the middle years of life ...
Shenbagam Dewar
wiley   +1 more source

Vitamin B12 deficiency in long-term metformin use and clinician awareness: a scoping review protocol. [PDF]

BMJ Open
Parsonage I, Wainwright D, Barratt J.
europepmc   +1 more source

Changes in weight and glycemic control following obesity treatment with semaglutide or tirzepatide by discontinuation status

Obesity, EarlyView.
Abstract Objective The objective of this study was to characterize changes in body weight and glycated hemoglobin (in those with prediabetes at baseline) through 12 months by obesity pharmacotherapy discontinuation status. Methods This retrospective cohort study used electronic health record data from a large health system in Ohio and Florida to ...
Hamlet Gasoyan, W. Scott Butsch, Rebecca Schulte, Nicholas J. Casacchia, Phuc Le, Christopher B. Boyer, Marcio L. Griebeler, Bartolome Burguera, Michael B. Rothberg   +8 more
wiley   +1 more source

Neuroprotective Effects of Metformin Through the Modulation of Neuroinflammation and Oxidative Stress. [PDF]

Cells
Reed S, Taka E, Darling-Reed S, Soliman KFA.   +3 more
europepmc   +1 more source

Association of Glucagon‐Like Peptide‐1 Receptor Agonists With Cancer Risk in Older Adults With Type 2 Diabetes

Obesity, EarlyView.
ABSTRACT Objective The real‐world evidence on the association between glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and cancer risk remains limited and mixed. Methods In 2013–2020 national Medicare claims data, we included cancer‐naïve patients with type 2 diabetes (T2D). We identified those who initiated GLP‐1 RA, sodium‐glucose cotransporter 2
Ying Lu, Hao Dai, Huilin Tang, William T. Donahoo, Thomas J. George, Ramon C. Sun, Sizun Jiang, Aik Choon Tan, Yi Guo, Jonathan D. Licht, John M. Allen, Kelvin P. Lee, Jingchuan Guo, Jiang Bian   +13 more
wiley   +1 more source

Age-dependent neuroinflammation response to voluntary wheel running and Metformin treatment in the frontal cortex of ovariectomized female mice. [PDF]

Sci Rep
Grabowska K, Grabowski M, Morys J, Olakowska E, Małecki A, Barski JJ, Nowacka-Chmielewska M.   +6 more
europepmc   +1 more source

New Approaches to Investigate Novel Agents in Ewing Sarcoma: A Report From the Children's Oncology Group Bone Tumor Committee

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Outcomes for relapsed Ewing sarcoma remain consistently poor. Continued efforts to consider creative new approaches for the treatment of relapsed Ewing sarcoma are needed. The Children's Oncology Group Bone Tumor Committee convened a New Strategies for Ewing Sarcoma Task Force to systematically evaluate agents for inclusion in future Phase II ...
Jessica D. Daley, Susan L. Whiteway, Christine M. Heske, Filemon S. Dela Cruz, Sarah B. Whittle, Sarah Cohen‐Gogo, Anderson B. Collier, Ajay Gupta, Joyce Ohm, Andrew Clark, Alice Soragni, Elizabeth Lawlor, Bhuvana Setty, Patrick J. Grohar, Katie Janeway, Damon R. Reed, Emily K. Slotkin, Kelly M. Bailey   +17 more
wiley   +1 more source

Microneedle-based integrated pharmacokinetic and pharmacodynamic evaluation platform for personalized medicine. [PDF]

Nat Commun
Yang J, Gong X, Zheng Y, Duan H, Chen S, Wu T, Yi C, Jiang L, Haick H.   +8 more
europepmc   +1 more source

Clinical and genetic characteristics of Cornelia de Lange syndrome in pediatric patients

Pediatric Investigation, EarlyView.
NIPBL variants (78.9%) dominate 19 Chinese pediatric Cornelia de Lange syndrome (CdLS). Universal craniofacial anomalies (94.7%) and developmental delay (84.2%) were observed. NIPBL null variants are associated with severe growth impairment and microcephaly, yet overall clinical severity remains heterogeneous, underscoring genotype‐phenotype complexity
Xiaoqiao Li, Ming Cheng, Min Liu, Wenjing Li, Yuchuan Li, Bingyan Cao, Liya Wei, Yuan Ding, Xi Meng, Lele Li, Chunxiu Gong   +10 more
wiley   +1 more source