Results 1 to 10 of about 3,643,521 (182)

Electrophysiological and ultrastructural events evoked by methacholine and intracellular photolysis of caged compounds in cultured ovine trachea submucosal gland cells [PDF]

Experimental Physiology, 1996
Cultured ovine trachea submucosal gland cells release lysozyme in response to extracellular application of secretagogues, including the muscarinic receptor agonist methacholine (20 microM). Investigation of the ultrastructure has shown that these cells contain electron‐dense cored granules, which differ from the intact tissue, but appear to be released
A, Griffin, T M, Newman, R H, Scott
openaire   +3 more sources

Profibrotic predictive toxicology in the lung [PDF]

Frontiers in Pharmacology
IntroductionFibrosis in the gossamer alveolar capillary membranes of the lung can lead to abnormalities in gas exchange, hypoxemia and death of the individual.
Pooja Singh, Rajesh Sinha, Veena B. Antony   +2 more
doaj   +2 more sources

A novel quinoline with airway relaxant effects and anti-inflammatory properties

Respiratory Research
Background In chronic pulmonary diseases characterized by inflammation and airway obstruction, such as asthma and COPD, there are unmet needs for improved treatment.
Jesper Bergwik, Jielu Liu, Médea Padra, Ravi K. V. Bhongir, Lloyd Tanner, Yujiao Xiang, Mia Lundblad, Arne Egesten, Mikael Adner   +8 more
doaj   +2 more sources

Electronic Nose Breathprints Are Independent of Acute Changes in Airway Caliber in Asthma

Sensors, 2010
Molecular profiling of exhaled volatile organic compounds (VOC) by electronic nose technology provides breathprints that discriminate between patients with different inflammatory airway diseases, such as asthma and COPD.
Jan van der Maten, Marc P. van der Schee, Ariane H. Wagener, Selma B. de Nijs, Erica Dijkers, Peter J. Sterk, Zsofia Lazar, Niki Fens   +7 more
doaj   +2 more sources

Intracellular interactions of umeclidinium and vilanterol in human airway smooth muscle

International Journal of COPD, 2017
Nooreen Shaikh,1,2 Malcolm Johnson,3 David A Hall,4 Kian Fan Chung,1,2 John H Riley,3 Sally Worsley,5 Pankaj K Bhavsar1,2 1Experimental Studies, National Heart and Lung Institute, Imperial College London, 2Biomedical Research Unit, Royal Brompton and ...
Shaikh N, Johnson M, Hall DA, Chung KF, Riley JH, Worsley S, Bhavsar PK   +6 more
doaj   +2 more sources

Variation in CFTR-dependent 'β-sweating' among healthy adults.

PLoS ONE, 2022
The genetic disease cystic fibrosis (CF) results when mutations in the gene for the anion channel CFTR reduce CFTR's activity below a critical level. CFTR activity = N·PO·γ (number of channels x open probability x channel conductance).
Lesje DeRose, Jeeyeon Kim, Miesha Farahmand, Meagan Y Shinbashi, Nam Soo Joo, Jeffrey J Wine   +5 more
doaj   +2 more sources

Deficiency of RAMP1 attenuates antigen-induced airway hyperresponsiveness in mice. [PDF]

PLoS ONE, 2014
Asthma is a chronic inflammatory disease affecting the lung, characterized by breathing difficulty during an attack following exposure to an environmental trigger. Calcitonin gene-related peptide (CGRP) is a neuropeptide that may have a pathological role
Manyu Li, Sarah E Wetzel-Strong, Xiaoyang Hua, Stephen L Tilley, Erin Oswald, Matthew F Krummel, Kathleen M Caron   +6 more
doaj   +1 more source

Biseugenol Exhibited Anti-Inflammatory and Anti-Asthmatic Effects in an Asthma Mouse Model of Mixed-Granulocytic Asthma

Molecules, 2020
In the present work, the anti-inflammatory and antiasthmatic potential of biseugenol, isolated as the main component from n-hexane extract from leaves of Nectandra leucantha and chemically prepared using oxidative coupling from eugenol, was evaluated in ...
Vitor Ponci, Rafael C. Silva, Fernanda Paula R. Santana, Simone S. Grecco, Célia Regina M. Fortunato, Maria A. Oliveira, Wothan Tavares-de-Lima, Clarice R. Olivo, Iolanda de Fátima L. Calvo Tibério, Kaio S. Gomes, Carla M. Prado, João Henrique G. Lago   +11 more
doaj   +1 more source

Airway Hyperresponsiveness, Inflammation, and Pulmonary Emphysema in Rodent Models Designed to Mimic Exposure to Fuel Oil–Derived Volatile Organic Compounds Encountered during an Experimental Oil Spill

Environmental Health Perspectives, 2020
Background: Fuel oil–derived volatile organic compounds (VOCs) inhalation is associated with accidental marine spills. After the Prestige petroleum tanker sank off northern Spain in 2002 and the Deepwater Horizon oil rig catastrophe in 2009, subjects ...
Ó. Amor-Carro, Kathryn White, R. Fraga-Iriso, L. Mariñas-Pardo, L. Núñez-Naveira, B. Lema-Costa, Marta Villarnovo, H. Verea-Hernando, D. Ramos-Barbón   +8 more
semanticscholar   +1 more source

Comparative pharmacodynamic and pharmacokinetic study of MIDD0301 and its (S) enantiomer

Drug development research (Print), 2022
MIDD0301 is being developed as an oral drug to relax airway smooth muscle (ASM) and reduce lung inflammation in asthma. We report a comparative study of MIDD0301 and its S isomer (MIDD0301S), and found that the compounds have equivalent affinity for γ ...
M. S. Rashid Roni, Nicolas M. Zahn, G. Yocum, Daniel A. Webb, Md Yeunus Mian, Michelle J Meyer, Anika S Tylek, J. Cook, C. Emala, D. Stafford, L. Arnold   +10 more
semanticscholar   +1 more source