Results 81 to 90 of about 12,857 (207)
Advanced Science, Volume 13, Issue 18, 27 March 2026.This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan +10 more
wiley +1 more source
A positive methacholine challenge based on specific airway conductance: A case report
Canadian Journal of Respiratory Therapy, 2016 Methacholine challenge tests only determine airway hyper-responsiveness to a nonspecific agent, and can be associated with relatively low sensitivity and specificity; therefore, they should not be used in isolation to diagnose asthma.
Haynes Jeffrey
doaj
BMJ Open, 2019 Objectives A current diagnosis of asthma cannot be objectively confirmed in many patients with physician-diagnosed asthma. Estimates of resource use in overdiagnosed cases of asthma are necessary to measure the burden of overdiagnosis and to evaluate ...
Mohsen Sadatsafavi +4 more
doaj +1 more source
Acute Exercise Challenge and Airway Dynamics in Youth With Sickle Cell Anemia: A Multicenter Study
American Journal of Hematology, Volume 101, Issue 3, Page 418-426, March 2026.Changes in airway dynamics in children with sickle cell anemia after maximal cardiopulmonary exercise testing and a controlled intensity interval excercise challenge. ABSTRACT Sickle cell anemia (SCA) leads to reduced physical functioning and cardiopulmonary fitness. Prior studies suggest that airway hyperresponsiveness to bronchoprovocation testing is
Robyn T. Cohen +9 more
wiley +1 more source
Sickle cell disease: Wheeze or asthma? [PDF]
, 2015 Sickle cell disease (SCD) is the most common life-limiting genetic disease among African Americans, affecting more than 100,000 people in the United States.
Cohen, Robyn T +2 more
core +2 more sources
ClinicoEconomics and Outcomes Research, 2021 Josep Darbà,1 Meritxell Ascanio,2 Jörgen Syk,3– 5 Kjell Alving4 1Department of Economics, Universitat de Barcelona, Barcelona, Spain; 2BCN Health Economics & Outcomes Research, S.L., Barcelona, Spain; 3Department of Neurobiology ...
Darbà J, Ascanio M, Syk J, Alving K
doaj
Dyspnea and Wheezing after Adenosine Injection in a Patient with Eosinophilic Bronchitis
Case Reports in Medicine, 2009 A 58-year-old nonsmoker female was referred for evaluation of chronic cough of 13 months duration. After an initial work-up, the patient was diagnosed to have chronic cough due to eosinophilic bronchitis.
Rodrigo Cartin-Ceba +2 more
doaj +1 more source
European Clinical Respiratory Journal, 2020 Background Asthma is a common chronic airway disease associated with hyperresponsiveness and airway inflammation. Anti-inflammatory medication especially inhaled corticosteroids are important for control of airway inflammation, decrease of airway ...
Ayfer Topcu +4 more
doaj +1 more source
Microbial ligand costimulation drives neutrophilic steroid-refractory asthma [PDF]
, 2015 Asthma is a heterogeneous disease whose etiology is poorly understood but is likely to involve innate responses to inhaled microbial components that are found in allergens.
Brombacher, Frank +16 more
core +7 more sources
An Improved Model of House Dust Mite Allergic Sensitization [PDF]
, 2016 The existing mouse models for allergic asthma are incapable of reproducing all of the immunogenic and physiological features of allergic asthma as seen in humans. These models can also induce some changes inconsistent with human disease.
Kostin, Susan F.
core +1 more source