Results 161 to 170 of about 26,256 (214)
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Methacholine inhalation challenge studies
Journal of Allergy and Clinical Immunology, 1979Methacholine sensitivity has become a valuable and widely used technique for studying the irritability of the airways. Asthmatics are lOOto l,OOO-fold more sensitive than normal subjects to various mediators such as methacholine (P-acetyl methacholine).‘-” This degree of sensitivity has been used to define asthma and also as a genetic marker.l The ...
R G, Townley +5 more
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Development of a Methacholine Challenge Method to Minimize Methacholine Waste
Chest, 2003The standard 2-min tidal breathing methacholine challenge utilizes 3 mL to produce an output of 0.26 mL per 2 min, resulting in a substantial amount of methacholine being discarded.To develop a method with reduced methacholine waste and to compare it to the standard method.Twelve subjects with mild, well-controlled asthma volunteered for this ...
Donald W, Cockcroft +2 more
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Archives of internal medicine, 1984
Methacholine challenge has been proposed as a diagnostic test in situations where clinical asthma is suspected but reversible airway obstruction cannot be demonstrated spirometrically. Methacholine challenge was used in 14 patients with suspected asthma and five normal controls.
L J, Fetters, J I, Matthews
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Methacholine challenge has been proposed as a diagnostic test in situations where clinical asthma is suspected but reversible airway obstruction cannot be demonstrated spirometrically. Methacholine challenge was used in 14 patients with suspected asthma and five normal controls.
L J, Fetters, J I, Matthews
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Dose versus concentration of methacholine
Annals of Allergy, Asthma & Immunology, 1999The methacholine challenge test is a common investigation used to identify airway hyperresponsiveness. There has been recent debate as to whether the airway effect is due to the concentration or the dose of methacholine.To determine whether the airway response during a methacholine challenge test is due to the concentration or the dose of methacholine ...
D E, Drotar, B E, Davis, D W, Cockcroft
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Ketotifen and Methacholine‐Induced Bronchospasm
Allergy, 1986In a double‐blind investigation the aspecific bronchus threshold was estimated by administration of methacholine to 16 young atopic patients with proven airways hyper‐reactivity (PC20 histamine 2 mg/ml. The influence of prolonged oral administration (12 weeks) of ketotifen (2 mg/day) on the bronchus threshold value has been studied.
M K, Tjwa, J, Smeets, F, Maesen
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Methacholine bronchial challenge in children
Journal of Allergy and Clinical Immunology, 1982Methacholine sensitivity was evaluated in 166 young subjects who had normal resting spirometric values but who presented problems suggesting lower airways hyperreactivity. Fifty-eight patients (35%) did not have significant sensitivity. The diagnosis of asthma was excluded in this subgroup. Forty-one patients (25%) had mild methacholine sensitivity, 49
G G, Shapiro +3 more
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JAMA: The Journal of the American Medical Association, 1982
In Reply.— As Dr Polk points out, methacholine challenge has been used as a research tool for many years. However, its use in the clinical laboratory has lagged. We would agree with Dr Polk that methacholine challenge is not indicated in the obstructed patient who responds to an inhaled bronchodilator such as isoproterenol or epinephrine.
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In Reply.— As Dr Polk points out, methacholine challenge has been used as a research tool for many years. However, its use in the clinical laboratory has lagged. We would agree with Dr Polk that methacholine challenge is not indicated in the obstructed patient who responds to an inhaled bronchodilator such as isoproterenol or epinephrine.
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Methacholine PC20 Extrapolation
Chest, 1998R, Jokic, E E, Davis, D W, Cockcroft
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Methacholine Inhalation Challenge
Mayo Clinic Proceedings, 1994P D, Scanlon, K C, Beck
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Approved Methodology for Methacholine Challenge
Allergy and Asthma Proceedings, 1989The challenge procedure detailed in this article should serve as a useful adjunct to routine pulmonary function testing for the diagnosis of asthma as well as a research tool for a wide variety of applications. Now that methacholine has been approved by the Food and Drug Administration and made available to the clinician in an appropriate form for ...
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