Results 321 to 330 of about 297,887 (387)

Biomarkers of Aging–NIA Joint Symposium 2024: New Insights Into Aging Biomarkers

Aging Cell, EarlyView.
Summary of key points raised by the Biomarkers of Aging–NIA Symposium 2024. ABSTRACT The second Biomarkers of Aging Symposium, jointly hosted by the National Institute on Aging (NIA) Intramural Research Program and the Biomarkers of Aging Consortium (BAC) on September 12, 2024, in Baltimore, MD, convened leading researchers, clinicians, and ...
Chiara Herzog, Jesse R. Poganik, Nir Barzilai, Nathan Basisty, Isabel Beerman, Daniel W. Belsky, Rafael de Cabo, Julián Candia, Faraz Faghri, Steve Horvath, Andrea B. Maier, Viviana Perez, Payel Sen, Mahdi Moqri, Vadim N. Gladyshev, Luigi Ferrucci   +15 more
wiley   +1 more source

Efficacy and safety of GLP-1 receptor agonists on weight management and metabolic parameters in PCOS women: a meta-analysis of randomized controlled trials. [PDF]

Sci Rep
Lin S, Deng Y, Huang J, Li M, Sooranna SR, Qin M, Tan B.   +6 more
europepmc   +1 more source

Dietary Selenium Deficiency Accelerates the Onset of Aging‐Related Gut Microbial Changes in Aged Telomere‐Humanized Mice, With Akkermansia muciniphila Being the Most Prominent and Alleviating Selenium Deficiency‐Induced Type 2 Diabetes

Aging Cell, EarlyView.
Gut Akkermansia muciniphila is enriched by dietary selenium deficiency in aged telomere‐humanized mice and counteracts dietary selenium deficiency‐induced type 2 diabetes. ABSTRACT Previous studies have shown that dietary selenium (Se) deficiency in mice reshapes gut microbiota, exacerbates healthspan deterioration (e.g., type 2 diabetes), and ...
Ying‐Chen Huang, Hsin‐Yi Lu, Li Zhang, Alicia Olivier, Tung‐Lung Wu, Chuan‐Yu Hsu, Caleb LeGrand, Huawei Zeng, Samantha Curran, Qingzhou Wang, Ramakrishna Nannapaneni, Xue Zhang, Max Ticó, Marco Mariotti, Ryan T. Y. Wu, Gerald F. Combs Jr, Wen‐Hsing Cheng   +16 more
wiley   +1 more source

Gut microbiota-derived glutathione from metformin treatment alleviates intestinal ferroptosis induced by ischemia/reperfusion. [PDF]

BMC Med
Wang F, Wang X, Wang C, Yan W, Xu J, Song Z, Su M, Zeng J, Han Q, Ruan G, Zhang E, Wang W.   +11 more
europepmc   +1 more source

Rapamycin, Not Metformin, Mirrors Dietary Restriction‐Driven Lifespan Extension in Vertebrates: A Meta‐Analysis

Aging Cell, EarlyView.
The authors provide evidence that, together with Dietary Restriction, Rapamcyin and not Metformin, provides a significant lifespan extension in vertebrates. ABSTRACT Dietary restriction (DR) robustly increases lifespan across taxa. However, in humans, long‐term DR is difficult to maintain, leading to the search for compounds that regulate metabolism ...
Edward R. Ivimey‐Cook, Zahida Sultanova, Alexei A. Maklakov   +2 more
wiley   +1 more source

Combination of Periodontal Ligament Stem Cells and Metformin via Organic Cation Transporters for Periodontal Regeneration in Rats. [PDF]

Biomolecules
Qiao Q, Zhao Z, Sun Y, Wang J, Li X, Zhang L, Yang H, Zhang N, Zhang K, Bai Y.   +9 more
europepmc   +1 more source

Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro‐Inflammatory Phenotype of Senescent Cells

Aging Cell, EarlyView.
As a natural senomorphic agent, PQQ targets the intracellular molecule. HSPA8 of senescent cells, resulting in significantly reduced expression of the SASP. PQQ holds prominent potential to delay chronological aging and ameliorate age‐related conditions by acting as an effective senomorphic agent.
Birong Jiang, Hongwei Zhang, Qixia Xu, Zhirui Jiang, Ruikun He, Qiang Fu, Yu Sun   +6 more
wiley   +1 more source

Therapeutic Efficacy of a 1% Metformin Chip as an Adjunct to Nonsurgical Periodontal Therapy: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. [PDF]

Cureus
Soundarya D, Gunupati S, Biradavolu S, Nagarakanti S, Prudhvi SS, Vanditha D.   +5 more
europepmc   +1 more source

CD38‐Targeting Peptide Vaccine Ameliorates Aging‐Associated Phenotypes in Mice

Aging Cell, EarlyView.
Shangcheng Yu et al. revealed that CD38‐targeting peptide vaccine ameliorated aging‐associated physical and cognitive phenotypes in mice. CD38‐vaccine selectively depletes CD38+ myeloid cells, improves glucose tolerance, and enhances oxygen consumption.
Shangcheng Yu, Zhiqiang Li, Yuxiang Tang, Yuling Chen, Yingying Ma, Kunlin Du, Zhaoyun Zong, Kangze Feng, Yali Wei, Limeng Chen, Haiteng Deng   +10 more
wiley   +1 more source

3D-printed microfibers encapsulating stem cells in scaffold with tri-culture and two-stage metformin release for bone/vasculature/nerve regeneration in rats. [PDF]

Bioact Mater
Zhu M, Li X, Xiao L, Yu K, Li J, Dai Z, Zhang Q, Dai J, Jia Z, Bai Y, Zhang K.   +10 more
europepmc   +1 more source