Results 121 to 130 of about 6,634 (171)
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Metformin hydrochloride: An antihyperglycemic agent
American Journal of Health-System Pharmacy, 1997The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, drug interactions, and dosage and administration of metformin hydrochloride are reviewed. Metformin is an antihyperglycemic agent; it lowers the blood glucose concentration without causing hypoglycemia.
T B, Klepser, M W, Kelly
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Structure of metformin hydrochloride
Acta Crystallographica Section C Crystal Structure Communications, 1989N,N-Dimethylbiguanide hydrochloride, C 4 H 12 N 5 .Cl, M r =165.6, monoclinic, P2 1 /a, a=7.991(3), b=13.950(5), c=8.020(2)A, β=114.98(3)°, V=810.4(5)A 3 , Z=4, D m =1.35(1), D x =1.357Mgm -3 , MoKα, λ=0.7107A, μ=0.41mm -1 , T=295K, F(000)=352.0, R=0.038 and wR=0.032 for 980 observed reflections with I>3σ(I).
M. Hariharan, S. S. Rajan, R. Srinivasan
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Development of novel mucoadhesive pellets of metformin hydrochloride
Archives of Pharmacal Research, 2009Mucoadhesive polymer-coated pellets containing metformin hydrochloride were prepared by the powder-layering technique using a centrifugal fluidizing (CF)-granulator. Four high-viscosity polymers were applied to make the pellets: 1) hydroxymethylcellulose (HPMC), 2) sodium alginate (Na-Alg), 3) HPMC/Carbopol, and 4) sodium carboxylmethylcellulose (Na ...
Jingshu, Piao +8 more
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Extended-Release Metformin Hydrochloride
Treatments in Endocrinology, 2004In the new oral, once-daily, extended-release (ER), single-composition osmotic tablet formulation of the biguanide metformin hydrochloride (metformin XT), metformin is released at a controlled rate from a central osmotic tablet core through a semipermeable coating.
Antona J, Wagstaff, David P, Figgitt
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Current Analytical Chemistry, 2020
Background: Type 2 diabetes mellitus is an expanding health problem. Binary antidiabetic combinations of Metformin Hydrochloride (MET) with either Saxagliptin Hydrochloride (SAX), or Dapagliflozin (DAP) are widely used. Review of the literature revealed that no single HPTLC method has been reported for the simultaneous determination of MET, SAX, and ...
Afnan E. Abdelrahman +2 more
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Background: Type 2 diabetes mellitus is an expanding health problem. Binary antidiabetic combinations of Metformin Hydrochloride (MET) with either Saxagliptin Hydrochloride (SAX), or Dapagliflozin (DAP) are widely used. Review of the literature revealed that no single HPTLC method has been reported for the simultaneous determination of MET, SAX, and ...
Afnan E. Abdelrahman +2 more
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Pharmacokinetic and pharmacodynamic evaluation of floating microspheres of metformin hydrochloride
Drug Development and Industrial Pharmacy, 2012Metformin hydrochloride (MH), a biguanide antidiabetic, is the drug of choice in obese patients. It is well absorbed from the upper part of gastrointestinal tract and has oral bioavailability of 50% to 60%. The objective of this study was to formulate MH into floating microspheres in order to increase its residence time at the site of absorption and ...
Vinay, Pandit +6 more
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Examination of metformin hydrochloride in a continuous dissolution/HDM system
International Journal of Pharmaceutics, 2008A continuous dissolution/absorption system using a hexadecane membrane (HDM) as the permeation measurement has been examined for three distinct formulations of metformin hydrochloride. This system was used to correlate the absorption rate of metformin through the membrane after release from the dosage form to rate of appearance of metformin in the ...
Kyle A, Fliszar, Natalie, Foster
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Advanced Materials Research, 2011
An environmentally friendlier, safer and saver method is described for the assay of drugs as hydrochloride salts namely metformin hydrochloride and phenylpropanolamine hydrochloride via the determination of their chloride contents. In this method, an aqueous solution of drug was treated with measured excess of silver nitrate in the presence of nitric ...
Theerasak Rojanarata +4 more
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An environmentally friendlier, safer and saver method is described for the assay of drugs as hydrochloride salts namely metformin hydrochloride and phenylpropanolamine hydrochloride via the determination of their chloride contents. In this method, an aqueous solution of drug was treated with measured excess of silver nitrate in the presence of nitric ...
Theerasak Rojanarata +4 more
openaire +1 more source