Results 41 to 50 of about 12,857 (207)

Challenges in interpreting allergen microarrays in relation to clinical symptoms: a machine learning approach. [PDF]

, 2013
Identifying different patterns of allergens and understanding their predictive ability in relation to asthma and other allergic diseases is crucial for the design of personalized diagnostic tools.Allergen-IgE screening using ImmunoCAP ISAC(®) assay was ...
Altmann, Beeh, Bolstad, Breiman, Burrows, Crapo, Custovic, Fayyad, Friedman, Gent, Huber, Knop, Marinho, Melioli, Millán, Murthy, Patelis, Semic-Jusufagic, Simpson, Simpson, Sordillo, Taylor, Wang   +22 more
core   +1 more source

Testes de broncoprovocação com metacolina e com exercício em bicicleta e corrida livre em crianças com asma intermitente Bronchial provocation tests using methacholine, cycle ergometer exercise and free running in children with intermittent asthma

Jornal de Pediatria, 2005
OBJETIVO: Comparar a responsividade de vias aéreas à metacolina e ao teste de exercício na bicicleta ergométrica e corrida livre em crianças com asma intermitente. MÉTODOS: Estudo randomizado.
Ana C. T. G. Souza, Carlos A. C. Pereira
doaj   +1 more source

Airway resistance at maximum inhalation as a marker of asthma and airway hyperresponsiveness [PDF]

, 2011
Background Asthmatics exhibit reduced airway dilation at maximal inspiration, likely due to structural differences in airway walls and/or functional differences in airway smooth muscle, factors that may also increase airway responsiveness to ...
Nancy T Mendonça, Jennifer Kenyon, Adam S LaPrad, Sohera N Syeda, George T O'Connor, Kenneth R Lutchen   +5 more
core   +2 more sources

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Dyspnoea perception during clinical remission of atopic asthma [PDF]

, 2002
Symptoms of atopic asthma often disappear around puberty. The authors recently demonstrated that this clinical remission is accompanied with ongoing airways inflammation in most subjects.
Hoogsteden, H.C. (Henk), Jongste, J.C. (Johan) de, Overbeek, S.E. (Shelley), Prins, J-B. (Jan-Bas), Toorn, L.M. (Leon) van den   +4 more
core   +3 more sources

Work‐Related Asthma From Exposure to Cardboard and Paper Products

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background We assess the contribution of cardboard dust exposure to the development of work‐related asthma (WRA). Prior studies on paper‐dust‐related breathing problems have focused on exposures in the paper milling and pulp industries. There have been no reports of asthma linked to workplace exposure to cardboard dust.
Mason E. Glanville, Mary Jo Reilly, Kenneth D. Rosenman   +2 more
wiley   +1 more source

Long-term effects of allergen sensitization and exposure in adult asthma: a prospective study. [PDF]

, 2009
BACKGROUND: : We investigated the effects of sensitization and exposure to common domestic allergens on longitudinal changes in lung function and bronchial hyperresponsiveness. METHODS: : Subjects attended 2 visits that were 4 years apart.
Adnan Custovic, Angela Simpson, Antens, Ashley Woodcock, Asokananthan, Barter, Braun-Fahrlander, Chapman, Dijkstra, Fowler, Gehring, Gore, Grol, Juniper, Kharitonov, Lange, Langley, Langley, Luczynska, Masoli, Nicholas J. Truman, Salome, Schou, Simpson, Stephen J. Fowler, Stephen J. Langley, Taylor, Thorne, Vonk, Waser, Yan   +30 more
core   +1 more source

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

Use of a vibrating mesh nebulizer for allergen challenge

Allergy, Asthma & Clinical Immunology, 2019
Background Allergen inhalation tests are a valuable research tool. The allergen dose producing an early asthmatic response (EAR) can be predicted from methacholine responsiveness and allergen skin test endpoint (STE).
Donald W. Cockcroft, Beth E. Davis, Christianne M. Blais, Louis-Philippe Boulet, Marie-Éve Boulay, Hélène Villeneuve, Gail M. Gauvreau, Paul M. O’Byrne, Karen J. Howie, Caitlin D. Obminski   +9 more
doaj   +1 more source

MAIT Cells Suppress IgE‐Mediated Asthma via IFNγ‐Dependent B Cell Regulation

Allergy, EarlyView.
In this study, we demonstrate that MAIT cell antagonism during sensitization and challenge with HDM worsens the development of airway hyperreactivity without effects on type 2 or 17 associated cytokine production or lung inflammation. Rather, MAIT cells appear to regulate HDM‐induced asthma through direct inhibition of IgE production.
Angela M. Cannata, Jaclyn W. McAlees, Julie M. Hargis, Archana Shankar, Shouxiong Huang, Senad Divanovic, Ian P. Lewkowich   +6 more
wiley   +1 more source