The adeno associated viral vectored Dp12S vaccine effective alleviation of asthma symptoms in mice. [PDF]
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The novel AT2 receptor ligand, β-Pro7 Ang III, induces equivalent anti-fibrotic effects to Compound 21 but broader anti-fibrotic effects than pirfenidone in mice with bleomycin-induced pulmonary fibrosis. [PDF]
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Dog allergen-induced asthma in mice: a relevant model of T2<sup>low</sup> severe asthma with airway remodelling. [PDF]
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Uncovering the mechanism of resveratrol in the treatment of asthma: a network pharmacology approach with molecular docking and experimental validation. [PDF]
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Stability of Methacholine Chloride in Bronchial Provocation Test Solutions
American Journal of Health-System Pharmacy, 1981The stability of methacholine chloride (5 mg/ml) in 0.9% sodium chloride solution was measured. A reliable colorimetric assay (530 nm) based on the formation of a hydroxamic acid-iron complex was used. At appropriate time intervals, samples were removed from solutions stored at 4, 20, 37, 60, or 80 degrees C and assayed. The degradation of methacholine
N C, MacDonald +3 more
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Effect of methacholine chloride on rheology and transport of canine tracheal mucus
Journal of Applied Physiology, 1979The effect of methacholine chloride (M) on tracheal mucus was investigated in three conscious tracheostomized dogs. Aerosols of M in concentrations of 2--32 mg/ml were delivered intratracheally for 1 min. Mucus was sampled with a cytology brush at 2 min postchallenge and at irregular intervals thereafter.
M, King, N, Viires
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In 1953, Lobitz and Campbell11described a strikingly abnormal cutaneous response in patients with atopic dermatitis. When acetylcholine and its derivative methacholine (acetyl-β-methylcholine; Mecholyl) were injected intradermally, a delayed blanch of the skin was seen at the site of injection. This was in marked contrast to the erythematous wheal that
L L, CLARK, R R, KIERLAND, G M, ROTH
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Stability of stored methacholine chloride solutions: clinically useful information.
The American review of respiratory disease, 1982Methacholine inhalation challenge (MIC) has been shown to be an extremely useful diagnostic test. Because a decrease in the time and expense involved in the preparation of methacholine chloride solutions might encourage more laboratories to perform MIC, we assessed the stability of several different concentrations of methacholine chloride in solution ...
M R, Pratter +3 more
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Persons with hyperreactive airways differ quantitatively from normal persons in their response to bronchial provocation testing with methacholine chloride (Mch). Methacholine chloride has strong hygroscopic properties that necessitate careful dessication, preparation, and handling if accurate results are to be achieved. The rate of hydration of Mch was
W M, Alberts +2 more
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