Results 321 to 330 of about 302,269 (383)

Metformin in Diabetic Retinopathy: Mechanisms, Therapeutic Potential, and Barriers. [PDF]

Cureus
Alasbily H, Ali Fahmi F, Abdulhamid Abdala M, Fouad Asheibi A, Adeil Amhidi A, Abed Elallegy A, H Elamami A.   +6 more
europepmc   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

Predicting Drug Transfer Into Human Milk With the Simcyp Simulator: A Contribution From the ConcePTION Project

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Physiologically‐based pharmacokinetic (PBPK) modeling can support decision‐making on maternal medication use during breastfeeding. This study aimed to enhance lactation PBPK models in two ways. First, the utility of integrating permeability‐ versus perfusion‐limited distribution to human milk was explored using the Simcyp Simulator.
Julia Macente, Nina Nauwelaerts, Justine Marine Badée, Rodolfo Hernandes Bonan, Miao‐Chan Huang, Martje Van Neste, Anne Smits, Karel Allegaert, Hedvig Nordeng, Markus Hovd, Frederico Severino Martins, Pieter Annaert   +11 more
wiley   +1 more source

Combined effects of metformin and coenzyme Q10 on doxorubicin-induced cardiotoxicity in male wistar rats. [PDF]

Sci Rep
Mahdizadeh F, Fazaeli A, Rahimi S, Ojarudi M, Sobhi P, Bahrami M, Rezagholizadeh L.   +6 more
europepmc   +1 more source

Development and Verification of Virtual Population Models for Predicting Drug Pharmacokinetics in Ethnic North American Populations

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Ethnic variabilities can affect the outcome of drug pharmacokinetics (PK) and drug–drug interactions (DDI). This work aimed to develop four North American (NA) sub‐populations: White, African American, Asian American, and Hispanic_Latino suitable for physiologically based pharmacokinetic (PBPK) modeling and simulations.
Udoamaka Ezuruike, Jean Dinh, Eman El‐Khateeb, Alex Blenkinsop, Oliver Hatley, Iain Gardner   +5 more
wiley   +1 more source

Association between metformin use and reduced short- and long-term all-cause mortality in patients undergoing cardiac surgery: a retrospective cohort study. [PDF]

Eur J Med Res
Chen B, Tai Y, Kong Y, Wang C.
europepmc   +1 more source

A Combined Modeling Approach to Predict the Effect of Gastric Emptying Delay on the Pharmacokinetics of Small Molecules

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Dulaglutide, a long‐acting glucagon‐like peptide‐1 (GLP‐1) receptor agonist, is approved for improving glycemic control and reducing cardiovascular risks in patients with type 2 diabetes mellitus (T2DM). This research investigates the effect of dulaglutide on gastric emptying and its impact on the pharmacokinetics (PK) of orally administered ...
Maria M. Posada, Karen B. Schneck, Bridget L. Morse, Luc R. A. Rougee, Lai San Tham, Jessica F. Rehmel, Brian Thompson, Stephen D. Stamatis, Stephen D. Hall, Gemma L. Dickinson   +9 more
wiley   +1 more source

Metformin efficacy and tolerance according to genetic polymorphisms of organic cation transporter 1 in Tunisian patients with type 2 diabetes. [PDF]

Front Endocrinol (Lausanne)
Chaker F, Kallel A, Khessairi N, Yazidi M, Oueslati I, Chatti HA, Feki M, Chihaoui M.   +7 more
europepmc   +1 more source

Developments of Thermosensitive Hydrogel for Maxillofacial Bone Regeneration

Small Science, EarlyView.
Thermosensitive hydrogel with seed cells and growth factors presents a new method for bone regeneration, changing states with temperature and offering fluidity, injectability, and controlled drug release. This article reviews thermosensitive hydrogel's role in angiogenesis, neurogenesis, and osteogenesis in maxillofacial bone regeneration and discusses
Qinrou Zhang, Ying Wu, Jialiang Dai, Zihan Jia, Minjia Zhu, Xinyi Li, Le Xiao, Jingyi Li, Zixiang Dai, Yuxing Bai, Jibin Song, Ke Zhang   +11 more
wiley   +1 more source